Cited by 289Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

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Atomoxetine Improved Response Inhibition in Adults with Attention Deficit/Hyperactivity Disorder

Chamberlain, Samuel R., del Campo, Natalia, Dowson, Jonathan, Müller, Ulrich, Clark, Luke, Robbins, Trevor W., Sahakian, Barbara J.·2007·Biological Psychiatry

DOI 10.1016/j.biopsych.2007.03.003

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Abstract

Background Atomoxetine, a highly selective noradrenaline reuptake inhibitor (SNRI), shows efficacy in the treatment of attention-deficit/hyperactivity disorder (ADHD). Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD. Methods Twenty-two adults with DSM-IV ADHD were administered a single oral dose of atomoxetine (60 mg) in a placebo-controlled double-blind crossover design. Cognitive effects were assessed using stop-signal, sustained attention, spatial working memory, and set-shifting paradigms. Normative cognitive data from 20 healthy volunteers were collected for comparison. Results The ADHD patients under placebo conditions showed response inhibition and working memory deficits compared with healthy volunteers. Atomoxetine treatment in the ADHD patients was associated with shorter stop-signal reaction times and lower numbers of commission errors on the sustained attention task. Conclusions Atomoxetine improved inhibitory control, most likely via noradrenergically mediated augmentation of prefrontal cortex function. These results have implications for understanding the mechanisms by which atomoxetine exerts beneficial clinical effects and suggest novel treatment directions for other disorders of impulsivity.

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Authors: Chamberlain, S. R., del Campo, N., Dowson, J., Müller, U., Clark, L., Robbins, T. W., & Sahakian, B. J.
Affiliations: University of Cambridge (GB)
Utrecht University (NL)
Corresponding author: Chamberlain, Samuel R.
ORCID: Chamberlain, Samuel R.
del Campo, Natalia
Müller, Ulrich
Clark, Luke
Robbins, Trevor W.
Sahakian, Barbara J.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2007-11
Volume: 62
Issue: 9
Pages: 977-984
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2007.03.003
OpenAlex: W2005105013
Cited by: 288
References: 111
Citations by year: 2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 8 · 2017: 15 · 2016: 17 · 2015: 13 · 2014: 27 · 2013: 27 · 2012: 30
FWCI: 12.11
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Funders: Wellcome Trust (076274/Z04/Z)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: atomoxetine, attention deficit hyperactivity disorder, adults, response inhibition, inhibitory control, norepinephrine reuptake inhibitors, single-dose pharmacokinetics, stop-signal task, sustained attention, spatial working memory, set-shifting, prefrontal cortex, impulsivity, cognitive effects
MeSH terms: Atomoxetine Hydrochloride, Administration, Oral, Adult, Analysis of Variance, Attention, Attention Deficit Disorder with Hyperactivity, Cognition, Double-Blind Method, Female, Humans, Inhibition, Psychological, Male, Memory, Short-Term, Neuropsychological Tests, Propylamines, Reaction Time, Time Factors, Case-Control Studies, Cross-Over Studies, Adrenergic Uptake Inhibitors

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Atomoxetine Improved Response Inhibition in Adults with Attention Deficit/Hyperactivity Disorder

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