Psychobiology and molecular genetics of resilience
Open accessAbstract
Every individual experiences stressful life events. In some cases acute or chronic stress leads to depression and other psychiatric disorders, but most people are resilient to such effects. Recent research has begun to identify the environmental, genetic, epigenetic and neural mechanisms that underlie resilience, and has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. These changes shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour, which together are thought to mediate successful coping with stress.
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Glutamatergic and noradrenergic neuronal signalling and dopaminergic connections participate in neuronal regulation in the fear circuit.
“Similarly, glutamatergic and noradrenergic neuronal signalling (203) and dopaminergic connections participate in neuronal regulation in the fear circuit.”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [203]
The reward pathway/circuit in the brain has been associated with trait optimism, which has been associated with resilience after stress.
“the reward pathway/circuit in the brain has been associated with trait optimism, which has been associated with resilience after stress (203).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [203]
Stressful life events have been documented to increase risk for psychiatric illness in carriers of distinct variants of genes such as 5HTT, FKBP5 and CRH1 but not in carriers of the alternative variants of these same genes.
“For example, stressful life events have been documented to increase risk for psychiatric illness in carriers of distinct variants of genes such as 5HTT, FKBP5 and CRH1 but not in carriers of the alternative variants of these same genes [see below, and reviewed recently by Feder et al. 8].”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [8]
Resilience in humans is an active adaptive process, not merely the absence of pathological responses seen in more susceptible individuals.
“Recent reports indicate that resilience in humans represents an active, adaptive process, and not simply the absence of pathological responses that occur in more susceptible individuals1, 2”
From Neurobiology of resilience (2012) · cites this paper as [2]
Social support by proximal others is a key resilience factor promoting successful coping with and adaptation to psychosocial stress.
“For instance, social support by proximal others has been identified as a key resilience factor promoting successful coping with and adaptation to psychosocial stress (2).”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [2]
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- Authors
- Feder, A., Nestler, E. J., & Charney, D. S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Feder, Adriana
- Venue
- Nature Reviews Neuroscience
- Published
- 2009-06
- Volume
- 10
- Issue
- 6
- Pages
- 446-457
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC2833107
- OpenAlex
- W2013309206
- Cited by
- 1,272
- References
- 155
- Citations by year
- 2026: 36 · 2025: 47 · 2024: 56 · 2023: 63 · 2022: 67 · 2021: 61 · 2020: 138 · 2019: 76 · 2018: 95 · 2017: 85 · 2016: 85 · 2015: 78 · 2014: 76 · 2013: 72 · 2012: 80
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH051399, P50MH066172)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- stress resilience, stress coping, neural circuits, neuromodulators, molecular pathways, epigenetics, genetic factors, depression, fear, emotional reactivity, social behavior
- MeSH terms
- Adaptation, Psychological, Animals, Environment, Humans, Hypothalamo-Hypophyseal System, Molecular Biology, Neural Pathways, Neurosciences, Pituitary-Adrenal System, Psychology, Stress, Psychological
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