Cited by 226Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

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Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder

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Phan, K. Luan, Orlichenko, Anton, Boyd, Erin, Angstadt, Mike, Coccaro, Emil F., Liberzon, Israel, Arfanakis, Konstantinos·2009·Biological Psychiatry

DOI 10.1016/j.biopsych.2009.02.028PMC PMC2743779

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Abstract

Background Individuals with generalized social anxiety disorder (GSAD) exhibit exaggerated amygdala reactivity to aversive social stimuli. These findings could be explained by microstructural abnormalities in white matter (WM) tracts that connect the amygdala and prefrontal cortex, which is known to modulate the amygdala's response to threat. The goal of this study was to investigate brain frontal WM abnormalities using diffusion tensor imaging (DTI) in patients with social anxiety disorder.Methods A Turboprop DTI sequence was used to acquire diffusion tensor images in 30 patients with GSAD and 30 matched healthy control subjects. Fractional anisotropy, an index of axonal organization, within WM was quantified in individual subjects, and an automated voxel-based, whole-brain method was used to analyze group differences.Results Compared with healthy control subjects, patients had significantly lower fractional anisotropy localized to the right uncinate fasciculus WM near the orbitofrontal cortex. There were no areas of higher fractional anisotropy in patients than controls.Conclusions These findings point to an abnormality in the uncinate fasciculus, the major WM tract connecting the frontal cortex to the amygdala and other limbic temporal regions, in GSAD, which could underlie the aberrant amygdala-prefrontal interactions resulting in dysfunctional social threat processing in this illness.

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“…SAD. with respect to white matter integrity, individuals with overall SAD have shown reductions in major tracts, including the uncinate fasciculus (Phan et al. 2009; Baur et al. 2011), superior longitudinal fasciculus (Baur et al. 2011; tükel et al. 2017), and inferior longitudinal fasciculus…”
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Authors: Phan, K. L., Orlichenko, A., Boyd, E., Angstadt, M., Coccaro, E. F., Liberzon, I., & Arfanakis, K.
Affiliations: University of Michigan (US)
Illinois Institute of Technology (US)
ORCID: Phan, K. Luan
Orlichenko, Anton
Angstadt, Mike
Coccaro, Emil F.
Liberzon, Israel
Arfanakis, Konstantinos
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-10
Volume: 66
Issue: 7
Pages: 691-694
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2009.02.028
PMC: PMC2743779
OpenAlex: W2049830989
Cited by: 226
References: 40
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 14 · 2021: 10 · 2020: 19 · 2019: 20 · 2018: 6 · 2017: 18 · 2016: 17 · 2015: 18 · 2014: 16 · 2013: 22 · 2012: 19
FWCI: 17.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (K23MH076198)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: generalized social anxiety disorder, uncinate fasciculus, white matter microstructure, fractional anisotropy, amygdala-prefrontal connectivity, orbitofrontal cortex, limbic system, diffusion tensor imaging
MeSH terms: Adult, Brain Mapping, Female, Frontal Lobe, Humans, Limbic System, Male, Nerve Fibers, Myelinated, Neural Pathways, Neuropsychological Tests, Phobic Disorders, Psychiatric Status Rating Scales, Case-Control Studies, Anisotropy, Diffusion Magnetic Resonance Imaging, Young Adult

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Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder

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