The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects
Abstract
OBJECTIVE: This study was done to compare the effects of 6-week treatment with amitriptyline on hypothalamic-pituitary-adrenocortical (HPA) regulation in elderly depressed patients and age-matched comparison subjects. METHOD: A combined dexamethasone-suppression/CRH-stimulation (dexamethasone/CRH) test was administered before initiation of amitriptyline treatment and at the end of weeks 1, 3, and 6 of treatment. Thirty-nine depressed inpatients, mean age = 69 years, completed the study. Fourteen normal volunteers, mean age = 67 years, served as comparison subjects. RESULTS: In relation to the comparison subjects, the depressed patients had a profoundly abnormal HPA response, in particular an exaggerated cortisol release in the dexamethasone/CRH test. This abnormality began to disappear after 1 week of treatment with amitriptyline. In contrast, amitriptyline did not affect neuroendocrine regulation in the comparison subjects at any time during the test period. CONCLUSIONS: The data suggest that amitriptyline affects HPA regulation in hypercortisolemic depression only, and they raise the possibility that normalization of its feedback control is related to the antidepressive effect of amitriptyline.
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The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders
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Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims
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Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1996-01-01
- Volume
- 153
- Issue
- 1
- Pages
- 93-99
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1840450113
- Cited by
- 275
- References
- 21
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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