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Cue-Induced Brain Activity in Pathological Gamblers
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Background Previous studies using functional magnetic resonance imaging (fMRI) have identified differential brain activity in healthy subjects performing gambling tasks and in pathological gambling (PG) subjects when exposed to motivational and emotional predecessors for gambling as well as during gambling or response inhibition tasks. The goal of the present study was to determine if PG subjects exhibit differential brain activity when exposed to visual gambling cues. Methods Ten male DSM-IV-TR PG subjects and 10 matched healthy control subjects underwent fMRI during visual presentations of gambling-related video alternating with video of nature scenes. Results Pathological gambling subjects and control subjects exhibited overlap in areas of brain activity in response to the visual gambling cues; however, compared with control subjects, PG subjects exhibited significantly greater activity in the right dorsolateral prefrontal cortex (DLPFC), including the inferior and medial frontal gyri, the right parahippocampal gyrus, and left occipital cortex, including the fusiform gyrus. Pathological gambling subjects also reported a significant increase in mean craving for gambling after the study. Post hoc analyses revealed a dissociation in visual processing stream (dorsal vs. ventral) activation by subject group and cue type. Conclusions These findings may represent a component of cue-induced craving for gambling or conditioned behavior that could underlie pathological gambling.
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“toutes les conduites addictives ont pour voie finale commune les voies dopaminergiques issues du noyau tegmental ventral du thalamus se projetant sur le nucleus accumbens.”
From Avant-propos : Les addictions sans drogues (2008) · cites this paper as [3]
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“Le système de récompense impliqué dans les conduites addictives comprend pour l'ensemble des conduites addictives le thalamus, l'amygdale, le nucleus accumbens et le cortex préfrontal [3, 9].”
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Metadata
- Authors
- Crockford, D. N., Goodyear, B., Edwards, J., Quickfall, J., & el-Guebaly, N.
- Affiliations
- University of Calgary (CA)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 58
- Issue
- 10
- Pages
- 787-795
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2083386892
- Cited by
- 375
- References
- 66
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 3 · 2023: 12 · 2022: 12 · 2021: 17 · 2020: 55 · 2019: 16 · 2018: 22 · 2017: 15 · 2016: 22 · 2015: 18 · 2014: 29 · 2013: 25 · 2012: 29
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Libraries and Cultural Resources (University of Calgary) (submittedVersion)
- Libraries and Cultural Resources (University of Calgary)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- gambling addiction, gambling cues, cue-induced craving, dorsolateral prefrontal cortex, parahippocampal gyrus, fusiform gyrus, visual processing streams, dorsal and ventral visual streams, conditioned behavior, brain activity
- MeSH terms
- Adult, Brain, Brain Mapping, Cerebral Cortex, Cues, Gambling, Humans, Disruptive, Impulse Control, and Conduct Disorders, Magnetic Resonance Imaging, Male, Middle Aged, Motivation, Reward, Videotape Recording, Visual Perception, Behavior, Addictive, Prefrontal Cortex, Imaging, Three-Dimensional
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