The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work
Abstract
Administration of benzodiazepines or serotonin reuptake inhibitors in combination with behavior therapy for the treatment of many anxiety disorders has generally lead to only modest gains. In this article we suggest that pharmacotherapy aimed not at treating the symptoms of anxiety but instead aimed at improving the learning that takes place in exposure therapy might actually improve the effectiveness of exposure therapy. This idea was based on animal work showing that the partial N-methyl-D-aspartate (NMDA) agonist D-cycloserine (DCS) facilitated extinction of fear when given either before or shortly after exposure to fearful cues, reduced return of fear that is normally seen when extinction training is followed by stress, and led to generalized extinction, where DCS given in combination with exposure to one fearful cue led to extinction to another cue previously paired with the same aversive event. These finding suggested that DCS might facilitate exposure-based psychotherapy, which was verified in a small clinical study showing that DCS facilitated exposure therapy for fear of heights in a well-controlled virtual reality environment.
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“Similar impairments of fear recall and additional enhancements of fear extinction are observed following acute antibiotic exposure in humans and rodents (Bach et al., 2018;Davis et al., 2006;Rodrigues et al., 2014).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Davis et al., 2006
In the citing paper
“Preclinical research has demonstrated that DCS facilitates extinction learning and memory in rodent models (Davis et al, 2006; Ledgerwood et al, 2003; Walker et al, 2002).”
From D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial (2014) · cites this paper as Davis et al, 2006
Citations
Cites
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Integrative activity of the brain
Konorski, J. (1967) · University of Chicago Press eBooks · Cited by 2,043
Integrative activity of the brain
Konorski, J. (1967) · Cited by 1,372
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063
Self-citationBehavioral and Neural Analysis of Extinction
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918
Self-citationMiserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824 · cited 1×
“For example, Miserendino et al (1990) found that blockade of the NMDA glutamate receptor in the amygdala, known to be critical for fear conditioning, blocked the acquisition but not the expression of conditioned fear.”
BackgroundSelf-citationWalker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815
Self-citationContextual control of the extinction of conditioned fear
Bouton, M. E., & Bolles, R. C. (1979) · Learning and Motivation · doi:10.1016/0023-9690(79)90057-2 · Cited by 796
Reinstatement of fear to an extinguished conditioned stimulus.
Rescorla, R. A., & Heth, C. D. (1975) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.1.1.88 · Cited by 768
Effectiveness of computer-generated (virtual reality) graded exposure in the treatment of acrophobia
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.4.626 · Cited by 694
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
“Exposure therapy is highly effective (Foa, 2006), however, there is the possibility of improving the effectiveness and/or shortening the duration of treatment if extinction learning could be facilitated with pharmacological or other methods (Davis et al, 2006b).”
BackgroundFear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466
“It is now well established that the NMDA receptor partial agonist d-cycloserine, which facilitates extinction in rodents (Davis et al 2006), augments the clinical response to cognitive behavioral therapy (CBT) for a number of anxiety disorders (for review, see Ganasen et al 2010).”
BackgroundRauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397
Psychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272
Metadata
- Authors
- Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R.
- Affiliations
- Emory University (US)
- UNSW Sydney (AU)
- Corresponding author
- Davis, Michael
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 60
- Issue
- 4
- Pages
- 369-375
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2162692973
- Semantic Scholar
- 4b2fc25139b7de7848a13aa43da593a50f3d77c0
- Cited by
- 498
- References
- 43
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 13 · 2020: 10 · 2019: 22 · 2018: 19 · 2017: 25 · 2016: 14 · 2015: 36 · 2014: 32 · 2013: 38 · 2012: 48
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21mh055555-02)
- National Institute of Mental Health (MH55555, MH-047840, MH069884, K01MH069884)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- D-cycloserine, fear extinction, NMDA receptor agonist, exposure therapy, anxiety disorders, fear of heights, virtual reality exposure, return of fear, phobia treatment
- MeSH terms
- Animals, Antimetabolites, Conditioning, Classical, Cycloserine, Extinction, Psychological, Fear, Humans, Phobic Disorders, Cognitive Behavioral Therapy, Receptors, N-Methyl-D-Aspartate
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