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Major Depression in Late Life Is Associated with Both Hypo- and Hypercortisolemia
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Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Robins, L. N. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780290015001 · Cited by 5,219
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653
Burnout, Perceived Stress, and Cortisol Responses to Awakening
Pruessner, J. C., Hellhammer, D. H., & Kirschbaum, C. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00012 · Cited by 822
Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578
O'Brien, J. T. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2081 · Cited by 409
DST Studies in Psychotic Depression: A Meta-Analysis
Nelson, J. C., & Davis, J. M. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1497 · Cited by 356
Research works printed but not linked: 39
- Beekman, 1999, Review of community prevalence of depression in later life, Br J Psychiatry, 174, 307, 10.1192/bjp.174.4.307 · DOI · Paper page
- Beekman, 1997, Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): Results from a community-based sample of older subjects in the Netherlands, Psychol Med, 27, 231, 10.1017/S0033291796003510 · DOI · Paper page
- Bremmer, 2006, Depression in older age is a risk factor for first ischemic cardiac events, Am J Geriatr Psychiatry, 14, 523, 10.1097/01.JGP.0000216172.31735.d5 · DOI
- Brouwer, 2005, Thyroid and adrenal axis in major depression: A controlled study in outpatients, Eur J Endocrinol, 152, 185, 10.1530/eje.1.01828 · DOI
- Charney, 2003, Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life, Arch Gen Psychiatry, 60, 664, 10.1001/archpsyc.60.7.664 · DOI · Paper page
- Cleare, 2004, The HPA axis and the genesis of chronic fatigue syndrome, Trends Endocrinol Metab, 15, 55, 10.1016/j.tem.2003.12.002 · DOI · Paper page
- Deeg, 2002, Attrition in the Longitudinal Aging Study Amsterdam, J Clin Epidemiol, 55, 319, 10.1016/S0895-4356(01)00475-9 · DOI · Paper page
- Dhillo, 2002, Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic–pituitary–adrenal axis, Eur J Endocrinol, 146, 231, 10.1530/eje.0.1460231 · DOI
- 2001, Adult Treatment Panel III, JAMA, 285, 2486
- Folstein, 1975, “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res, 12, 189, 10.1016/0022-3956(75)90026-6 · DOI · Paper page
- Frasure-Smith, 1995, Depression and 18-month prognosis after myocardial infarction, Circulation, 91, 999, 10.1161/01.CIR.91.4.999 · DOI · Paper page
- Frodl, 2006, Reduced hippocampal volume correlates with executive dysfunctioning in major depression, J Psychiatry Neurosci, 31, 316
- Girod, 2004, Does altered glucocorticoid homeostasis increase cardiovascular risk?, Cardiovasc Res, 64, 217, 10.1016/j.cardiores.2004.07.006 · DOI · Paper page
- Griep, 1998, Function of the hypothalamic–pituitary–adrenal axis in patients with fibromyalgia and low back pain, J Rheumatol, 25, 1374
- Heim, 2000, The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders, Psychoneuroendocrinology, 25, 1, 10.1016/S0306-4530(99)00035-9 · DOI · Paper page
- Heuser, 1996, Pituitary–adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects, Am J Psychiatry, 153, 93, 10.1176/ajp.153.1.93 · DOI · Paper page
- Holsboer, 2000, The corticosteroid receptor hypothesis of depression, Neuropsychopharmacology, 23, 477, 10.1016/S0893-133X(00)00159-7 · DOI · Paper page
- Kalmijn, 1998, A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly, J Clin Endocrinol Metab, 83, 3487, 10.1210/jcem.83.10.5164 · DOI · Paper page
- Kirschbaum, 1996, Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults, Life Sci, 58, 1475, 10.1016/0024-3205(96)00118-X · DOI · Paper page
- Lupien, 1999, Increased cortisol levels and impaired cognition in human aging: Implication for depression and dementia in later life, Rev Neurosci, 10, 117, 10.1515/REVNEURO.1999.10.2.117 · DOI · Paper page
- Morrison, 2000, Dehydroepiandrosterone sulfate and psychiatric measures in a frail, elderly residential care population, Biol Psychiatry, 47, 144, 10.1016/S0006-3223(99)00099-2 · DOI
- Musselman, 1998, The relationship of depression to cardiovascular disease: Epidemiology, biology, and treatment, Arch Gen Psychiatry, 55, 580, 10.1001/archpsyc.55.7.580 · DOI · Paper page
- Nemeroff, 1996, The corticotropin-releasing factor (CRF) hypothesis of depression: New findings and new directions, Mol Psychiatry, 1, 336
- O’Brien, 1996, Clinical and magnetic resonance imaging correlates of hypothalamic–pituitary–adrenal axis function in depression and Alzheimer’s disease, Br J Psychiatry, 168, 679, 10.1192/bjp.168.6.679 · DOI · Paper page
- Oldehinkel, 2001, Urinary free cortisol excretion in elderly persons with minor and major depression, Psychiatry Res, 104, 39, 10.1016/S0165-1781(01)00300-6 · DOI
- Otte, 2004, Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study, Biol Psychiatry, 56, 241, 10.1016/j.biopsych.2004.06.003 · DOI
- Pariante, 2001, Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment, Biol Psychiatry, 49, 391, 10.1016/S0006-3223(00)01088-X · DOI · Paper page
- Penninx, 2001, Depression and cardiac mortality: Results from a community-based longitudinal study, Arch Gen Psychiatry, 58, 221, 10.1001/archpsyc.58.3.221 · DOI · Paper page
- Penninx, 2000, Changes in depression and physical decline in older adults: A longitudinal perspective, J Affect Disord, 61, 1, 10.1016/S0165-0327(00)00152-X · DOI
- Radloff, 1997, The CES-D Scale: A self-report depression scale for research in the general population, J Applied Psychol Measurement, 1, 385, 10.1177/014662167700100306 · DOI · Paper page
- Rush, 1996, The dexamethasone suppression test in patients with mood disorders, J Clin Psychiatry, 57, 470, 10.4088/JCP.v57n1006 · DOI
- Sapolsky, 2000, Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders, Arch Gen Psychiatry, 57, 925, 10.1001/archpsyc.57.10.925 · DOI · Paper page
- Sheline, 2003, Neuroimaging studies of mood disorder effects on the brain, Biol Psychiatry, 54, 338, 10.1016/S0006-3223(03)00347-0 · DOI · Paper page
- Sheline, 1996, Hippocampal atrophy in recurrent major depression, Proc Natl Acad Sci U S A, 93, 3908, 10.1073/pnas.93.9.3908 · DOI · Paper page
- Starkman, 2001, Elevated cortisol levels in Cushing’s disease are associated with cognitive decrements, Psychosom Med, 63, 985, 10.1097/00006842-200111000-00018 · DOI
- Thomas, 2004, Depression and vascular disease: What is the relationship?, J Affect Disord, 79, 81, 10.1016/S0165-0327(02)00349-X · DOI · Paper page
- Vythilingam, 2004, Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment, Biol Psychiatry, 56, 101, 10.1016/j.biopsych.2004.04.002 · DOI · Paper page
- Wilson, 2002, Depressive symptoms, cognitive decline, and risk of AD in older persons, Neurology, 59, 364, 10.1212/WNL.59.3.364 · DOI · Paper page
- Young, 2001, Twenty-four-hour ACTH and cortisol pulsatility in depressed women, Neuropsychopharmacology, 25, 267, 10.1016/S0893-133X(00)00236-0 · DOI · Paper page
Cited by
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Green space and stress: Evidence from cortisol measures in deprived urban communities
Roe, J., Thompson, C., Aspinall, P., Brewer, M., Duff, E., Miller, D., Mitchell, R., & Clow, A. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10094086 · Cited by 674
“Consistent with this finding, in older women depression has been associated with hypocortisolemia whilst, in older men, depression was associated with hypercortisolemia [18].”
ResultKessler, R. C., Birnbaum, H., Bromet, E., Hwang, I., Sampson, N., & Shahly, V. (2010) · Psychological Medicine · doi:10.1017/s0033291709990213 · Cited by 542
Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis
Conrad, C. D. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.6.395 · Cited by 425
HPA axis and aging in depression: Systematic review and meta-analysis
Belvederi Murri, M., Pariante, C., Mondelli, V., Masotti, M., Atti, A. R., Mellacqua, Z., Antonioli, M., Ghio, L., Menchetti, M., Zanetidou, S., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.004 · Cited by 367
Metadata
- Authors
- Bremmer, M. A., Deeg, D. J. H., Beekman, A. T. F., Penninx, B. W. J. H., Lips, P., & Hoogendijk, W. J. G.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 62
- Issue
- 5
- Pages
- 479-486
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2006523438
- Cited by
- 200
- References
- 12
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- Bremmer, M. A., Deeg, D. J. H., Beekman, A. T. F., Penninx, B. W. J. H., Lips, P., & Hoogendijk, W. J. G. (2007). Major Depression in Late Life Is Associated with Both Hypo- and Hypercortisolemia. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2006.11.033
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