Adult Outcomes of Childhood Dysregulation: A 14-year Follow-up Study
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Objective Using a general population sample, the adult outcomes of children who presented with severe problems with self-regulation defined as being concurrently rated highly on attention problems, aggressive behavior, and anxious-depression on the Child Behavior Checklist-Dysregulation Profile (CBCL-DP) were examined. Method Two thousand seventy-six children from 13 birth cohorts 4 to 16 years of age were drawn from Dutch birth registries in 1983. CBCLs were completed by parents at baseline when children from the different cohorts were 4 to 16 years of age and sampled every 2 years for the next 14 years. At year 14 the CBCL and DSM interview data were collected. Logistic regression was used to compare and contrast outcomes for children with and without dysregulation, as measured by the latent-class-defined CBCL-DP. Sex and age were covaried and concurrent DSM diagnoses were included in regression models. Results Presence of childhood CBCL-DP at wave 1 was associated with increased rates of adult anxiety disorders, mood disorders, disruptive behavior disorders, and drug abuse 14 years later. After controlling for co-occurring disorders in adulthood, associations with anxiety and disruptive behavior disorders with the CBCL-DP remained, whereas the others were not significant. Conclusions A child reported to be in the CBCL-DP class is at increased risk for problems with regulating affect, behavior, and cognition in adulthood.
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A population-based study of 2076 children found that those matching the Child Behavior Checklist 'dysregulation profile' had increased rates of anxiety disorders and disruptive behavior disorders in adulthood compared to non-dysregulated children.
“A population-based study of 2076 children found that those matching the Child Behavior Checklist ‘dysregulation profile’, had increased rates of anxiety disorders and disruptive behavior disorders in adulthood compared to non-dysregulated children (67).”
From Emotion Dysregulation in Attention Deficit Hyperactivity Disorder (2014) · cites this paper as [67]
In a comparison, 55 adults with persistent ADHD showed higher rates of emotion dysregulation (42-72%) than 80 adults with remitted ADHD (23-45%), although both groups differed from healthy subjects.
“In such a comparison, 55 adults with persistent ADHD showed higher rates of emotion dysregulation (42-72%, depending on specific symptoms) than 80 adults with remitted ADHD (23-45%), although both groups differed from healthy subjects (70).”
From Emotion Dysregulation in Attention Deficit Hyperactivity Disorder (2014) · cites this paper as [70]
The Introduction describes a follow-up of childhood dysregulation in a general-population sample, not a comparison of adults with persistent and remitted ADHD. Searches for the stated group sizes, percentages, and comparison with healthy subjects found no passage in our copy reporting them. Page numbers were not available for the indexed passages. (LLM, conf=0.76)
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- Authors
- Althoff, R. R., Verhulst, F. C., Rettew, D. C., Hudziak, J. J., & van der Ende, J.
- Affiliations
- University of Vermont (US)
- Erasmus MC (NL)
- Corresponding author
- Althoff, Robert R.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 49
- Issue
- 11
- Pages
- 1105-1116.e1
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC2965164
- OpenAlex
- W2032901980
- Cited by
- 303
- References
- 61
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 23 · 2023: 17 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 26 · 2018: 24 · 2017: 23 · 2016: 15 · 2015: 17 · 2014: 18 · 2013: 20 · 2012: 10
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institute of Mental Health (K08MH082116)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- adult outcomes, anxiety disorders, mood disorders, disruptive behavior disorders, drug abuse, attention deficits, aggression, anxious depression, latent class analysis, longitudinal follow-up, birth cohort
- MeSH terms
- Adolescent, Adult, Antisocial Personality Disorder, Behavioral Symptoms, Child, Child Behavior Disorders, Child, Preschool, Female, Follow-Up Studies, Humans, Male, Netherlands, Psychiatric Status Rating Scales, Logistic Models, Outcome Assessment, Health Care, Mood Disorders, Substance-Related Disorders, Young Adult, Checklist
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