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Atomoxetine Improved Response Inhibition in Adults with Attention Deficit/Hyperactivity Disorder
Abstract
Background Atomoxetine, a highly selective noradrenaline reuptake inhibitor (SNRI), shows efficacy in the treatment of attention-deficit/hyperactivity disorder (ADHD). Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD. Methods Twenty-two adults with DSM-IV ADHD were administered a single oral dose of atomoxetine (60 mg) in a placebo-controlled double-blind crossover design. Cognitive effects were assessed using stop-signal, sustained attention, spatial working memory, and set-shifting paradigms. Normative cognitive data from 20 healthy volunteers were collected for comparison. Results The ADHD patients under placebo conditions showed response inhibition and working memory deficits compared with healthy volunteers. Atomoxetine treatment in the ADHD patients was associated with shorter stop-signal reaction times and lower numbers of commission errors on the sustained attention task. Conclusions Atomoxetine improved inhibitory control, most likely via noradrenergically mediated augmentation of prefrontal cortex function. These results have implications for understanding the mechanisms by which atomoxetine exerts beneficial clinical effects and suggest novel treatment directions for other disorders of impulsivity.
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“In humans, both normal subjects (Chamberlain et al., 2006), and patients with ADHD (Chamberlain et al., 2007) show improved PFC inhibition of behavior following atomoxetine, consistent with the animal data.”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Chamberlain et al., 2007
In the citing paper
“Atomoxetine improves measures of PFC cognitive function in rats (Newman et al., 2008; Robinson et al., 2008; Seu et al., 2009), monkeys (Gamo et al., 2010; Seu et al., 2009), and humans (Chamberlain et al., 2007; Chamberlain et al., 2006).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Chamberlain et al., 2007
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Metadata
- Authors
- Chamberlain, S. R., del Campo, N., Dowson, J., Müller, U., Clark, L., Robbins, T. W., & Sahakian, B. J.
- Affiliations
- University of Cambridge (GB)
- Utrecht University (NL)
- Corresponding author
- Chamberlain, Samuel R.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 62
- Issue
- 9
- Pages
- 977-984
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2005105013
- Cited by
- 288
- References
- 111
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 8 · 2017: 15 · 2016: 17 · 2015: 13 · 2014: 27 · 2013: 27 · 2012: 30
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- Wellcome Trust (076274/Z04/Z)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- atomoxetine, attention deficit hyperactivity disorder, adults, response inhibition, inhibitory control, norepinephrine reuptake inhibitors, single-dose pharmacokinetics, stop-signal task, sustained attention, spatial working memory, set-shifting, prefrontal cortex, impulsivity, cognitive effects
- MeSH terms
- Atomoxetine Hydrochloride, Administration, Oral, Adult, Analysis of Variance, Attention, Attention Deficit Disorder with Hyperactivity, Cognition, Double-Blind Method, Female, Humans, Inhibition, Psychological, Male, Memory, Short-Term, Neuropsychological Tests, Propylamines, Reaction Time, Time Factors, Case-Control Studies, Cross-Over Studies, Adrenergic Uptake Inhibitors
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