Dietary polyphenols and their biological significance
Open accessAbstract
Dietary polyphenols represent a wide variety of compounds that occur in fruits,vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They aremostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins andphenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis,anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascularprotection, improvement of the endothelial function, as well as inhibition of angiogenesisand cell proliferation activity. Most of these biological actions have been attributed to theirintrinsic reducing capabilities. They may also offer indirect protection by activatingendogenous defense systems and by modulating cellular signaling processes such asnuclear factor-kappa B (NF-кB) activation, activator protein-1(AP-1) DNA binding,glutathione biosynthesis, phosphoinositide 3 (PI3)-kinase/protein kinase B (Akt) pathway,mitogen-activated protein kinase (MAPK) proteins [extracellular signal-regulated proteinkinase (ERK), c-jun N-terminal kinase (JNK) and P38 ] activation, and the translocationinto the nucleus of nuclear factor erythroid 2 related factor 2 (Nrf2). This paper covers themost recent literature on the subject, and describes the biological mechanisms of action andprotective effects of dietary polyphenols.
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Polyphenols exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties.
“They exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties [190,191,192,193,197].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]
Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects.
“Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects [25,190,193,197,198,199].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]
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Tau protein and tau aggregation inhibitors
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What is the future of Bee-Pollen?
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Biofortification for combating ‘hidden hunger’ for iron
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Pinto Beans (Phaseolus vulgaris L.) as a Functional Food: Implications on Human Health
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Physical and Antibacterial Properties of Edible Films Formulated with Apple Skin Polyphenols
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Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences
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Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?
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Nanoencapsulation of polyphenols for protective effect against colon–rectal cancer
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Procyanidins and inflammation: Molecular targets and health implications
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Phenolic Content and Antioxidant and Antimutagenic Activities in Tomato Peel, Seeds, and Byproducts
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Improving the Polyphenol Content of Tea
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The effects of dietary polyphenols on reproductive health and early development†
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Biological Importance of Cotton By-Products Relative to Chemical Constituents of the Cotton Plant
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Microencapsulation of Natural Food Colourants
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Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome
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- Authors
- Han, X., Shen, T., & Lou, H.
- Affiliations
- Shandong University (CN)
- Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, P. R. China
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2007-09-12
- Volume
- 8
- Issue
- 9
- Pages
- 950-988
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3871896
- OpenAlex
- W2166129369
- Cited by
- 1,081
- References
- 200
- Citations by year
- 2026: 29 · 2025: 44 · 2024: 78 · 2023: 83 · 2022: 81 · 2021: 80 · 2020: 79 · 2019: 78 · 2018: 72 · 2017: 75 · 2016: 60 · 2015: 54 · 2014: 80 · 2013: 52 · 2012: 48
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- dietary polyphenols, flavonoids, catechins, phenolic acids, isoflavones, flavonols, antioxidant activity, anti-inflammatory activity, anticarcinogenic activity, anti-aging, cardioprotection, endothelial function, angiogenesis inhibition, cell proliferation inhibition, NF-κB signaling, MAPK signaling, PI3K/Akt signaling, Nrf2, glutathione synthesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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