Cited by 510Memory and Neural MechanismsPosttraumatic Stress Disorder ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.

A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy

Norberg, Melissa M., Krystal, John H., Tolin, David F.·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2008.01.012

Open this paper in CoChat — free account

Abstract

Background Translational research suggests that D-cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist, might facilitate fear extinction and exposure therapy by either enhancing NMDA receptor function during extinction or by reducing NMDA receptor function during fear memory consolidation. This article provides a quantitative review of DCS-augmented fear extinction and exposure therapy literature.Methods English-language journal articles that examined DCS augmented with fear extinction or exposure therapy were identified through public databases from June 1998 through September 2007, through references of originally identified articles and contact with DCS investigators. Data were extracted for study author, title, and year; trial design; type of subject (animal vs. human; clinical vs. nonclinical); sample size, DCS dose, and timing in relation to extinction/exposure procedures; dependent variable; group means and SDs at post-extinction/exposure; and follow-up outcome.Results D-cycloserine enhances fear extinction/exposure therapy in both animals and anxiety-disordered humans. Gains generally were maintained at follow-up, although some lessening of efficacy was noted. D-cycloserine was more effective when administered a limited number of times and when given immediately before or after extinction training/exposure therapy.Conclusions This meta-analysis suggests that DCS is a useful target for translational research on augmenting exposure-based treatment via compounds that impact neuroplasticity. D-cycloserine 's major contribution to exposure-based therapy might be to increase its speed or efficiency, because the effects of DCS seem to decrease over repeated sessions. This information might guide translational researchers in discovering more selective and/or effective agents that effectively enhance (or reduce) NMDA receptor function.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2008.01.012

Cites

121 of 121 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712
Meta-Analytic Procedures for Social Research
Rosenthal, R. (1991) · doi:10.4135/9781412984997 · Cited by 4,635
Meta-Analytic Procedures for Social Research.
Metcalfe, A., & Rosenthal, R. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348600 · Cited by 4,249
Meta-analysis in social research
(1982) · Evaluation and Program Planning · doi:10.1016/0149-7189(82)90011-8 · Cited by 3,896
Development and validation of measures of social phobia scrutiny fear and social interaction anxiety11Editor’s note: This article was written before the development of some contemporary measures of social phobia, such as the Social Phobia and Anxiety Inventory (Turner et al., 1989). We have invited this article for publication because of the growing interest in the scales described therein. S.T.
Mattick, R. P., & Clarke, J. C. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10031-6 · Cited by 3,367
The practice of behavior therapy
Wolpe, J. (1969) · Cited by 2,343
The Yale-Brown Obsessive-Compulsive Scale: measures of internal consistency.
Kim, S.-W., Dysken, M., Pheley, A., & Hoover, K. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90039-6 · Cited by 2,333
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793

Show all 121 references

Research works printed but not linked: 1

Ledgerwood, 2004, D-cycloserine and the facilitation of extinction of conditioned fear: Consequences for reinstatement, Behav Neurosci, 118, 505, 10.1037/0735-7044.118.3.505 · DOI

Sorted by citations

Items 301–400 of 509

Extinction learning of stimulus reward contingencies: The acute effects of alcohol
Loeber, S., & Duka, T. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.01.014 · Cited by 15
Glucocorticoid- β-adrenoceptors interactions in the infralimbic cortex in acquisition and consolidation of auditory fear memory extinction in rats
Meamar, M., Rashidy‐Pour, A., Rahmani, M., Vafaei, A. A., & Raise‐Abdullahi, P. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173560 · Cited by 14
Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish
Lima, M. G., Silva, S. D. N. D. S., Silva, R. X. D. C., Oliveira, K. R. H. M., Batista, E. D. J. O., Maximino, C., & Herculano, A. M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.08.005 · Cited by 13
Future perspectives in psychotherapy
Schnyder, U. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0051-z · Cited by 11
A randomized controlled trial of cognitive remediation and d-cycloserine for individuals with bipolar disorder
Breitborde, N. J. K., Dawson, S. C., Woolverton, C. B., Dawley, D., Bell, E. K., Norman, K. R., Polsinelli, A. J., Bernstein, B., Mirsky, P., Pletkova, C., et al. (2014) · BMC Psychology · doi:10.1186/s40359-014-0041-4 · Cited by 16
Psychotherapeutische und medikamentöse Behandlung der kindlichen Zwangsstörung
Vloet, T. D., Simons, M., & Herpertz‐Dahlmann, B. (2011) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000147 · Cited by 13
Affect Labeling to Facilitate Inhibitory Learning: Clinical Considerations
Marks, E. H., Walker, R. S. W., Ojalehto, H. J., Bedard‐Gilligan, M. A., & Zoellner, L. A. (2018) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2018.05.001 · Cited by 14
Learn to forget: Does post-exposure administration of d-cycloserine enhance fear extinction in agoraphobia?
Pyrkosch, L., Mumm, J., Alt, I., Fehm, L., Fydrich, T., Plag, J., & Ströhle, A. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.016 · Cited by 14
Glutamatergic Contribution to Probabilistic Reasoning and Jumping to Conclusions in Schizophrenia: A Double-Blind, Randomized Experimental Trial
Strube, W., Marshall, L., Quattrocchi, G., Little, S. J., Cimpianu, C.-L., Ulbrich, M., Schneider-Axmann, T., Falkai, P., Hasan, A., & Bestmann, S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.03.018 · Cited by 15
The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
Masella, G., Silva, F. J. D. C., Corti, E., Azkona, G., Madeira, M. F., Tomé, Â. R., Ferreira, S. G., Cunha, R. A., Duarte, C. B., & Santos, M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02412-z · Cited by 13
d-Cycloserine acts via increasing the GluN1 protein expressions in the frontal cortex and decreases the avoidance and risk assessment behaviors in a rat traumatic stress model
Sarıdoğan, G. E., Aykaç, A., Cabadak, H., Cerit, C., Çalışkan, M., & Gören, M. Z. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.050 · Cited by 13
Inhibition of glycine transporter-1 reduces cue-induced nicotine-seeking, but does not promote extinction of conditioned nicotine cue responding in the rat
Cervo, L., Clemente, A. D., Orrù, A., Moro, F., Cassina, C., Pich, E. M., Corsi, M., Gozzi, A., & Bifone, A. (2013) · Addiction Biology · doi:10.1111/adb.12049 · Cited by 13
A Novel Treatment for Tinnitus and Tinnitus-Related Cognitive Difficulties Using Computer-Based Cognitive Training and D-Cycloserine
Krings, J. G., Wineland, A., Kallogjeri, D., Rodebaugh, T. L., Nicklaus, J. E., Lenze, E. J., & Piccirillo, J. F. (2014) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2014.2669 · Cited by 14
Microendophenotypes of Psychiatric Disorders: Phenotypes of Psychiatric Disorders at the Level of Molecular Dynamics, Synapses, Neurons, and Neural Circuits
Kida, S., & Kato, T. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303002128 · Cited by 13
The Future of D-Cycloserine and Other Cognitive Modifiers in Obsessive- Compulsive and Related Disorders
Sulkowski, M. L., GELLER, D. A., Lewin, A. B., Murphy, T. K., Andrew Mittelman, B., A., B., Brown, A., A., B., & Storch, E. (2014) · Current Psychiatry Reviews · doi:10.2174/1573400510666140619224942 · Cited by 11
A large QTL for fear and anxiety mapped using an F2 cross can be dissected into multiple smaller QTLs
Parker, C. C., Sokoloff, G., Leung, E., Kirkpatrick, S. L., & Palmer, A. A. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12064 · Cited by 12
d-Cycloserine does not enhance the effects of in vivo exposure among young people with broad-based anxiety disorders
Rapee, R. M., Jones, M. P., Hudson, J. L., Malhi, G. S., Lyneham, H. J., & Schneider, S. C. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.10.004 · Cited by 14
Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site
Lench, A. M., Robson, E., & Jones, R. S. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133548 · Cited by 12
Prevention of recurrent affective episodes using extinction training in the reconsolidation window: A testable psychotherapeutic strategy
Post, R. M., & Kegan, R. G. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.01.034 · Cited by 13
Glutamatergic Approaches to the Conceptualization and Treatment of Schizophrenia
Kantrowitz, J. T., & Javitt, D. C. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_3 · Cited by 12
Executive Dysfunction in Addiction
Jarmolowicz, D. P., Mueller, E. T., Koffarnus, M. N., Carter, A. E., Gatchalian, K. M., & Bickel, W. K. (2013) · Wiley eBooks · doi:10.1002/9781118384404.ch2 · Cited by 12
Hypochondriasis and Health‐Related Anxiety
Taylor, S. J., McKay, D., & Abramowitz, J. S. (2012) · Wiley eBooks · doi:10.1002/9781118156391.ebcp002026 · Cited by 13
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives
Dhiman, A., Mehan, S., Khan, Z., Tiwari, A., Gupta, G. D., & Narula, A. S. (2024) · Current Gene Therapy · doi:10.2174/0115665232316708240828063527 · Cited by 11
Inter-individual differences in trait negative affect moderate cortisol's effects on memory formation: Preliminary findings from two studies
Abercrombie, H. C., Wirth, M. M., & Hoks, R. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.014 · Cited by 11
Effects of short‐term cognitive‐coping therapy on resting‐state brain function in obsessive‐compulsive disorder
Ma, J., Wang, C., Huang, P. C., Wang, X., Shi, L.-J., Li, H., Sang, D., Kou, S., Li, Z., Zhao, H., et al. (2021) · Brain and Behavior · doi:10.1002/brb3.2059 · Cited by 11
The Future and Promise of Cognitive Behavioral Therapy: A Commentary
Zinbarg, R. E., Mashal, N. M., Black, D. A., & Flückiger, C. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.04.003 · Cited by 11
The NMDA receptor partial agonist d-cycloserine does not enhance motor learning
Günthner, J., Scholl, J., Favaron, E., Harmer, C. J., Johansen‐Berg, H., & Reinecke, A. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116658988 · Cited by 11
N-methyl-d-aspartate Partial Agonist Enhanced Intensive Cognitive-Behavioral Therapy of Panic Disorder in Adolescents
Leyfer, O. T., Carpenter, A. L., & Pincus, D. B. (2018) · Child Psychiatry & Human Development · doi:10.1007/s10578-018-0837-1 · Cited by 11
An Examination of Harm Beliefs in Dog Fearful Children
Byrne, S., Rapee, R. M., Malhi, G. S., Sweller, N., & Hudson, J. L. (2016) · Journal of Experimental Psychopathology · doi:10.5127/jep.048015 · Cited by 10
Evidence-Based Pharmacotherapy for Pediatric Obsessive-Compulsive Disorder and Chronic Tic Disorders
Nadai, A. S. D., Storch, E. A., Mcguire, J. F., Lewin, A. B., & Murphy, T. K. (2011) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s6616 · Cited by 10
Simple and efficient synthetic routes to d-cycloserine
Kim, H., & Park, K. J. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.01.089 · Cited by 11
Do Glutamatergic Agents Represent a New Class of Antidepressant Drugs? Part 2
Sanacora, G. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09ac05757blu · Cited by 10
Maintaining Clinical Relevance: Considerations for the Future of Research into D-Cycloserine and Cue Exposure Therapy for Addiction
Das, R., & Kamboj, S. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.030 · Cited by 10
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) 2025 international guidelines for the management of patients with obsessive-compulsive disorder
Ameringen, M. V., Fineberg, N. A., Ravindran, A. V., Arnold, P. D., Beaulieu, S., Brakoulias, V., Brietzke, E. M., Dowlati, Y., Drummond, L. M., Ferretti, C. J., et al. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.12.039 · Cited by 12
Comparison of patient-reported distress during harm avoidance and incompleteness exposure tasks for youth with OCD
Milgram, L., Sheehan, K. G., Cain, G. H., Carper, M. M., O’Connor, E., Freeman, J. B., Garcia, A. M., Case, B. G., & Benito, K. (2022) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2022.100760 · Cited by 9
Effects of d -cycloserine on individual differences in relapse of fear
King, G., Graham, B. M., & Richardson, R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.02.005 · Cited by 9
Combining d-cycloserine and exposure-based CBT for the anxiety disorders.
Deveney, C. M., McHugh, R. K., Tolin, D. F., Pollack, M. H., & Otto, M. W. (2009) · Cited by 9
Self-citation
Novel pharmacological agents targeting memory and cognition in the treatment of anxiety disorders
Nandhra, H. S., Murphy, C. L., & Sule, A. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2348 · Cited by 9
Anxiety Disorders in Women
Merikangas, K. R., Burstein, M., & Schmitz, A. P. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384978-6.00084-4 · Cited by 11
Updates on Pharmacological Treatment of Post-Traumatic Stress Disorder
Koirala, R., Søegaard, E. G. I., & Thapa, S. B. (2017) · Journal of Nepal Medical Association · doi:10.31729/jnma.3108 · Cited by 9
Pharmacological Treatment of Anxiety Disorders in Children and Adolescents
Birmaher, B. B., & Sakolsky, D. J. (2012) · Wiley eBooks · doi:10.1002/9781118315088.ch11 · Cited by 9
Embracing Internal States: A Review of Optimization of Repetitive Transcranial Magnetic Stimulation for Treating Depression
Wu, T., Yu, Q., Zhu, X., Li, Y., Zhang, M., Deng, J., & Lü, L. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-024-01347-3 · Cited by 11
Enhancing Prolonged Exposure Therapy for Posttraumatic Stress Disorder with D-Cycloserine: Further Support for Treatments That Promote Experience-Dependent Neuroplasticity
Krystal, J. H. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.031 · Cited by 8
Self-citation
Anxioselective profile of glycineB receptor partial agonist, d-cycloserine, in plus-maze-naïve but not plus-maze-experienced mice
Rodgers, R. J., Howard, K., Stewart, S., Waring, P., & Wright, F. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.08.005 · Cited by 8
Optimizing the efficacy of exposure in PTSD treatment
Hendriks, G., de Kleine, R. A., & van Minnen, A. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.27628 · Cited by 8
Fear-Related Anxiety Disorders and Post-Traumatic Stress Disorder
Vahabzadeh, A. B. N., Gillespie, C. F., & Ressler, K. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-398270-4.00037-9 · Cited by 8
Extinction of conditioned opiate withdrawal in rats is blocked by intracerebroventricular infusion of an NMDA receptor antagonist
Coleman, B. R., Carlezon, W. A., & Myers, K. M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.01.049 · Cited by 7
Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke
Butler, A. J., Kallos, J. A., Housley, S. N., LaPlaca, M. C., Traynelis, S. F., & Wolf, S. L. (2015) · Rehabilitation Research and Practice · doi:10.1155/2015/534239 · Cited by 7
D-cycloserine augmentation of cognitive behavioral therapy for delusions: A randomized clinical trial
Diminich, E. D., Dickerson, F., Bello, I., Cather, C., Kingdon, D., Rouhakhtar, P. R., Hart, K. L., Li, C., Troxel, A. B., & GOFF, D. C. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.06.015 · Cited by 7
Evidence-Based Treatments in Treatment-Naïve and Treatment-Resistant Pediatric Obsessive-Compulsive Disorder
Skarphéðinsson, G., & Ivarsson, T. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0047-0 · Cited by 8
Cognitive Processes in Cognitive and Pharmacological Therapies
Tryon, W. W. (2009) · Cognitive Therapy and Research · doi:10.1007/s10608-009-9243-0 · Cited by 7
Harnessing N-Methyl- d -Aspartate Receptors for New Treatment Development in Psychiatry: Positive Lessons From Negative Studies
Javitt, D. C. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13040503 · Cited by 7
Specific Phobias
Cowart, M. J. W., & Ollendick, T. H. (2012) · doi:10.1002/9781118315088.ch16 · Cited by 7
Grant Report on D-Serine Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia †
de la Garrigue, N., Glasser, J., Sehatpour, P., Iosifescu, D. V., Dias, E. C., Carlson, M., Shope, C. B., Sobeih, T. M., Choo, T. H., Wall, M. M., et al. (2020) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20200018 · Cited by 6
Treatment of disgust in specific emotional disorders
Rast, C. E., Woronko, S. E., Jessup, S. C., & Olatunji, B. O. (2023) · Bulletin of the Menninger Clinic · doi:10.1521/bumc.2023.87.suppa.5 · Cited by 8
A New Appraisal of Combined Treatments for PTSD in the Era of Psychotherapy Adjunctive Medications
Sheerin, C. M., Seim, R. W., & Spates, C. R. (2011) · Journal of Contemporary Psychotherapy · doi:10.1007/s10879-011-9195-z · Cited by 6
D-Cycloserine Augmented Treatment of Anxiety Disorders in Children and Adolescents: A Review of Preliminary Research
Byrne, S., Farrell, L. J., Storch, E. A., & Rapee, R. M. (2014) · Psychopathology Review · doi:10.5127/pr.033013 · Cited by 6
Expanding Findings on D-Cycloserine Augmentation of Therapeutic Learning: A Role for Social Learning Relative to Autism Spectrum Disorders?
Otto, M. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.005 · Cited by 6
Treatment of Psychiatric Comorbidities in Tourette Syndromes
Cardona, F., & Rizzo, R. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796267.003.0025 · Cited by 6
Dissociation in the effects of stress and D1 receptors activation on basolateral amygdalar LTP in juvenile and adult animals
Schayek, R., & Maroun, M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.11.005 · Cited by 6
Spatial memory and hippocampal enhancement
Peters, M., Muñoz, M., & Morris, R. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.03.005 · Cited by 6
Treatments for childhood anxiety disorders: integrating physiological and psychosocial interventions
Rapee, R. M. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.85 · Cited by 6
Pharmacological enhancement of fear extinction
Davis, B., Rosenberg, B. M., Kearney, M. G., Treanor, M., Craske, M. G., & Barry, T. J. (2025) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2025.06.011 · Cited by 5
Memantine and Riluzole Exacerbate, Rather Than Ameliorate Behavioral Deficits Induced by 8-OH-DPAT Sensitization in a Spatial Task
Janikova, M., Mainerová, K., Vojtěchová, I., Petrásek, T., Svoboda, J., & Stuchlı́k, A. (2021) · Biomolecules · doi:10.3390/biom11071007 · Cited by 5
Modeling cue-exposure therapy for alcohol use disorder in rhesus monkeys: Effects of putative cognitive enhancers
Pareek, T., Overton, J. S., Nguyen, L. T., Rahman, M. T., Sharmin, D., Cook, J. M., & Platt, D. M. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109735 · Cited by 5
The effect of d-cycloserine on brain processing of breathlessness over pulmonary rehabilitation: an experimental medicine study
Finnegan, S., Harrison, O. K., Booth, S., Dennis, A., Ezra, M., Harmer, C. J., Herigstad, M., Guillaume, B., Nichols, T. E., Rahman, N. M., et al. (2023) · ERJ Open Research · doi:10.1183/23120541.00479-2022 · Cited by 5
Dose-Dependent Beneficial Effect of Ketone Supplement-Evoked Ketosis on Anxiety Level in Female WAG/Rij Rats: Sometimes Less Is More
Rauch, E., Ari, C., & Kovács, Z. (2023) · Nutrients · doi:10.3390/nu15204412 · Cited by 5
Effects of ketamine on fear memory extinction: a review of preclinical literature
Boese, M., Berman, R. Y., Radford, K. D., Johnson, L. R., & Choi, K.-H. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1546460 · Cited by 5
Cold Pressor “Augmentation” Does Not Differentially Improve Treatment Response for Spider Phobia
Schmidt, N. B., Richey, J. A., Funk, A. P., & Mitchell, M. A. (2010) · Cognitive Therapy and Research · doi:10.1007/s10608-010-9310-6 · Cited by 5
Effects of D-cycloserine augmentation on cognitive behavioral therapy in patients with obsessive-compulsive disorder: A systematic review and meta-analysis
Gu, W., Storch, E. A., Zhao, Q., Xu, T., & Wang, Z. (2017) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2017.03.001 · Cited by 5
Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation
Maeng, L. Y., Rosenfeld, D., Simandl, G. J., Koehler, F., Senko, A. W., Moon, J., Varnavides, G., Murillo, M. F., Reimer, A. E., Wald, A., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.901108 · Cited by 6
D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report
Norberg, M. M., Gilliam, C. M., Villavicencio, A. L., Pearlson, G. D., & Tolin, D. F. (2011) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2011.05.002 · Cited by 6
Self-citation
Does d-cycloserine facilitate the effects of homework compliance on social anxiety symptom reduction?
Roque, A. D., Rosenfield, D., Smits, J. A. J., Simon, N. M., Otto, M. W., Marques, L. M., Pollack, M. H., Hofmann, S. G., & Meuret, A. E. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2017.11.004 · Cited by 5
Evolutionary Perspective on Improving Mental Health
Grinde, B. (2022) · Encyclopedia · doi:10.3390/encyclopedia2030099 · Cited by 4
Personalizing Brain Stimulation for Psychiatric Disorders: From Circuits to Closed-Loop Control.
Cline, C., & Keller, C. (2026) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20251327 · Cited by 6
Grin2b -mutant mice exhibit heightened remote fear via suppressed extinction and chronic amygdalar synaptic and neuronal dysfunction
Kang, M., Kim, S., Shin, W., Kim, K., Jung, Y., Choi, W., Paik, S., & Kim, E. (2025) · Science Advances · doi:10.1126/sciadv.adr7691 · Cited by 4
Cognitive Enhancers in Exposure Therapy for Anxiety and Related Disorders
Hofmann, S. G., Gutner, C. A., & Asnaani, A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3342-2_6 · Cited by 3
Generalization of exposure therapy: Systematic review and recommendations for future research
Kodzaga, I., Heistermann, J., & Zlomuzica, A. (2025) · Behaviour Research and Therapy · doi:10.1016/j.brat.2025.104751 · Cited by 4
Synergistic behavioral and neuroplastic effects of psilocybin-NMDAR modulator administration
Tal, T. B., Pogodin, I., Botvinnik, A., Lifschytz, T., Heresco‐Levy, U., & Lerer, B. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03428-x · Cited by 4
Pre-treatment hippocampal functioning impacts context renewal for cholinergic modulated exposure therapy
Sewart, A. R., McGlade, A. L., Treanor, M., Fanselow, M. S., & Craske, M. G. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108167 · Cited by 4
Recent Developments in the Assessment and Treatment of Pediatric Obsessive-Compulsive Disorder
Berman, N. C., & Abramowitz, J. S. (2010) · Child & Youth Care Forum · doi:10.1007/s10566-010-9096-4 · Cited by 4
Combined Cognitive Behavioral and Pharmacologic Treatment Strategies: Current Status and Future Directions
Smits, J. A. J., Reese, H. E., Powers, M. B., & Otto, M. W. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0612-0_5 · Cited by 4
The Biology and Efficacy of Combination Strategies for Anxiety Disorders
Ganasen, K. A., & Stein, D. J. (2012) · Wiley eBooks · doi:10.1002/9781119945901.ch1 · Cited by 4
Exposure Therapy
Treanor, M., & Craske, M. G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397045-9.00024-0 · Cited by 5
New and emerging treatments for anxiety disorders
Zbozinek, T. D., Khalsa, S. S., & Craske, M. G. (2026) · BMJ · doi:10.1136/bmj-2024-083441 · Cited by 4
The potential effect of d-cycloserine on the development of anxiety during exposure sessions in patients with agoraphobia
Pyrkosch, L., Lautenbacher, L. M., Mumm, J., Plag, J., Fehm, L., Fydrich, T., & Ströhle, A. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.10.018 · Cited by 3
Response to the Commentaries
Watt, D. F., & Panksepp, J. (2009) · Neuropsychoanalysis · doi:10.1080/15294145.2009.10773601 · Cited by 3
Learned fear and innate anxiety in rodents and their relevance to human anxiety disorders
Gordon, J. A., & Adhikari, A. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777578.018 · Cited by 2
Alcohol Use and Alcohol Use Disorders
Sher, K. J., Martinez, J. A., & Littlefield, A. K. (2014) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199328710.013.004 · Cited by 2
AMPA receptor potentiation alleviates NLRP3 knockout-induced fear generalization in mice
Li, W., Gong, Q., Zhu, W., Ali, T., Yu, Z.-J., Li, S., & Yu, X. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150074 · Cited by 3
Medication Management of Childhood OCD
Ivarsson, T., Skarphéðinsson, G., & Weidle, B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811427-8.00009-5 · Cited by 3
Anxiety and its disorders: Implications for pharmacotherapy.
Abramowitz, J. S., & Deacon, B. J. (2010) · Clinical Psychology Science and Practice · doi:10.1111/j.1468-2850.2010.01199.x · Cited by 3
Fear Conditioning and Extinction as a Model of PTSD in Mice
Gafford, G. M., & Ressler, K. J. (2011) · Neuromethods · doi:10.1007/978-1-61779-313-4_11 · Cited by 3
The effect of d-cycloserine on social anxiety treatment using a behavioral outcome measure and a postsession administration strategy.
Sheerin, C. M., Kozak, A. T., Hale, A. C., Ramesh, B. K., & Spates, C. R. (2016) · Behavior Analysis Research and Practice · doi:10.1037/bar0000054 · Cited by 3
The Efficacy of Augment of D-Cycloserine and Cognitive-behavioral Therapy on Adolescent with one Type of Anxiety Disorders: A Double-blind Randomized Controlled Trial
Arman, S., Soheilimehr, A., & Maracy, M. R. (2017) · Advanced Biomedical Research · doi:10.4103/2277-9175.200786 · Cited by 5
Paediatric OCD: Developmental Aspects and Treatment Considerations
GELLER, D. A., Faro, A. L., Brown, A. R., & Levy, H. C. (2012) · Wiley eBooks · doi:10.1002/9781119941125.ch7 · Cited by 4
Cognitive Enhancers as Adjuncts to Exposure‐based Treatments
Vervliet, B., & Vervoort, E. (2014) · Wiley eBooks · doi:10.1002/9781118775349.ch65 · Cited by 2
Anxiety
Otto, M. W., Calkins, A. W., & Hearon, B. A. (2010) · The Corsini Encyclopedia of Psychology · doi:10.1002/9780470479216.corpsy0073 · Cited by 3
Slope of Change through D-Cycloserine Facilitation of Exposure Therapy in a Social Anxiety Population
Sheerin, C. M. (2013) · ScholarWorks - WMU (Western Michigan University) · Cited by 3
Novel approaches in treatment of pediatric anxiety
Park, J. M., & Geller, D. A. (2014) · F1000Prime Reports · doi:10.12703/p6-30 · Cited by 2

Authors: Norberg, M. M., Krystal, J. H., & Tolin, D. F.
Affiliations: Yale University (US)
Corresponding author: Tolin, David F.
ORCID: Norberg, Melissa M.
Krystal, John H.
Tolin, David F.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-06
Volume: 63
Issue: 12
Pages: 1118-1126
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2008.01.012
OpenAlex: W2159630298
Cited by: 510
References: 121
Citations by year: 2026: 10 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 15 · 2021: 13 · 2020: 12 · 2019: 16 · 2018: 28 · 2017: 28 · 2016: 23 · 2015: 50 · 2014: 37 · 2013: 53 · 2012: 51
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: D-cycloserine, fear extinction, exposure therapy, NMDA receptor agonist, anxiety disorders, fear memory consolidation, neuroplasticity, augmentation therapy, translational research
MeSH terms: Animals, Anxiety Disorders, Combined Modality Therapy, Cycloserine, Desensitization, Psychologic, Extinction, Psychological, Fear, Humans, Implosive Therapy, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks