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Cited by 289Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 109 of the 111 references it cites were found in a registry or an index.

Atomoxetine Improved Response Inhibition in Adults with Attention Deficit/Hyperactivity Disorder

Chamberlain, Samuel R., del Campo, Natalia, Dowson, Jonathan, Müller, Ulrich, Clark, Luke, Robbins, Trevor W., Sahakian, Barbara J.·2007·Biological Psychiatry
DOI 10.1016/j.biopsych.2007.03.003
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Abstract

Background Atomoxetine, a highly selective noradrenaline reuptake inhibitor (SNRI), shows efficacy in the treatment of attention-deficit/hyperactivity disorder (ADHD). Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD. Methods Twenty-two adults with DSM-IV ADHD were administered a single oral dose of atomoxetine (60 mg) in a placebo-controlled double-blind crossover design. Cognitive effects were assessed using stop-signal, sustained attention, spatial working memory, and set-shifting paradigms. Normative cognitive data from 20 healthy volunteers were collected for comparison. Results The ADHD patients under placebo conditions showed response inhibition and working memory deficits compared with healthy volunteers. Atomoxetine treatment in the ADHD patients was associated with shorter stop-signal reaction times and lower numbers of commission errors on the sustained attention task. Conclusions Atomoxetine improved inhibitory control, most likely via noradrenergically mediated augmentation of prefrontal cortex function. These results have implications for understanding the mechanisms by which atomoxetine exerts beneficial clinical effects and suggest novel treatment directions for other disorders of impulsivity.

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  1. Robinson, 2006, Effects of atomoxetine on inhibitory control in the rat stop-signal task, J Psychopharmacol, 20, A67

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Metadata

Authors
Chamberlain, S. R., del Campo, N., Dowson, J., Müller, U., Clark, L., Robbins, T. W., & Sahakian, B. J.
Affiliations
  • University of Cambridge (GB)
  • Utrecht University (NL)
Corresponding author
Chamberlain, Samuel R.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2007-11
Volume
62
Issue
9
Pages
977-984
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2007.03.003
OpenAlex
W2005105013
Cited by
288
References
111
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 8 · 2017: 15 · 2016: 17 · 2015: 13 · 2014: 27 · 2013: 27 · 2012: 30
FWCI
12.11
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
Funders
Wellcome Trust (076274/Z04/Z)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
atomoxetine, attention deficit hyperactivity disorder, adults, response inhibition, inhibitory control, norepinephrine reuptake inhibitors, single-dose pharmacokinetics, stop-signal task, sustained attention, spatial working memory, set-shifting, prefrontal cortex, impulsivity, cognitive effects
MeSH terms
Atomoxetine Hydrochloride, Administration, Oral, Adult, Analysis of Variance, Attention, Attention Deficit Disorder with Hyperactivity, Cognition, Double-Blind Method, Female, Humans, Inhibition, Psychological, Male, Memory, Short-Term, Neuropsychological Tests, Propylamines, Reaction Time, Time Factors, Case-Control Studies, Cross-Over Studies, Adrenergic Uptake Inhibitors

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