Cited by 318Neurogenesis and neuroplasticity mechanismsTreatment of Major DepressionNeuroscience and Neuropharmacology Research

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Agomelatine, a New Antidepressant, Induces Regional Changes in Hippocampal Neurogenesis

Banasr, Mounira, Soumier, Amélie, Hery, Micheline, Mocaër, Elisabeth, Daszuta, Annie·2006·Biological Psychiatry

DOI 10.1016/j.biopsych.2005.11.025

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Abstract

Background Antidepressant treatments increase neural plasticity and adult neurogenesis, especially in the hippocampus. Here, we determined the effects of agomelatine (S-20098), a new antidepressant, on various phases of neurogenesis in the dentate gyrus of adult rat.Methods Animals were injected with agomelatine for different time periods. Immunostaining for bromodeoxyuridine, neuron specific nuclear protein, and glial fibrillary acid protein, as well as for the highly polysialylated form of neuronal cell adhesion molecule and doublecortin, was used to detect changes in cell proliferation, neurogenesis, and survival. Cell death was estimated by terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end labeling and cresyl violet staining.Results Chronic (3 weeks) but not acute (4 hours) or subchronic (1 week) administration of agomelatine increased cell proliferation and neurogenesis in the ventral dentate gyrus, a region notably implicated in response to emotion, which is consistent with the antidepressant-anxiolytic properties of the drug. Extending agomelatine treatment over several weeks, however, increases survival of newly formed neurons in the entire dentate gyrus. Finally, agomelatine treatment does not affect mature granule cells.Conclusions This study shows that an antidepressant can affect differentially various stages of neurogenesis in the dorsal and ventral hippocampus. Altogether, these changes lead to a pronounced augmentation in the total number of new granule cells.

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Stress and Depression
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014

Show all 95 references

Research works printed but not linked: 3

Bertaina-Anglade, 2002, Antidepressant-like action of S 20098 (agomelatine) in the learned helplessness test, Int J Neuropsychopharmacol, 5, S65
Bourin, 2004, Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents, J Psychiatry Neurosci, 29, 126
Loo, 2002, [Pilot study comparing in blind the therapeutic effect of two doses of agomelatine, melatoninergic agonist and selective 5HT2C receptors antagonist, in the treatment of major depressive disorders], Encephale, 28, 356

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Authors: Banasr, M., Soumier, A., Hery, M., Mocaër, E., & Daszuta, A.
Affiliations: Centre National de la Recherche Scientifique (FR)
Institut de Recherches Internationales Servier (France) (FR)
Corresponding author: Daszuta, Annie
ORCID: Banasr, Mounira
Soumier, Amélie
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2006-06
Volume: 59
Issue: 11
Pages: 1087-1096
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2005.11.025
OpenAlex: W1965355495
Cited by: 318
References: 95
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 15 · 2021: 4 · 2020: 10 · 2019: 14 · 2018: 23 · 2017: 12 · 2016: 21 · 2015: 13 · 2014: 27 · 2013: 17 · 2012: 20
FWCI: 5.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: agomelatine, antidepressants, adult hippocampal neurogenesis, dentate gyrus, cell proliferation, neuronal survival, granule cells, neuroplasticity, chronic drug administration
MeSH terms: Acetamides, Doublecortin Domain Proteins, Doublecortin Protein, Animals, Bromodeoxyuridine, Cell Count, Cell Survival, Fluorescent Antibody Technique, Glial Fibrillary Acidic Protein, Hippocampus, Hypnotics and Sedatives, Male, Microtubule-Associated Proteins, Naphthalenes, Neurons, Neuropeptides, Nuclear Proteins, Time Factors, Cell Death, Rats, Wistar, Dentate Gyrus, Neural Cell Adhesion Molecule L1, Cell Proliferation, Rats

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Agomelatine, a New Antidepressant, Induces Regional Changes in Hippocampal Neurogenesis

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