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Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: A review
Open accessAbstract
Significant advancements have been noticed in cancer therapy for decades. Despite this, there are still many critical challenges ahead, including multidrug resistance, drug instability, and side effects. To overcome obstacles of these problems, various types of materials in biomedical research have been explored. Chief among them, the applications of natural compounds have grown rapidly due to their superb biological activities. Natural compounds, especially polyphenolic compounds, play a positive and great role in cancer therapy. Tannic acid (TA), one of the most famous polyphenols, has attracted widespread attention in the field of cancer treatment with unique structural, physicochemical, pharmaceutical, anticancer, antiviral, antioxidant and other strong biological features. This review concentrated on the basic structure along with the important role of TA in tuning oncological signal pathways firstly, and then focused on the use of TA in chemotherapy and preparation of delivery systems including nanoparticles and hydrogels for cancer therapy. Besides, the application of TA/Fe3+ complex coating in photothermal therapy, chemodynamic therapy, combined therapy and theranostics is discussed.
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“Tannic acid (TA), a natural polyphenolic compound, has attracted significant attention in the biomedical field due to its potent antioxidant and anti-inflammatory properties24,25, indicating its potential for application in the treatment of osteoporotic fractures.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [24]
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Metadata
- Authors
- Ghasemian, M., Kazeminava, F., Naseri, A., Mohebzadeh, S., Abbaszadeh, M., Kafil, H. S., & Ahmadian, Z.
- Affiliations
- Lorestan University of Medical Sciences (IR)
- Tabriz University of Medical Sciences (IR)
- University of Mohaghegh Ardabili (IR)
- Corresponding author
- Kafil, Hossein Samadi
- Ahmadian, Zainab
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 166
- Pages
- 115328
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4385847696
- Cited by
- 55
- References
- 213
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 15 · 2023: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Lorestan University of Medical Sciences
- Tabriz University of Medical Sciences
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Chemistry › Organic Chemistry › Tannin, Tannase and Anticancer Activities
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- tannic acid, polyphenols, cancer therapy, anticancer activity, chemotherapy, drug delivery systems, nanoparticles, hydrogels, photothermal therapy, chemodynamic therapy, Fe3+ complexes, theranostics, multidrug resistance
- MeSH terms
- Biocompatible Materials, Humans, Neoplasms, Tannins, Polyphenols
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