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Cited by 34Bipolar Disorder and TreatmentPersonality Disorders and PsychopathologyChild and Adolescent Psychosocial and Emotional Development

Association of bipolar and substance use disorders in parents of adolescents with bipolar disorder

Wilens, Timothy E., Biederman, Joseph, Adamson, Joel, Monuteaux, Michael, Henin, Aude, Sgambati, Stephanie, Santry, Alison, Faraone, Stephen V.·2007·Biological Psychiatry
DOI 10.1016/j.biopsych.2006.11.022
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Abstract

Background We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism.Methods We studied 108 adolescent BPD probands with 187 parents (34 with SUD and 58 parents) and 96 control probands with 177 parents with structured interviews. We compared the prevalence of BPD and SUD with Cox proportional hazards models with time to onset of BPD or SUD as the dependent variable and proband diagnosis (Control, BPD, or BPD+SUD) as the independent variable.Results The parents of the proband youth with BPD (without SUD) and BPD+SUD were more likely to develop BPD than the parents of control subjects [omnibus test chi2=10.18, p=.006]; we found no differences between the two bipolar groups. Parents of proband youth with BPD and with BPD+SUD were more likely than relatives of control subjects to develop SUD [omnibus test chi2=14.69, p<.001]; however, we found no differences between the parents of the two proband bipolar groups. Within the parents of proband youth with BPD+SUD, we found higher risk of SUD in parents with BPD than in those without BPD [chi2=8.39, p=.004], although the frequency of BPD was low in this group of parents.Conclusions Bipolar disorder and SUD are prevalent in the first-degree relatives of adolescents with BPD. Adults with BPD were more likely to manifest SUD with preliminary evidence of BPD and SUD cosegregation.

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Authors
Wilens, T. E., Biederman, J., Adamson, J., Monuteaux, M., Henin, A., Sgambati, S., Santry, A., & Faraone, S. V.
Affiliations
  • Harvard University (US)
  • Massachusetts General Hospital (US)
  • SUNY Upstate Medical University (US)
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2007-07
Volume
62
Issue
2
Pages
129-134
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2006.11.022
OpenAlex
W2031590548
Cited by
34
References
47
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2019: 1 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 4
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (K24DA016264, R01DA012945, R01 DA12945, U10DA015831, U10-DA15831)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
bipolar disorder, substance use disorders, familial risk, adolescents, parents, first-degree relatives, co-segregation, onset time
MeSH terms
Adolescent, Psychology, Adolescent, Adult, Age Factors, Aged, Bipolar Disorder, Family Health, Female, Humans, Male, Middle Aged, Parents, Psychiatric Status Rating Scales, Risk Factors, Comorbidity, Prevalence, Proportional Hazards Models, Diagnosis, Dual (Psychiatry), Substance-Related Disorders, Diagnostic and Statistical Manual of Mental Disorders

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