Cited by 1,081Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

Dietary polyphenols and their biological significance

Open access
Han, Xiuzhen, Shen, Tao, Lou, Hongxiang·2007·International Journal of Molecular Sciences

Abstract

Dietary polyphenols represent a wide variety of compounds that occur in fruits,vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They aremostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins andphenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis,anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascularprotection, improvement of the endothelial function, as well as inhibition of angiogenesisand cell proliferation activity. Most of these biological actions have been attributed to theirintrinsic reducing capabilities. They may also offer indirect protection by activatingendogenous defense systems and by modulating cellular signaling processes such asnuclear factor-kappa B (NF-кB) activation, activator protein-1(AP-1) DNA binding,glutathione biosynthesis, phosphoinositide 3 (PI3)-kinase/protein kinase B (Akt) pathway,mitogen-activated protein kinase (MAPK) proteins [extracellular signal-regulated proteinkinase (ERK), c-jun N-terminal kinase (JNK) and P38 ] activation, and the translocationinto the nucleus of nuclear factor erythroid 2 related factor 2 (Nrf2). This paper covers themost recent literature on the subject, and describes the biological mechanisms of action andprotective effects of dietary polyphenols.

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  • Polyphenols exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties.

    “They exhibit anti-inflammatory, antibacterial, antifungal, antiviral, antiallergic, anticancer and anticoagulant properties [190,191,192,193,197].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]

  • Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects.

    “Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects [25,190,193,197,198,199].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [190]

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1 of the 200 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. [25]Lotito S.B. Frei B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon? Free Radic. Biol. Med 2006 41 1727 1746 17157175
  2. [163]Kuo P.L. Chiang L.C. Lin C.C. Resveratrol-induced apoptosis is mediated by p53-dependent pathway in HepG2 cells Life Sci 2002 72 23 34 12409142
  3. [170]Meeran S.M. Katiyar S.K. Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, and caspase-3 activation via loss of mitochondrial membrane potential Exp. Dermatol 2007 16 405 415 17437483
  4. [191]Seeram N.P. Lee R. Heber D Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice Clin. Chim. Acta 2004 348 63 68 15369737
  5. [194]Henning S.M. Niu Y. Liu Y. Lee N.H. Hara Y. Thames G.D. Minutti R.R. Carpenter C.L. Wang H. Heber D. Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals J. Nutr. Biochem 2005 16 610 616 16081270

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Authors
Han, X., Shen, T., & Lou, H.
Affiliations
  • Shandong University (CN)
  • Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, P. R. China
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2007-09-12
Volume
8
Issue
9
Pages
950-988
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2166129369
Cited by
1,081
References
200
Citations by year
2026: 29 · 2025: 44 · 2024: 78 · 2023: 83 · 2022: 81 · 2021: 80 · 2020: 79 · 2019: 78 · 2018: 72 · 2017: 75 · 2016: 60 · 2015: 54 · 2014: 80 · 2013: 52 · 2012: 48
FWCI
10.97
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords
dietary polyphenols, flavonoids, catechins, phenolic acids, isoflavones, flavonols, antioxidant activity, anti-inflammatory activity, anticarcinogenic activity, anti-aging, cardioprotection, endothelial function, angiogenesis inhibition, cell proliferation inhibition, NF-κB signaling, MAPK signaling, PI3K/Akt signaling, Nrf2, glutathione synthesis

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