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Bruno, V., Caraci, F., Copani, A., Matrisciano, F., Nicoletti, F., & Battaglia, G. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.044 · Cited by 71 · see citing works

Effects of 5-HT-7 receptor ligands on memory and cognition

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Wnt Signaling in the Hippocampus in Relation to Neurogenesis, Neuroplasticity, Stress and Epigenetics

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Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients

Dvojkovic, A., Perković, M. N., Šagud, M., Erjavec, G. N., Peleš, A. M., Štrac, D. Š., Ćusa, B. V., Tudor, L., Kušević, Z., Konjevod, M., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110016 · Cited by 37 · see citing works

Repetitive high-frequency transcranial magnetic stimulation reverses depressive-like behaviors and protein expression at hippocampal synapses in chronic unpredictable stress-treated rats by enhancing endocannabinoid signaling

Xue, S., Xue, F., Ma, Q., Wang, S., Wang, Y., Tan, Q., Wang, H., Zhou, C., & Peng, Z. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172738 · Cited by 35 · see citing works

Chronic 5-HT3 receptor antagonism ameliorates seizures and associated memory deficit in pentylenetetrazole-kindled mice

Mishra, A., & Goel, R. K. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.010 · Cited by 34 · see citing works

Vortioxetine Prevents Lipopolysaccharide-Induced Memory Impairment Without Inhibiting the Initial Inflammatory Cascade

Alboni, S., Benatti, C., Colliva, C., Radighieri, G., Blom, J. M. C., Brunello, N., & Tascedda, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.603979 · Cited by 28 · see citing works

Selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity

Ishikawa, T., Okano, M., Minami, A., Tsunekawa, H., Satoyoshi, H., Tsukamoto, Y., Takahata, K., & Muraoka, S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.10.032 · Cited by 27 · see citing works

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices

Dale, E., Grunnet, M., Pehrson, A. L., Frederiksen, K., Larsen, P. H., Nielsen, J., Stensbøl, T. B., Ebert, B., Yin, H., Lu, D., et al. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.025 · Cited by 27 · see citing works

Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures

Waller, J. A., Chen, F., & Sánchez, C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.012 · Cited by 25 · see citing works

Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway

Jung, H. Y., Kim, D. W., Nam, S. M., Kim, J. W., Chung, J. Y., Won, M.-H., Seong, J. K., Yoon, Y. S., Yoo, D. Y., & Hwang, I. K. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.09.006 · Cited by 23 · see citing works

In vivo and in vitro effects of vortioxetine on molecules associated with neuroplasticity

Kugathasan, P., Waller, J. A., Westrich, L., Abdourahman, A., Tamm, J. A., Pehrson, A. L., Dale, E., Gulinello, M. E., Sánchez, C., & Li, Y. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116667710 · Cited by 22 · see citing works

Effect of vortioxetine in subjects with major depressive and alcohol use disorders: a 6-month retrospective analysis

Nicola, M. D., Pepe, M., Panaccione, I., Moccia, L., Dattoli, L., Molinaro, M., Sani, G., Janiri, L., & McIntyre, R. S. (2020) · CNS Spectrums · doi:10.1017/s109285292000173x · Cited by 22 · see citing works

Hippocampal PPARα Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant

Wang, Y., Gu, J., Liu, L., Liu, Y., Tang, W., Ji, C.-H., Guan, W., Zhao, X., Sun, Y., Xu, D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.673221 · Cited by 20 · see citing works

Vortioxetine Reduces Marble Burying but Only Transiently Enhances Social Interaction Preference in Adult Male BTBR T+Itpr3tf/J Mice

Witt, N. A., Lee, B., Ghent, K., Zhang, W. Q., Pehrson, A. L., Sánchez, C., & Gould, G. G. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00386 · Cited by 20 · see citing works

Serotonin and exercise-induced brain plasticity

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Determination of vortioxetine in human serum and saliva samples by HPLC–DAD and HPLC–MS

Wróblewski, K., Petruczynik, A., Buszewski, B., Szultka‐Młyńska, M., Karakuła‐Juchnowicz, H., & Waksmundzka‐Hajnos, M. (2016) · Acta Chromatographica · doi:10.1556/1326.2017.29.3.02 · Cited by 16 · see citing works

The serotonin system in the hippocampus CA3 involves in effects of CSDS on social recognition in adult female mandarin voles (Microtus mandarinus)

Wang, L., He, Z., Zhu, Z., Yuan, W., Cai, W., Li, L., Zhang, J., Hou, W., Yang, Y., Zhang, X., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109704 · Cited by 16 · see citing works

Sub-chronic vortioxetine (but not escitalopram) normalizes brain rhythm alterations and memory deficits induced by serotonin depletion in rats

Riga, M. S., Sánchez, C., Celada, P., & Artigas, F. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108238 · Cited by 14 · see citing works

Chemogenetic activation of prefrontal astroglia enhances recognition memory performance in rat

Delcourte, S., Bouloufa, A., Rovera, R., Betry, C., Abrial, E., Dkhissi‐Benyahya, O., Heinrich, C., Marcy, G., Raineteau, O., Haddjeri, N., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115384 · Cited by 13 · see citing works

Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice

Tanaka, T., Ago, Y., Umehara, C., Imoto, E., Hasebe, S., Hashimoto, H., Takuma, K., & Matsuda, T. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw115 · Cited by 13 · see citing works

Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders

the ILDE Study Group, Fattori, A., Neri, L., Bellomo, A., Vaggi, M., & Mencacci, C. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1595-4 · Cited by 12 · see citing works

Gene expression of serotonergic markers in peripheral blood mononuclear cells of patients with late-onset Alzheimer's disease

Neshan, M., Campbell, A., Malakouti, S. K., Zareei, M., & Ahangari, G. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04716 · Cited by 12 · see citing works

Vortioxetine Improves Context Discrimination in Mice Through a Neurogenesis Independent Mechanism

Felice, D., Guilloux, J., Pehrson, A. L., Li, Y., Mendez‐David, I., Gardier, A. M., Sánchez, C., & David, D. J. P. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00204 · Cited by 12 · see citing works

Molecular pathways linking the serotonin transporters (SERT) to depressive disorder: from mechanisms to treatments

Murthy, M. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.009 · Cited by 10 · see citing works

Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression

Hariom, Kumari, P., Chaturvedi, S., Shrivastav, S., Maratha, S. R., & Walia, V. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173930 · Cited by 9 · see citing works

Use of vortioxetine in different neurological fields: a systematic review and future perspectives

Verrienti, G., Colonna, I., & Raccagni, C. (2025) · Neurological Sciences · doi:10.1007/s10072-025-07987-1 · Cited by 9 · see citing works

Propriétés pharmacologiques de la vortioxetine et leurs conséquences pré-cliniques

David, D. J. P., Tritschler, L., Guilloux, J., Gardier, A. M., Sánchez, C., & Raphaël Gaillard, B. (2016) · L Encéphale · doi:10.1016/s0013-7006(16)30015-x · Cited by 8 · see citing works

NLX-112, a highly selective 5-HT1A receptor agonist: Effects on body temperature and plasma corticosterone levels in rats

Newman‐Tancredi, A., Depoortère, R., Carilla-Durand, E., Tarayre, J. P., Kleven, M. S., Koek, W., Bardin, L., & Varney, M. A. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.11.002 · Cited by 7 · see citing works

Anhedonia as a basic syndrome and a target for treatment for depressive disorder

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5‐HT 3 A receptors maintain hippocampal LTP in a CB 1 and GABA A receptor‐ dependent manner for spatial memory

Yu, Y., Li, J., He, X., Lai, Z., Hao, R., Qi, Y., Cao, D., Fu, M., Ma, H., Xie, Q., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15793 · Cited by 6 · see citing works

Vortioxetine improved social and cognitive deficits in acute ketamine model of schizophrenia in rats

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Antistress and antidepressant properties of dapoxetine and vortioxetine

Ratajczak, P., Kus, K., Zielińska‐Przyjemska, M., Skórczewska, B., Zaprutko, T., Kopciuch, D., Paczkowska, A., & Nowakowska, E. (2020) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2020-020 · Cited by 6 · see citing works

Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain

Yücel, N. T., Kandemir, Ü., Üçel, U. İ., Özkay, Ü. D., & Can, Ö. D. (2023) · Biomedicines · doi:10.3390/biomedicines11041137 · Cited by 6 · see citing works

Acute dosing of vortioxetine strengthens event-related brain activity associated with engagement of attention and cognitive functioning in rats

Laursen, B., Bundgaard, C. H., Graversen, C., Grupe, M., Sánchez, C., Leiser, S. C., Sørensen, H. B. D., Drewes, A. M., & Bastlund, J. F. (2017) · Brain Research · doi:10.1016/j.brainres.2017.03.024 · Cited by 6 · see citing works

In vivo electrophysiological study of the targeting of 5‐HT3 receptor‐expressing cortical interneurons by the multimodal antidepressant, vortioxetine

Schweimer, J. V., Brouard, J. T., Li, Y., Sánchez, C., & Sharp, T. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15623 · Cited by 6 · see citing works

Looking back (and in)to the future: A personal reflection on ‘Serotonin autoreceptor function and antidepressant drug action’ (Hjorth et al., 2000)

Hjorth, S. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116647621 · Cited by 5 · see citing works

Novel Object Recognition Test in Rodents:

Bouët, V., Fréret, T., Schumann‐Bard, P., & Boulouard, M. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-812012-5.00027-6 · Cited by 4 · see citing works

A Randomized Controlled Study of Efficacy and Cognitive Function Improvement of Vortioxetine and Escitalopram in Patients with Depression in Chinese Han Nationality

Ye, X., Xu, P., Jiao, J., Zhao, H., Jin, K., Zhang, S., Pan, F., Chen, J., Jiang, H., Hu, J., et al. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s491768 · Cited by 3 · see citing works

Vortioxetine’s cardiovascular profile as a relevant feature for the management of major depressive disorder in comorbidity with organic diseases

Dell’Osso, B. M., Blasi, G., Serafini, G., Serrati, C., Bianchetti, A., Porto, I., Forleo, G. B., Pugliese, A., Mastrostefano, A., & Nicoletti, F. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2602193 · Cited by 3 · see citing works

Stable rat models in constipation with depression and anxiety: evaluation and validation

Liu, J., Li, S., Bian, C., Mi, H., He, T., Qian, H., & Zhang, D. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1745331 · Cited by 3 · see citing works

Vortioxetine improved schizophrenia‐like behavioral deficits in a Poly I:C‐induced maternal immune activation model of schizophrenia in rats

Taşkıran, M., Taskiran, S. Y., Ünal, G., Bozkurt, N. M., & Gölgeli, A. (2024) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.13028 · Cited by 3 · see citing works

The Discovery of the Antidepressant Vortioxetine and the Research that Uncovered Its Potential to Treat the Cognitive Dysfunction Associated with Depression

Bang‐Andersen, B., Olsen, C. K., & Sánchez, C. (2016) · doi:10.1002/9783527800315.ch9 · Cited by 3 · see citing works

Possible Interaction of Oxidative Stress, Inflammatory, and Nitric Oxide Pathways in the Anticonvulsant Effect of Vortioxetine on Pentylenetetrazole-Induced Seizures in Rats

Taşkıran, A. Ş., & Filiz, A. K. (2024) · Neurochemical Journal · doi:10.1134/s1819712424700478 · Cited by 1 · see citing works

The Effects And Possible Mechanisms of Vortioxetine on Pentylenetetrazole-Induced Seizures In RatsPreprint

Taşkıran, A. Ş., & Filiz, A. K. (2021) · Research Square · doi:10.21203/rs.3.rs-805264/v1

Long-term effectiveness of vortioxetine on achievement of personal goals and work productivity in patients with major depressive disorder: The VGOAL-J study

Watanabe, K., Sumiyoshi, T., Kato, M., Kikuchi, T., Moriguchi, Y., Åström, D. O., & Christensen, M. C. (2025) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2025.100955

Additional file 2 of 5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption

Ma, J., Wang, R., Chen, Y., Wang, Z., & Dong, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26566064

Additional file 1 of 5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption

Ma, J., Wang, R., Chen, Y., Wang, Z., & Dong, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26566061

Hepatic Inflammation and Apoptosis in Socially Isolated Rats: Effects of Vortioxetine Treatment

Arı, N. S., Akkuş, M., Solak, H., Koca, R. Ö., & GÖRMÜŞ, İ. S. (2026) · Iranian journal of pharmaceutical research · doi:10.5812/ijpr-170887

The multimodal antidepressant vortioxetine exerts therapeutic effects in male mice which is associated with normalization of hippocampal SIK2/CRTC1-related signaling and require hippocampal CRTC1

Xu, H., Fan, H., Ding, E.-H., Hou, P., Jiang, B., & Zhu, W.-B. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1837566

P.2.f.015 Omega-3 polyunsaturated fatty acids for major depressive disorder: an updated meta-analysis of randomised clinical trials

Mocking, R. J. T., Assies, J., Ruhé, H. G., Koeter, M. W. J., & Schene, A. H. (2015) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(15)30594-0 · Cited by 2 · see citing works

Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus

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Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

Mørk, A., Montezinho, L. P., Miller, S., Trippodi-Murphy, C., Plath, N., Li, Y., Gulinello, M. E., & Sánchez, C. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.01.019 · Cited by 298 · see citing works

Relative short-term efficacy and acceptability of agomelatine versus vortioxetine in adult patients suffering from major depressive disorder

Kennedy, S. H., Grouin, J., Cadour, S., Robert, V., & Picarel-Blanchot, F. (2016) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(16)31450-x · Cited by 1 · see citing works

P.2.e.007 Antipsychotic drugs in depression: the unexplored role of neuroplasticity

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