The DOI matches its Crossref record; 210 of the 213 references it cites were found in a registry or an index.
Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: A review
Open accessAbstract
Significant advancements have been noticed in cancer therapy for decades. Despite this, there are still many critical challenges ahead, including multidrug resistance, drug instability, and side effects. To overcome obstacles of these problems, various types of materials in biomedical research have been explored. Chief among them, the applications of natural compounds have grown rapidly due to their superb biological activities. Natural compounds, especially polyphenolic compounds, play a positive and great role in cancer therapy. Tannic acid (TA), one of the most famous polyphenols, has attracted widespread attention in the field of cancer treatment with unique structural, physicochemical, pharmaceutical, anticancer, antiviral, antioxidant and other strong biological features. This review concentrated on the basic structure along with the important role of TA in tuning oncological signal pathways firstly, and then focused on the use of TA in chemotherapy and preparation of delivery systems including nanoparticles and hydrogels for cancer therapy. Besides, the application of TA/Fe3+ complex coating in photothermal therapy, chemodynamic therapy, combined therapy and theranostics is discussed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Tannic acid (TA), a natural polyphenolic compound, has attracted significant attention in the biomedical field due to its potent antioxidant and anti-inflammatory properties24,25, indicating its potential for application in the treatment of osteoporotic fractures.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [24]
Citations
Cites
Photodynamic therapy for cancer
Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1071 · Cited by 6,850
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Cancer drug resistance: an evolving paradigm
Holohan, C., Van Schaeybroeck, S., Longley, D. B., & Johnston, P. G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3599 · Cited by 4,681
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059
Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., & Gianni, L. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.6 · Cited by 3,868
Nanoparticles in Photodynamic Therapy
Lucky, S. S., Soo, K. C., & Zhang, Y. (2015) · Chemical Reviews · doi:10.1021/cr5004198 · Cited by 2,999
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
Liu, Y., Bhattarai, P., Dai, Z., & Chen, X. S. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00618k · Cited by 2,936
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
Quideau, S., Deffieux, D., Douat, C., & Pouységu, L. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201000044 · Cited by 2,874
Apoptosis in cancer: from pathogenesis to treatment
Wong, R. S. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-87 · Cited by 2,836
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆
Slowing, I. I., Vivero-Escoto, J. L., Wu, K. C. ‐., & Lin, V. S. ‐. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.012 · Cited by 2,655
Research works printed but not linked: 4
- Kazeminava, 2023, Crosslinking Chitosan with Silver-Sulfur Doped Graphene Quantum Dots: an Effictive Antibacterial Nanocomposite Hydrogel Films, J. Polym. Environ., 12
- Shah, 2012, Synthesis, characterization and applications of bimetallic (Au-Ag, Au-Pt, Au-Ru) alloy nanoparticles, Rev. Adv. Mater. Sci., 30, 133
- Pylak-Piwko, 2017, Side effects of drugs used in cancer chemotherapy, Journal of Education, Health Sport, 7, 1434
- Zhou, 2008, Compact fuzzy rules induction and feature extraction using SVM with particle swarms for breast cancer treatments, 2008 IEEE Congress on Evolutionary Computation (IEEE World Congress on, Comput. Intell., 1469
Cited by
Sorted by citations
Hosseini, M., Moghaddam, L., Barner, L., Cometta, S., Hutmacher, D. W., & Savi, F. M. (2024) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2024.101908 · Cited by 189
Zeng, Y., Mao, S., Huang, B., Ye, X., & Tian, J. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2024.110333 · Cited by 44
Zuo, Y., Zhu, F., Jiang, S., Sui, Z., & Kong, X. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2024.110419 · Cited by 30
Cheng, S., Wu, C.-H., Tsai, Y., Song, J., Chen, H.-M., Yeh, T., Shen, C.-T., Chiang, J.-C., Lee, H.-M., Huang, K., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.01.066 · Cited by 29
Chen, Y., Lin, Y., Liu, Z., Zhang, Y., Hu, Z., Ai, M., Shen, Y., Lian, D., Wang, C., Liu, X., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101856 · Cited by 28
Metadata
- Authors
- Ghasemian, M., Kazeminava, F., Naseri, A., Mohebzadeh, S., Abbaszadeh, M., Kafil, H. S., & Ahmadian, Z.
- Affiliations
- Lorestan University of Medical Sciences (IR)
- Tabriz University of Medical Sciences (IR)
- University of Mohaghegh Ardabili (IR)
- Corresponding author
- Kafil, Hossein Samadi
- Ahmadian, Zainab
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 166
- Pages
- 115328
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4385847696
- Cited by
- 55
- References
- 213
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 15 · 2023: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Lorestan University of Medical Sciences
- Tabriz University of Medical Sciences
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Chemistry › Organic Chemistry › Tannin, Tannase and Anticancer Activities
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- tannic acid, polyphenols, cancer therapy, anticancer activity, chemotherapy, drug delivery systems, nanoparticles, hydrogels, photothermal therapy, chemodynamic therapy, Fe3+ complexes, theranostics, multidrug resistance
- MeSH terms
- Biocompatible Materials, Humans, Neoplasms, Tannins, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
