Cited by 510Memory and Neural MechanismsPosttraumatic Stress Disorder ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.

A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy

Norberg, Melissa M., Krystal, John H., Tolin, David F.·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2008.01.012

Open this paper in CoChat — free account

Abstract

Background Translational research suggests that D-cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist, might facilitate fear extinction and exposure therapy by either enhancing NMDA receptor function during extinction or by reducing NMDA receptor function during fear memory consolidation. This article provides a quantitative review of DCS-augmented fear extinction and exposure therapy literature.Methods English-language journal articles that examined DCS augmented with fear extinction or exposure therapy were identified through public databases from June 1998 through September 2007, through references of originally identified articles and contact with DCS investigators. Data were extracted for study author, title, and year; trial design; type of subject (animal vs. human; clinical vs. nonclinical); sample size, DCS dose, and timing in relation to extinction/exposure procedures; dependent variable; group means and SDs at post-extinction/exposure; and follow-up outcome.Results D-cycloserine enhances fear extinction/exposure therapy in both animals and anxiety-disordered humans. Gains generally were maintained at follow-up, although some lessening of efficacy was noted. D-cycloserine was more effective when administered a limited number of times and when given immediately before or after extinction training/exposure therapy.Conclusions This meta-analysis suggests that DCS is a useful target for translational research on augmenting exposure-based treatment via compounds that impact neuroplasticity. D-cycloserine 's major contribution to exposure-based therapy might be to increase its speed or efficiency, because the effects of DCS seem to decrease over repeated sessions. This information might guide translational researchers in discovering more selective and/or effective agents that effectively enhance (or reduce) NMDA receptor function.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2008.01.012

Cites

121 of 121 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712
Meta-Analytic Procedures for Social Research
Rosenthal, R. (1991) · doi:10.4135/9781412984997 · Cited by 4,635
Meta-Analytic Procedures for Social Research.
Metcalfe, A., & Rosenthal, R. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348600 · Cited by 4,249
Meta-analysis in social research
(1982) · Evaluation and Program Planning · doi:10.1016/0149-7189(82)90011-8 · Cited by 3,896
Development and validation of measures of social phobia scrutiny fear and social interaction anxiety11Editor’s note: This article was written before the development of some contemporary measures of social phobia, such as the Social Phobia and Anxiety Inventory (Turner et al., 1989). We have invited this article for publication because of the growing interest in the scales described therein. S.T.
Mattick, R. P., & Clarke, J. C. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10031-6 · Cited by 3,367
The practice of behavior therapy
Wolpe, J. (1969) · Cited by 2,343
The Yale-Brown Obsessive-Compulsive Scale: measures of internal consistency.
Kim, S.-W., Dysken, M., Pheley, A., & Hoover, K. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90039-6 · Cited by 2,333
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310
Energy on demand.
Magistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G. (1999) · Science · doi:10.1126/science.283.5401.496 · Cited by 1,170
Cognitive Enhancers as Adjuncts to Psychotherapy: Use of D-Cycloserine in Phobic Individuals to Facilitate Extinctionof Fear
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063
Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive–compulsive disorder
Foa, E. B., Liebowitz, M. R., Kozak, M. J., Davies, S., Campeas, R., Franklin, M. E., Huppert, J. D., Kjernisted, K., Rowan, V., Schmidt, A. B., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.151 · Cited by 1,048
Multicenter Collaborative Panic Disorder Severity Scale
Shear, M. K., Brown, T. A., Barlow, D. H., Money, R., Sholomskas, D. E., Woods, S. W., Gorman, J. M., & Papp, L. A. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1571 · Cited by 1,001
Psychometric properties of the Liebowitz Social Anxiety Scale
HEIMBERG, R. G., HORNER, K. J., JUSTER, H. R., SAFREN, S. A., BROWN, E. J., SCHNEIER, F. R., & LIEBOWITZ, M. R. (1999) · Psychological Medicine · doi:10.1017/s0033291798007879 · Cited by 968
Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia
Lahti, A., Koffel, B., Laporte, D., & Tamminga, C. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00131-i · Cited by 965
Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder: A Randomized Controlled Trial
Barlow, D. H., Gorman, J. M., Shear, M. K., & Woods, S. W. (2000) · JAMA · doi:10.1001/jama.283.19.2529 · Cited by 953
Why We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala
Fanselow, M. S., & LeDoux, J. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80775-8 · Cited by 933
Randomized trial of prolonged exposure for posttraumatic stress disorder with and without cognitive restructuring: outcome at academic and community clinics
Foa, E. B., Hembree, E. A., Cahill, S. P., Rauch, S. A. M., Riggs, D. S., Feeny, N. C., & Yadin, E. (2005) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.73.5.953 · Cited by 931
The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia
GOFF, D. C., & Coyle, J. T. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1367 · Cited by 926
Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats
Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815
D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia
Tsai, G. E., Yang, P., Chang, Y., & Chong, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.032 · Cited by 676
A comparison of cognitive therapy, applied relaxation and imipramine in the treatment of panic disorder
Clark, D. M., Salkovskis, P. M., Hackmann, A., Middleton, H., Anastasiades, P., & Gelder, M. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.164.6.759 · Cited by 673
Glycine and N-Methyl-d-Aspartate Receptors: Physiological Significance and Possible Therapeutic Applications
Danysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 652
Neural systems involved in fear and anxiety measured with fear-potentiated startle.
Davis, M. (2006) · American Psychologist · doi:10.1037/0003-066x.61.8.741 · Cited by 611
Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder
Hofmann, S. G., Meuret, A. E., Smits, J. A. J., Simon, N. M., Pollack, M. H., Eisenmenger, K., Shiekh, M., & Otto, M. W. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.298 · Cited by 560
Glycine transporters are differentially expressed among CNS cells
Zafra, F., Aragón, C., Olivares, L., Danbolt, N. C., Giménez, C., & Storm‐Mathisen, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03952.1995 · Cited by 521
Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work
Davis, M., Ressler, K., Rothbaum, B. O., & Richardson, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.084 · Cited by 498
Reconsolidation and Extinction of Conditioned Fear: Inhibition and Potentiation
Lee, J. L. C., Milton, A. L., & Everitt, B. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2466-06.2006 · Cited by 479
Alprazolam and Exposure Alone and Combined in Panic Disorder with Agoraphobia: A Controlled Study in London and Toronto
Marks, I. M., Swinson, R. P., Başoǧlu, M., Kuch, K., Noshirvani, H., O'Sullivan, G., Lelliott, P. T., Kirby, M., McNamee, G., Sengun, S., et al. (1993) · British Journal of Psychiatry · doi:10.1192/bjp.162.6.776 · Cited by 478
NMDA-dependent modulation of CA1 local circuit inhibition
Grunze, H., Rainnie, D., Hasselmo, M., Barkai, E., Hearn, E., McCarley, R., & Greene, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02034.1996 · Cited by 467
Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia
Coyle, J. T., Tsai, G. E., & GOFF, D. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.020 · Cited by 443
The glycine site of the NMDA receptor — five years on
Kemp, J. A., & Leeson, P. D. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90108-v · Cited by 437
A Placebo-Controlled Trial of D-Cycloserine Added to Conventional Neuroleptics in Patients With Schizophrenia
GOFF, D. C., Tsai, G. E., Levitt, J. J., AMICO, E. T., Manoach, D. S., Schoenfeld, D., Hayden, D. L., McCarley, R. W., & Coyle, J. T. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.1.21 · Cited by 436
Glycine binding primes NMDA receptor internalization
Nong, Y., Huang, Y., Ju, W. H., Kalia, L. V., Ahmadian, G., Wang, Y. T., & Salter, M. W. (2003) · Nature · doi:10.1038/nature01497 · Cited by 427
Modulation of N -methyl- d -aspartate receptor function by glycine transport
Bergeron, R., Meyer, T. M., Coyle, J. T., & Greene, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15730 · Cited by 418
Fluoxetine, Comprehensive Cognitive Behavioral Therapy, and Placeboin Generalized Social Phobia
Davidson, J. R. T., Foa, E. B., Huppert, J. D., Keefe, F. J., Franklin, M. E., Compton, J. S., Zhao, N., Connor, K. M., Lynch, T. R., & Gadde, K. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.10.1005 · Cited by 415
Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET)
Vollenweider, F. X., Leenders, K. L., Øye, I., Hell, D., & Angst, J. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00042-9 · Cited by 413
Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.805 · Cited by 392
Effects of D-cycloserine on extinction of conditioned freezing.
Ledgerwood, L., Richardson, R., & Cranney, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.341 · Cited by 388
D-Cycloserine Augmented Exposure Therapy for Obsessive-Compulsive Disorder
Kushner, M. G., Kim, S. W., Donahue, C. B., THURAS, P. D., Adson, D. E., Kotlyar, M., McCabe, J., Peterson, J., & Foa, E. B. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.020 · Cited by 384
The practice of behavior therapy
Scrignar, C. B. (1970) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(70)90060-1 · Cited by 381
Psychological treatment of panic: Work in progress on outcome, active ingredients, and follow-up
Margraf, J., Barlow, D. H., Clark, D. M., & Telch, M. J. (1993) · Behaviour Research and Therapy · doi:10.1016/0005-7967(93)90036-t · Cited by 377
The practice of behavior therapy, 2nd ed.
Wolpe, J. (1973) · Cited by 366
Augmentation of Behavior Therapy With d -Cycloserine for Obsessive-Compulsive Disorder
Wilhelm, S., Buhlmann, U., Tolin, D. F., Meunier, S. A., Pearlson, G. D., Reese, H. E., Cannistraro, P., Jenike, M. A., & Rauch, S. L. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050776 · Cited by 358
Self-citation
Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory
Santini, E., Muller, R. U., & Quirk, G. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-22-09009.2001 · Cited by 358
A Randomized Controlled Trial of D-Cycloserine Enhancement of Exposure Therapy for Social Anxiety Disorder
Guastella, A. J., Richardson, R., Lovibond, P. F., Rapee, R. M., Gaston, J. E., Mitchell, P., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.011 · Cited by 326
d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics
Hood, W. F., Compton, R. P., & Monahan, J. B. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90379-0 · Cited by 309
First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients
Pilowsky, L. S., Bressan, R. A., Stone, J. M., Erlandsson, K., Mulligan, R. S., Krystal, J. H., & Ell, P. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001751 · Cited by 278
Self-citation
Sarcosine or D-Serine Add-on Treatment for Acute Exacerbation of Schizophrenia
Lane, H., Chang, Y., Liu, Y., Chiu, C., & Tsai, G. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1196 · Cited by 271
Long-term outcome in cognitive-behavioral treatment of panic disorder: Clinical predictors and alternative strategies for assessment
Brown, T. A., & Barlow, D. H. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.5.754 · Cited by 262
d-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction
Ledgerwood, L., Richardson, R., & Cranney, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.023 · Cited by 249
Glycine Tranporter-1 Blockade Potentiates NMDA-Mediated Responses in Rat Prefrontal Cortical Neurons In Vitro and In Vivo
Chen, L., Muhlhauser, M. A., & Yang, C. R. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00680.2002 · Cited by 232
Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses
Royer, S., & Paré, D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00455-4 · Cited by 210
Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis
Tuominen, H. J., Tiihonen, J., & Wahlbeck, K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.05.005 · Cited by 209
D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder
Storch, E. A., Merlo, L. J., Bengtson, M., Murphy, T. K., Lewis, M. H., Yang, M. C., Jacob, M. L., Larson, M., Hirsh, A., Fernandez, M., et al. (2007) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32819f8480 · Cited by 200
Adjunctive high-dose glycine in the treatment of schizophrenia
Javitt, D. C., Silipo, G. S., Cienfuegos, A., Shelley, A. M., Bark, N. M., Park, M., Lindenmayer, J., Suckow, R. F., & Zukin, S. R. (2001) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002590 · Cited by 199
Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene
Borowsky, B., Mezey, É., & Hoffman, B. (1993) · Neuron · doi:10.1016/0896-6273(93)90201-2 · Cited by 195
D-Cycloserine and the Facilitation of Extinction of Conditioned Fear: Consequences for Reinstatement.
Ledgerwood, L., Richardson, R., & Cranney, J. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.3.505 · Cited by 194
Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype
Tsai, G. E., Ralph, R. J., Martina, M., Bergeron, R., Berger-Sweeney, J. E., Dunham, K. S., Jiang, Z., Caine, S. B., & Coyle, J. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402662101 · Cited by 192
Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications
Richardson, R., Ledgerwood, L., & Cranney, J. (2004) · Learning & Memory · doi:10.1101/lm.78204 · Cited by 185
The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.
Baker, J. D., & Azorlosa, J. L. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.3.618 · Cited by 179
The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.
Baker, J. D., & Azorlosa, J. L. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.3.618 · Cited by 179
d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed inXenopus oocytes
Watson, G. B., Bolanowski, M. A., Baganoff, M. P., Deppeler, C. L., & Lanthorn, T. H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90745-w · Cited by 172
The Glycine Transporter Type 1 InhibitorN-[3-(4′-Fluorophenyl)-3-(4′-Phenylphenoxy)Propyl]Sarcosine Potentiates NMDA Receptor-Mediated ResponsesIn Vivoand Produces an Antipsychotic Profile in Rodent Behavior
Kinney, G. G., Sur, C., Burno, M., Mallorga, P. J., Williams, J. B., Figueroa, D. J., Wittmann, M., Lemaire, W., & Conn, P. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07586.2003 · Cited by 172
Neurobiology of anxiety disorders and implications for treatment.
Garakani, A., Mathew, S. J., & Charney, D. S. (2006) · PubMed · Cited by 166
A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear
Guastella, A. J., Dadds, M. R., Lovibond, P. F., Mitchell, P., & Richardson, R. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.05.006 · Cited by 164
Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy*
Davis, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02138.x · Cited by 154
Role of the Amygdala in Fear Extinction Measured with Potentiated Startle
DAVIS, M., WALKER, D. L., & MYERS, K. M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07084.x · Cited by 152
d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference
Botreau, F., Paolone, G., & Stewart, J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.012 · Cited by 149
Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents
Adams, R., Sato, K., Shimada, S., Tohyama, M., Puschel, A., & Betz, H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02524.1995 · Cited by 148
Effects of multiple exposures to d-cycloserine on extinction of conditioned fear in rats
Parnas, A. S., Weber, M. F., & Richardson, R. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.01.001 · Cited by 146
Postsynaptically Silent Synapses in Single Neuron Cultures
Gomperts, S. N., Rao, A., Craig, A. M., Malenka, R. C., & Nicoll, R. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80662-5 · Cited by 142
Enhancing exposure-based therapy from a translational research perspective
Hofmann, S. G. (2007) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.06.006 · Cited by 138
The G72/G30 Gene Complex and Cognitive Abnormalities in Schizophrenia
Goldberg, T. E., Straub, R. E., Callicott, J. H., Hariri, A. R., Mattay, V. S., Bigelow, L. B., Coppola, R., Egan, M. F., & Weinberger, D. R. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301049 · Cited by 133
D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response
Woods, A. M., & Bouton, M. E. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.5.1159 · Cited by 133
Improved Cognition in Alzheimer’s Disease With Short-Term D-Cycloserine Treatment
Tsai, G. E., Falk, W. E., Gunther, J. M., & Coyle, J. T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.3.467 · Cited by 129
Augmentation Treatment of Psychotherapy for Anxiety Disorders with D‐Cycloserine
Hofmann, S. G., Pollack, M. H., & Otto, M. W. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00208.x · Cited by 123
Comparative effects of glycine and d-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis
Heresco‐Levy, U., & Javitt, D. C. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00129-4 · Cited by 121
A six-month, placebo-controlled trial of d-cycloserine co-administered with conventional antipsychotics in schizophrenia patients
GOFF, D. C., Herz, L. R., Posever, T. A., Shih, V. E., Tsai, G. E., Henderson, D. C., Freudenreich, O., Evins, A. E., Yovel, I., Zhang, H., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2032-2 · Cited by 116
Developmental Expression of the Glycine Transporters GLYT1 and GLYT2 in Mouse Brain
Jurský, F., & Nelson, N. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67010336.x · Cited by 113
Long‐term potentiation as a substrate for memory: Evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning
Goosens, K. A., & Maren, S. (2002) · Hippocampus · doi:10.1002/hipo.10099 · Cited by 112
Extinction Training in Conjunction with a Partial Agonist of the Glycine Site on the NMDA Receptor Erases Memory Trace
Mao, S.-C., Hsiao, Y., & Gean, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0365-06.2006 · Cited by 112
IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans
D’Souza, D. C., Gil, R. B., Cassello, K., Morrissey, K., Abi‐Saab, D., White, J., Sturwold, R., Bennett, A., Karper, L. P., Zuzarte, E., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00133-x · Cited by 111
Self-citation
Actions of ?-cycloserine at the ? glycine receptor site in vivo
Emmett, M. R. (1991) · Neuropharmacology · doi:10.1016/0028-3908(91)90161-4 · Cited by 108
A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans
Guastella, A. J., Lovibond, P. F., Dadds, M. R., Mitchell, P., & Richardson, R. (2007) · Behaviour Research and Therapy · doi:10.1016/j.brat.2006.07.005 · Cited by 106
White matter lesions in Fabry disease occur in ‘prior’ selectively hypometabolic and hyperperfused brain regions
Moore, D. F., Altarescu, G., Barker, W. C., Patronas, N. J., Herscovitch, P., & Schiffmann, R. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.021 · Cited by 101
Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala
Yang, Y.-L., & Lu, K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.003 · Cited by 93
Effects of d-cycloserine on negative symptoms in schizophrenia
Duncan, E., Szilagyi, S., Schwartz, M. P., Bugarski‐Kirola, D., Kunzova, A., Negi, S., Stephanides, M., Efferen, T. R., Angrist, B., Peselow, E. D., et al. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.03.013 · Cited by 90
Long-term memory of cocaine-associated context: disruption and reinstatement
Kelley, J. B., Anderson, K. L., & Itzhak, Y. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280c1e2e7 · Cited by 89
Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and α2-adrenergic agonists
Kim, S. H., Price, M. T., Olney, J. W., & Farber, N. B. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000529 · Cited by 86
Effects of D-cycloserine on extinction of learned fear to an olfactory cue
Weber, M., Hart, J., & Richardson, R. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.12.010 · Cited by 83
Glutamate NMDA Receptors within the Amygdala Participate in the Modulatory Effect of Glucocorticoids on Extinction of Conditioned Fear in Rats
Yang, Y.-L., Chao, P.-K., Ro, L., Wo, Y., & Lu, K.-T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301215 · Cited by 79
The NMDA receptor antagonist MK-801 blocks acquisition and extinction of conditioned hypoalgesic responses in the rat.
Cox, J., & Westbrook, R. F. (1994) · PubMed · Cited by 74
D-cycloserine for Alzheimer's disease
Jones, R. W., Laake, K., & Øksengård, A. R. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003153 · Cited by 72
Influence of ethanol withdrawal on fear memory: Effect of d-cycloserine
Bertotto, M. E., Bustos, S. G., Molina, V. A., & Martijena, I. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.013 · Cited by 70
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures
Boje, K. M., Wong, G., & Skolnick, P. (1993) · Brain Research · doi:10.1016/0006-8993(93)91239-o · Cited by 69
Glycine Site Agonists of the NMDA Receptor: A Review
D’Souza, D. C., Charney, D. S., & Krystal, J. H. (1995) · CNS Drug Reviews · doi:10.1111/j.1527-3458.1995.tb00285.x · Cited by 57
Self-citation
D-Cycloserine Treatment of Alzheimer Disease
RANDOLPH, C. C., Roberts, J. W., Tierney, M. C., Bravi, D., Mouradian, M. M., & Chase, T. N. (1994) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199408030-00006 · Cited by 53
Clinical perspectives on the combination of D-cycloserine and cognitive-behavioral therapy for the treatment of anxiety disorders.
Otto, M. W., Basden, S. L., Leyro, T. M., McHugh, R. K., & Hofmann, S. G. (2007) · CNS Spectrums · doi:10.1017/s1092852900020526 · Cited by 53
Evaluation of Cycloserine in the Treatment of Alzheimer's Disease
Fakouhi, T. D., Jhee, S. S., Sramek, J. J., Benes, C. O., Schwartz, P., Hantsburger, G., Herting, R. L., Swabb, E. A., & Cutler, N. R. (1995) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879500800405 · Cited by 51
Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices
Huang, H., Barakat, L., Wang, D. D., & Bordey, A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.067801 · Cited by 50
Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo
Kikuchi, T., Wang, Y., Shinbori, H., Sato, K., & Okumura, F. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/79.1.128 · Cited by 49
Facilitation of Extinction of Conditioned Fear by D-Cycloserine: Implications for Psychotherapy
Davis, M., Myers, K. M., Ressler, K. J., & Rothbaum, B. O. (2005) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2005.00367.x · Cited by 43
Effects of D-Cycloserine on Extinction: Consequences of Prior Exposure to Imipramine
Werner-Seidler, A., & Richardson, R. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.010 · Cited by 43
Delay aversion: Effects of 7-OH-DPAT, 5-HT1A/1B-receptor stimulation and d-cycloserine
van den Bergh, F. S., Bloemarts, E., Groenink, L., Olivier, B., & Oosting, R. S. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.007 · Cited by 42
NMDA Partial Agonist Reverses Blocking of Extinction of Aversive Memory by GABAA Agonist in the Amygdala
Akirav, I. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301050 · Cited by 41
d-Cycloserine and performance under different states of anxiety in healthy volunteers
Bailey, J., Papadopoulos, A., Lingford-Hughes, A. R., & Nutt, D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0817-9 · Cited by 37
Neuroplasticity as a Target for the Pharmacotherapy of Psychiatric Disorders: New Opportunities for Synergy with Psychotherapy
Krystal, J. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.08.017 · Cited by 34
Self-citation
D-Cycloserine enhances memory consolidation of hippocampus-dependent latent extinctionPreprint
Gabriele, A., & Packard, M. G. (2007) · Learning & Memory · doi:10.1101/lm.528007 · Cited by 32
The Glial and the Neuronal Glycine Transporters Differ in Their Reactivity to Sulfhydryl Reagents
Roux, M. J., Maza, R. M., Goff, A. L., López‐Corcuera, B., Aragón, C., & Supplisson, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009196200 · Cited by 31
Pharmacotherapy for performance anxiety disorders: occasionally useful but typically contraindicated.
Birk, L. (2004) · Journal of Clinical Psychology · doi:10.1002/jclp.20044 · Cited by 31
Emotional Learning and Glutamate: Translational Perspectives
Gillespie, C. F., & Ressler, K. J. (2005) · CNS Spectrums · doi:10.1017/s1092852900010439 · Cited by 27
Manipulation of NMDA-receptor activity alters extinction of an instrumental response in rats
Port, R. L., & Seybold, K. S. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00095-x · Cited by 25
Effects of light deprivation on recovery from neglect and extinction induced by unilateral lesions of the medial agranular cortex and dorsocentral striatum
Vleet, T. V., Heldt, S. A., Pyter, B., Corwin, J. V., & Reep, R. L. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00246-2 · Cited by 22
Unilateral destruction of the dorsocentral striatum in rats produces neglect but not extinction to bilateral simultaneous stimulation
VanVleet, T. M., Heldt, S. A., Guerrettaz, K. R., Corwin, J. V., & Reep, R. L. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00296-6 · Cited by 20
Glycine ketamine interactions in healthy humans
D’Souza, D. C., Gil, R. B., Zuzarte, E., Abi‐Saab, D., Damon, D., White, J., Zimmerman, L., & Krystal, J. H. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)82609-6 · Cited by 18
Self-citation
D-cycloserine Inhibits Amygdala Responses During Repeated Presentations of Faces
Britton, J. C., Gold, A. L., Feczko, E., Rauch, S. L., Williams, D., & Wright, C. I. (2007) · CNS Spectrums · doi:10.1017/s1092852900021398 · Cited by 16
Quantitative gene expression of two types of glycine transporter in the rat central nervous system
Goebel, D. J. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00079-4 · Cited by 14
Effects of activation and blockade of NMDA receptors on the extinction of a conditioned passive avoidance response in mice with different levels of anxiety
Tomilenko, R. A., & Dubrovina, N. I. (2007) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-007-0044-1 · Cited by 14

Flagged first, then by citations

Research works printed but not linked: 1

Ledgerwood, 2004, D-cycloserine and the facilitation of extinction of conditioned fear: Consequences for reinstatement, Behav Neurosci, 118, 505, 10.1037/0735-7044.118.3.505 · DOI

Sorted by citations

Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision
Bandelow, B., Zohar, J., Hollander, E., Kasper, S., Möller, H., & WFSBP Task Force on Treatment Guide (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970802465807 · Cited by 887
Obsessive-compulsive disorder: An integrative genetic and neurobiological perspective
Pauls, D. L., Abramovitch, A., Rauch, S. L., & Geller, D. A. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3746 · Cited by 793
The biomedical model of mental disorder: A critical analysis of its validity, utility, and effects on psychotherapy research
Deacon, B. J. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.09.007 · Cited by 756
Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder
Mahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 643

See all 510

Authors: Norberg, M. M., Krystal, J. H., & Tolin, D. F.
Affiliations: Yale University (US)
Corresponding author: Tolin, David F.
ORCID: Norberg, Melissa M.
Krystal, John H.
Tolin, David F.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-06
Volume: 63
Issue: 12
Pages: 1118-1126
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2008.01.012
OpenAlex: W2159630298
Cited by: 510
References: 121
Citations by year: 2026: 10 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 15 · 2021: 13 · 2020: 12 · 2019: 16 · 2018: 28 · 2017: 28 · 2016: 23 · 2015: 50 · 2014: 37 · 2013: 53 · 2012: 51
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: D-cycloserine, fear extinction, exposure therapy, NMDA receptor agonist, anxiety disorders, fear memory consolidation, neuroplasticity, augmentation therapy, translational research
MeSH terms: Animals, Anxiety Disorders, Combined Modality Therapy, Cycloserine, Desensitization, Psychologic, Extinction, Psychological, Fear, Humans, Implosive Therapy, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Meta-Analysis of D-Cycloserine and the Facilitation of Fear Extinction and Exposure Therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks