Cited by 226Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder

Open access

Phan, K. Luan, Orlichenko, Anton, Boyd, Erin, Angstadt, Mike, Coccaro, Emil F., Liberzon, Israel, Arfanakis, Konstantinos·2009·Biological Psychiatry

DOI 10.1016/j.biopsych.2009.02.028PMC PMC2743779

Open this paper in CoChat — free account

Abstract

Background Individuals with generalized social anxiety disorder (GSAD) exhibit exaggerated amygdala reactivity to aversive social stimuli. These findings could be explained by microstructural abnormalities in white matter (WM) tracts that connect the amygdala and prefrontal cortex, which is known to modulate the amygdala's response to threat. The goal of this study was to investigate brain frontal WM abnormalities using diffusion tensor imaging (DTI) in patients with social anxiety disorder.Methods A Turboprop DTI sequence was used to acquire diffusion tensor images in 30 patients with GSAD and 30 matched healthy control subjects. Fractional anisotropy, an index of axonal organization, within WM was quantified in individual subjects, and an automated voxel-based, whole-brain method was used to analyze group differences.Results Compared with healthy control subjects, patients had significantly lower fractional anisotropy localized to the right uncinate fasciculus WM near the orbitofrontal cortex. There were no areas of higher fractional anisotropy in patients than controls.Conclusions These findings point to an abnormality in the uncinate fasciculus, the major WM tract connecting the frontal cortex to the amygdala and other limbic temporal regions, in GSAD, which could underlie the aberrant amygdala-prefrontal interactions resulting in dysfunctional social threat processing in this illness.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2009.02.028

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen‐Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,598
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495
Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391
Extinction Learning in Humans
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Principles of diffusion tensor imaging and its applications to basic neuroscience research
Mori, S., & Zhang, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.012 · Cited by 1,708
Social anxiety disorder
Stein, M. B., & Stein, D. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60488-2 · Cited by 1,137
MRI Atlas of Human White Matter
Mori, S. (2005) · Cited by 1,103
MRI atlas of human white matter
Ling, C. L., & Rumpel, H. (2006) · Concepts in Magnetic Resonance Part A · doi:10.1002/cmr.a.20052 · Cited by 1,021
The Liebowitz Social Anxiety Scale: a comparison of the psychometric properties of self-report and clinician-administered formats
FRESCO, D. M., COLES, M. E., HEIMBERG, R. G., LIEBOWITZ, M. R., HAMI, S., STEIN, M. B., & GOETZ, D. (2001) · Psychological Medicine · doi:10.1017/s0033291701004056 · Cited by 874
Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala
Ghashghaei, H. T., Hilgetag, C. C., & Barbas, H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.046 · Cited by 845

Show all 40 references

Sorted by citations

Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473
The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety
Kim, M. J., Loucks, R. A., Palmer, A. L., Brown, A. C., Solomon, K. M., Marchante, A. N., & Whalen, P. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.025 · Cited by 838
Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis.
Von Der Heide, R. J., Skipper, L. M., Klobusicky, E., & Olson, I. R. (2013) · Brain · doi:10.1093/brain/awt094 · Cited by 829
Resting state functional connectivity in addiction: Lessons learned and a road ahead
Sutherland, M. T., McHugh, M. J., Pariyadath, V., & Stein, E. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.117 · Cited by 509
Neuroimaging in social anxiety disorder—A meta-analytic review resulting in a new neurofunctional model
Brühl, A. B., Delsignore, A., Komossa, K., & Weidt, S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.003 · Cited by 439
Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder
Hahn, A., Stein, P., Windischberger, C., Weissenbacher, A., Spindelegger, C., Moser, E., Kasper, S., & Lanzenberger, R. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.064 · Cited by 385
Brain default-mode network dysfunction in addiction
Zhang, R., & Volkow, N. D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.036 · Cited by 386
Brain connectomics predict response to treatment in social anxiety disorder
Whitfield-Gabrieli, S., Ghosh, S. S., Nieto-Castanon, A., Saygin, Z., Doehrmann, O., Chai, X. J., Reynolds, G. O., Hofmann, S. G., Pollack, M. H., & Gabrieli, J. D. E. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.109 · Cited by 210
How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways
Moylan, S., Jacka, F. N., Pasco, J. A., & Berk, M. (2013) · Brain and Behavior · doi:10.1002/brb3.137 · Cited by 186
Reduced Structural Connectivity of a Major Frontolimbic Pathway in Generalized Anxiety Disorder
Tromp, D. P. M., Grupe, D. W., Oathes, D. J., McFarlin, D. R., Hernandez, P. J., Kral, T. R. A., Lee, J. E., Adams, M., Alexander, A. L., & Nitschke, J. B. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2178 · Cited by 184
Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder
Klumpp, H., Angstadt, M., & Phan, K. L. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.10.010 · Cited by 180
Self-citation
Age-related changes in the structure and function of prefrontal cortex–amygdala circuitry in children and adolescents: A multi-modal imaging approach
Swartz, J. R., Carrasco, M., Wiggins, J. L., Thomason, M. E., & Monk, C. S. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.018 · Cited by 158
Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder
Liao, W., Xu, Q., Mantini, D., Ding, J., Machado‐de‐Sousa, J. P., Hallak, J. E. C., Trzesniak, C. M. F., Qiu, C., Zeng, L., Zhang, W., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.018 · Cited by 160
Disrupted effective connectivity between the amygdala and orbitofrontal cortex in social anxiety disorder during emotion discrimination revealed by dynamic causal modeling for fMRI
Sladky, R., Höflich, A., Küblböck, M., Kraus, C., Baldinger, P., Moser, E., Lanzenberger, R., & Windischberger, C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht279 · Cited by 152
Left and right hemispheric lateralization of the amygdala in pain
Allen, H. N., Bobnar, H. J., & Kolber, B. J. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101891 · Cited by 151
Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome
Ellingson, B. M., Mayer, E. A., Harris, R. J., Ashe-McNalley, C., Naliboff, B. D., Labus, J. S., & Tillisch, K. (2013) · Pain · doi:10.1016/j.pain.2013.04.010 · Cited by 156
Shared white matter alterations across emotional disorders: A voxel-based meta-analysis of fractional anisotropy
Jenkins, L. M., Barba, A., Campbell, M. L., Lamar, M., Shankman, S. A., Leow, A., Ajilore, O., & Langenecker, S. A. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.09.001 · Cited by 153
Antenatal Maternal Anxiety Predicts Variations in Neural Structures Implicated in Anxiety Disorders in Newborns
Rifkin-Graboi, A. E., Meaney, M. J., Chen, H., Bai, J., Hameed, W. B., Tint, M. T., Broekman, B. F. P., Chong, Y. S., Gluckman, P. D., Fortier, M. V., et al. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.01.013 · Cited by 140
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity
Sampath, D., Sathyanesan, M., & Newton, S. S. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s136122 · Cited by 145
Circuit-Wide Structural and Functional Measures Predict Ventromedial Prefrontal Cortex Fear Generalization: Implications for Generalized Anxiety Disorder
Cha, J., Greenberg, T., Carlson, J. M., DeDora, D. J., Hajcak, G., & Mujica-Parodi, L. R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3372-13.2014 · Cited by 147
White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder
Fani, N., King, T. Z., Jovanovic, T., Glover, E. M., Bradley, B., Choi, K., Ely, T., Gutman, D. A., & Ressler, K. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.146 · Cited by 135
Social fearfulness in the human brain
Miskovic, V., & Schmidt, L. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.08.002 · Cited by 126
Profiles of white matter tract pathology in frontotemporal dementia
Mahoney, C. J., Ridgway, G. R., Malone, I. B., Downey, L. E., Beck, J., Kinnunen, K. M., Schmitz, N., Golden, H. L., Rohrer, J. D., Schott, J. M., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22468 · Cited by 124
Quantitative tract-specific measures of uncinate and cingulum in major depression using diffusion tensor imaging
Zhang, A., Leow, A., Ajilore, O., Lamar, M., Yang, S., Joseph, J., Medina, J., Zhan, L., & Kumar, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.279 · Cited by 121
Revisiting the human uncinate fasciculus, its subcomponents and asymmetries with stem-based tractography and microdissection validation
Hau, J., Sarubbo, S., Houde, J. C., Corsini, F., Girard, G., Deledalle, C., Crivello, F., Zago, L., Mellet, E., Jobard, G., et al. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1298-6 · Cited by 121
Volumetric associations between uncinate fasciculus, amygdala, and trait anxiety
Baur, V., Hänggi, J., & Jäncke, L. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-4 · Cited by 121
Linking an Anxiety-Related Personality Trait to Brain White Matter Microstructure
Westlye, L. T., Bjørnebekk, A., Grydeland, H., Fjell, A. M., & Walhovd, K. B. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.24 · Cited by 121
Amygdala in action: Relaying biological and social significance to autobiographical memory
Markowitsch, H. J., & Staniloiu, A. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.10.007 · Cited by 121
Brain white matter microstructure alterations in adolescent rhesus monkeys exposed to early life stress: associations with high cortisol during infancy
Howell, B., McCormack, K. M., Grand, A. P., Sawyer, N. T., Zhang, X., Maestripieri, D., Hu, X. P., & Sánchez, M. M. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-21 · Cited by 112
Grey matter abnormalities in social anxiety disorder: a pilot study
Syal, S., Hattingh, C. J., Fouché, J., Spottiswoode, B. S., Carey, P. D., Löchner, C., & Stein, D. J. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9299-5 · Cited by 102
Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species
Gee, D. G., Fetcho, R. N., Jing, D., Li, A., Glatt, C. E., Drysdale, A. T., Cohen, A. O., Dellarco, D. V., Yang, R. R., Dale, A. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600013113 · Cited by 106
White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration
Downey, L. E., Mahoney, C. J., Buckley, A. H., Golden, H. L., Henley, S. M., Schmitz, N., Schott, J. M., Simpson, I. J., Ourselin, S., Fox, N. C., et al. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.06.005 · Cited by 94
Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder
Månsson, K. N. T., Carlbring, P., Frick, A., Engman, J., Olsson, C.-J., Bodlund, O., Furmark, T., & Andersson, G. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.08.012 · Cited by 92
Altered fusiform connectivity during processing of fearful faces in social anxiety disorder
Frick, A., Howner, K., Fischer, H., Kristiansson, M., & Furmark, T. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.85 · Cited by 91
Pilot multimodal twin imaging study of generalized anxiety disorder
Hettema, J. M., Kettenmann, B., Ahluwalia, V., McCarthy, C., Kates, W. R., Schmitt, J. E., Silberg, J. L., Neale, M. C., Kendler, K. S., & Fatouros, P. P. (2011) · Depression and Anxiety · doi:10.1002/da.20901 · Cited by 96
Structural evidence for involvement of a left amygdala-orbitofrontal network in subclinical anxiety
Blackmon, K., Barr, W. B., Carlson, C., Devinsky, O., DuBois, J., Pogash, D., Quinn, B. T., Kuzniecky, R., Halgren, E., & Thesen, T. (2011) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.05.007 · Cited by 90
Toward personalized medicine in connectomic deep brain stimulation
Hollunder, B., Rajamani, N., Siddiqi, S., Finke, C., Kühn, A. A., Mayberg, H. S., Fox, M., Neudorfer, C., & Horn, A. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102211 · Cited by 89
Evidence of frontotemporal structural hypoconnectivity in social anxiety disorder: A quantitative fiber tractography study
Baur, V., Brühl, A. B., Herwig, U., Eberle, T., Rufer, M., Delsignore, A., Jäncke, L., & Hänggi, J. (2011) · Human Brain Mapping · doi:10.1002/hbm.21447 · Cited by 88
Diffusion Tensor Imaging in Anxiety Disorders
Ayling, E., Aghajani, M., Fouché, J., & van der Wee, N. J. A. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0273-z · Cited by 87
Increased cortical thickness in a frontoparietal network in social anxiety disorder
Brühl, A. B., Hänggi, J., Baur, V., Rufer, M., Delsignore, A., Weidt, S., Jäncke, L., & Herwig, U. (2013) · Human Brain Mapping · doi:10.1002/hbm.22378 · Cited by 90
White matter alterations in social anxiety disorder
Baur, V., Hänggi, J., Rufer, M., Delsignore, A., Jäncke, L., Herwig, U., & Beatrix Brühl, A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.05.007 · Cited by 86
Increased neural habituation in the amygdala and orbitofrontal cortex in social anxiety disorder revealed by FMRI
Sladky, R., Höflich, A., Atanelov, J., Kraus, C., Baldinger, P., Moser, E., Lanzenberger, R., & Windischberger, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050050 · Cited by 85
How Socioeconomic Disadvantages Get Under the Skin and into the Brain to Influence Health Development Across the Lifespan
Kim, P., Evans, G. W., Chen, E., Miller, G. E., & Seeman, T. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-47143-3_19 · Cited by 92
STRUCTURAL AND FUNCTIONAL CONNECTIVITY IN POSTTRAUMATIC STRESS DISORDER: ASSOCIATIONS WITH FKBP5: 2015 Donald F Klein Investigator Award Finalist: Connectivity, PTSD, and FKBP5
Fani, N., King, T. Z., Shin, J., Srivastava, A., Brewster, R. C., Jovanovic, T., Bradley, B., & Ressler, K. J. (2016) · Depression and Anxiety · doi:10.1002/da.22483 · Cited by 80
White Matter Involvement in Chronic Musculoskeletal Pain
Lieberman, G., Shpaner, M., Watts, R., Andrews, T. J., Filippi, C. G., Davis, M., & Naylor, M. R. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.08.002 · Cited by 84
Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults
Xie, S., Zhang, X., Cheng, W., & Yang, Z. (2021) · General Psychiatry · doi:10.1136/gpsych-2020-100411 · Cited by 78
Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders
Meyer, H. C., & Lee, F. S. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19010091 · Cited by 80
Maternal Prenatal Stress Is Associated With Altered Uncinate Fasciculus Microstructure in Premature Neonates
Lautarescu, A., Pecheva, D., Nosarti, C., Sigurðardottir, J. N., Zhang, H. G., Victor, S., Craig, M., Edwards, A. D., & Counsell, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.010 · Cited by 79
White-Matter Microstructural Changes in Functional Dyspepsia: A Diffusion Tensor Imaging Study
Zhou, G., Qin, W., Zeng, F., Liu, P., Yang, X., von Deneen, K. M., Gong, Q., Liang, F., & Tian, J. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.405 · Cited by 71
Individual differences in trait anxiety are associated with white matter tract integrity in the left temporal lobe in healthy males but not females
Montag, C., Reuter, M., Weber, B., Markett, S. A., & Schoene‐Bake, J. ‐. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.017 · Cited by 76
White matter integrity alterations in post‐traumatic stress disorder
O'Doherty, D. C. M., Ryder, W., Paquola, C., Tickell, A. M., Chan, C., Hermens, D. F., Bennett, M. R., & Lagopoulos, J. (2017) · Human Brain Mapping · doi:10.1002/hbm.23920 · Cited by 75
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 72
Alterations in white matter pathways in Angelman syndrome
PETERS, S. U., KAUFMANN, W. E., BACINO, C. A., ANDERSON, A. W., ADAPA, P., CHU, Z., YALLAMPALLI, R., TRAIPE, E., HUNTER, J. V., & WILDE, E. A. (2011) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2010.03838.x · Cited by 69
Structural connections support emotional connections: Uncinate Fasciculus microstructure is related to the ability to decode facial emotion expressions
Coad, B. M., Postans, M., Hodgetts, C. J., Muhlert, N., Graham, K. S., & Lawrence, A. D. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.11.006 · Cited by 75
A narrative review of the anatomy and function of the white matter tracts in language production and comprehension
Shekari, E., & Nozari, N. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1139292 · Cited by 73
The Effects of Chronic Stress on Brain Myelination in Humans and in Various Rodent Models
Antontseva, E. V., Bondar, N. P., Reshetnikov, V. V., & Merkulova, T. I. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.013 · Cited by 68
Investigating the links between adolescent sleep deprivation, fronto-limbic connectivity and the Onset of Mental Disorders: a review of the literature
Jamieson, D., Broadhouse, K. M., Lagopoulos, J., & Hermens, D. F. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.08.013 · Cited by 64
Neurobiological candidate endophenotypes of social anxiety disorder
Bas‐Hoogendam, J. M., Blackford, J. U., Brühl, A. B., Blair, K. S., van der Wee, N. J. A., & Westenberg, P. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.040 · Cited by 68
Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola, P., & Gee, D. G. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20020232 · Cited by 62
A network of amygdala connections predict individual differences in trait anxiety
Greening, S. G., & Mitchell, D. G. V. (2015) · Human Brain Mapping · doi:10.1002/hbm.22952 · Cited by 70
Physical neglect during childhood alters white matter connectivity in healthy young males
Tendolkar, I., Mårtensson, J., Kühn, S., Klumpers, F., & Fernández, G. (2017) · Human Brain Mapping · doi:10.1002/hbm.23916 · Cited by 64
The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
Long, H., Liu, B., Hou, B., Wang, C., Li, J., Qin, W., Wang, D., Zhou, Y., Kendrick, K. M., Yu, C., et al. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1299-x · Cited by 59
Cognitive functioning in a population-based sample of young adults with anxiety disorders
Castaneda, A. E., Suvisaari, J. V. J., MARTTUNEN, M. J., Perälä, J., Saarni, S. I., Aalto‐Setälä, T., Lönnqvist, J., & Tuulio‐Henriksson, A. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2009.11.006 · Cited by 56
Mindfulness-Based Stress Reduction, Fear Conditioning, and The Uncinate Fasciculus: A Pilot Study
Hölzel, B. K., Brunsch, V., Gard, T., Greve, D. N., Koch, K., Sorg, C., Lazar, S. W., & Milad, M. R. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00124 · Cited by 56
Pattern of structural brain changes in social anxiety disorder after cognitive behavioral group therapy: a longitudinal multimodal MRI study
Steiger, V. R., Brühl, A. B., Weidt, S., Delsignore, A., Rufer, M., Jäncke, L., Herwig, U., & Hänggi, J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.217 · Cited by 56
White matter microstructure in body dysmorphic disorder and its clinicalcorrelates
Feusner, J. D., Arienzo, D., Li, W., Zhan, L., GadElkarim, J., Thompson, P. M., & Leow, A. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.11.001 · Cited by 55
A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing
Allen, H. N., Chaudhry, S., Hong, V. M., Lewter, L. A., Sinha, G. P., Carrasquillo, Y., Taylor, B. K., & Kolber, B. J. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.010 · Cited by 51
Altered Resting-State Functional Connectivity of the Frontal-Striatal Reward System in Social Anxiety Disorder
Manning, J., Reynolds, G., Saygin, Z. M., Hofmann, S. G., Pollack, M. H., Gabrieli, J. D. E., & Whitfield, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125286 · Cited by 50
Altered executive control network resting-state connectivity in social anxiety disorder
Geiger, M. J., Domschke, K., Ipser, J., Hattingh, C., Baldwin, D. S., Löchner, C., & Stein, D. J. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1083613 · Cited by 49
White matter microstructure of the uncinate fasciculus is associated with subthreshold posttraumatic stress disorder symptoms and fear potentiated startle during early extinction in recently deployed Service Members
Costanzo, M. E., Jovanović, T., Pham, D. L., Leaman, S. C., Highland, K. B., Norrholm, S. D., & Roy, M. J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.041 · Cited by 49
Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls
Tromp, D., Williams, L. E., Fox, A. S., Oler, J. A., Roseboom, P. H., Rogers, G. M., Benson, B. E., Alexander, A. L., Pine, D. S., & Kalin, N. H. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18040425 · Cited by 49
Maternal buffering beyond glucocorticoids: impact of early life stress on corticolimbic circuits that control infant responses to novelty
Howell, B., McMurray, M. S., Guzman, D., Nair, G., Shi, Y., McCormack, K. M., Hu, X. P., Styner, M. A., & Sánchez, M. M. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1200481 · Cited by 48
The association between the 5-HTTLPR and neural correlates of fear conditioning and connectivity
Klucken, T., Schweckendiek, J., Blecker, C. R., Walter, B., Kuepper, Y., Hennig, J., & Stark, R. M. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu108 · Cited by 47
Development of a computerized adaptive screening tool for overall psychopathology (“p”)
Moore, T. M., Calkins, M. E., Satterthwaite, T. D., Roalf, D. R., Rosen, A. F. G., Gur, R. C., & Gur, R. E. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.028 · Cited by 44
Diffusion MRI properties of the human uncinate fasciculus correlate with the ability to learn visual associations.
Thomas, C., Avram, A., Pierpaoli, C., & Baker, C. (2015) · Cortex · doi:10.1016/j.cortex.2015.01.023 · Cited by 44
Being born small for gestational age reduces white matter integrity in adulthood: a prospective cohort study
Eikenes, L., Martinussen, M., Lund, L., Løhaugen, G. C. C., Indredavik, M. S., Jacobsen, G. W., Skranes, J. S., Brubakk, A., & Haberg, A. K. (2012) · Pediatric Research · doi:10.1038/pr.2012.129 · Cited by 44
Disease severity is correlated to tract specific changes of fractional anisotropy in MD and CM thalamus—A DTI study in major depressive disorder
Osoba, A., Hänggi, J., Li, M., Horn, D. I., Metzger, C. D., Eckert, U., Kaufmann, J., Zierhut, K. C., Steiner, J. H., Schiltz, K., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.12.026 · Cited by 44
White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder
Zhang, Y., Li, L., Yu, R., Liu, J., Tang, J., Tan, L., Liao, M., Yang, F., & Shan, B. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.060 · Cited by 45
White matter microstructure predicts longitudinal social cognitive outcomes after paediatric traumatic brain injury: a diffusion tensor imaging study
Ryan, N. P., Genc, S., Beauchamp, M. H., Yeates, K. O., Hearps, S. J. C., Catroppa, C., Anderson, V. A., & Silk, T. J. (2017) · Psychological Medicine · doi:10.1017/s0033291717002057 · Cited by 44
Regional brain volumes in body dysmorphic disorder compared to controls
Buchanan, B. G., Rossell, S. L., Maller, J. J., Toh, W. L., Brennan, S., & Castle, D. J. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413520253 · Cited by 42
Functional (dissociative) retrograde amnesia
Markowitsch, H. J., & Staniloiu, A. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-801772-2.00036-9 · Cited by 41
A meta-analysis on the uncinate fasciculus in depression
Xu, E. P., Nguyen, L. T., Leibenluft, E., Stange, J. P., & Linke, J. O. (2023) · Psychological Medicine · doi:10.1017/s0033291723000107 · Cited by 45
Neuroimaging in Anxiety Disorders
Fredrikson, M. G., & Faria, V. (2013) · Modern trends in psychiatry · doi:10.1159/000351938 · Cited by 42
Cerebral white matter structure is disrupted in Gulf War Veterans with chronic musculoskeletal pain
Riper, S. M. V., Alexander, A. L., Koltyn, K. F., Stegner, A. J., Ellingson, L. D., Destiche, D. J., Dougherty, R. J., Lindheimer, J. B., & Cook, D. B. (2017) · Pain · doi:10.1097/j.pain.0000000000001038 · Cited by 41
OFC and its connectivity with amygdala as predictors for future social anxiety in adolescents
Mao, Y., Zuo, X., Ding, C., & Qiu, J. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100804 · Cited by 43
Injured brain regions associated with anxiety in Vietnam veterans
Knutson, K. M., Rakowsky, S. T., Solomon, J. M., Krüeger, F., Raymont, V., Tierney, M. C., Wassermann, E. M., & Grafman, J. H. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.01.003 · Cited by 41
Social Subordination Stress and Serotonin Transporter Polymorphisms: Associations With Brain White Matter Tract Integrity and Behavior in Juvenile Female Macaques
Howell, B., Godfrey, J., Gutman, D. A., Michopoulos, V., Zhang, X., Nair, G., Hu, X. P., Wilson, M. E., & Sánchez, M. M. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht187 · Cited by 40
Influence of the BDNF Genotype on Amygdalo-Prefrontal White Matter Microstructure is Linked to Nonconscious Attention Bias to Threat
Carlson, J. M., Cha, J., Harmon‐Jones, E., Mujica-Parodi, L. R., & Hajcak, G. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht089 · Cited by 43
Fronto-occipital fasciculus, corpus callosum and superior longitudinal fasciculus tract alterations of first-episode, medication-naïve and late-onset panic disorder patients
Lai, C., & Wu, Y. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.09.022 · Cited by 38
A comparison of structural connectivity in anxious depression versus non-anxious depression
Delaparte, L., Yeh, F.-C. F., Adams, P., Malchow, A. L., Trivedi, M. H., Oquendo, M. A., Deckersbach, T., Ogden, R. T., Pizzagalli, D. A., D, M. F. M., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.01.012 · Cited by 37
Uncinate fasciculus fractional anisotropy correlates with typical use of reappraisal in women but not men.
Zuurbier, L. A., Nikolova, Y. S., Åhs, F., & Hariri, A. R. (2013) · Emotion · doi:10.1037/a0031163 · Cited by 38
Anxiety in transition: Neuroendocrine mechanisms supporting the development of anxiety pathology in adolescence and young adulthood
Spielberg, J. M., Schwarz, J. M., & Matyi, M. A. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100791 · Cited by 37
Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage
Genc, S., Malpas, C. B., Gülenç, A., Sciberras, E., Efron, D., Silk, T. J., & Seal, M. L. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100853 · Cited by 37
Implications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz, E. R., Gee, D. G., Pine, D. S., & Silverman, W. K. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.01.005 · Cited by 35
Neuropsychological impairments in panic disorder: A systematic review
O׳Sullivan, K., & Newman, E. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.024 · Cited by 33
Brain white matter organisation in adolescence is related to childhood cerebral responses to facial expressions and harm avoidance
Taddei, M., Tettamanti, M., Zanoni, A., Cappa, S. F., & Battaglia, M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.062 · Cited by 33
Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood
Morriss, J., Christakou, A., & van Reekum, C. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-44150-1 · Cited by 32
Elevated nucleus accumbens structural connectivity associated with proneness to hypomania: a reward hypersensitivity perspective
Damme, K. S. F., Young, C. B., & Nusslock, R. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx017 · Cited by 35
Neonatal White Matter Microstructure and Emotional Development during the Preschool Years in Children Who Were Born Very Preterm
Kanel, D., Vanes, L. D., Pecheva, D., Hadaya, L., Falconer, S., Counsell, S. J., Edwards, A. D., & Nosarti, C. (2021) · eNeuro · doi:10.1523/eneuro.0546-20.2021 · Cited by 31

Authors: Phan, K. L., Orlichenko, A., Boyd, E., Angstadt, M., Coccaro, E. F., Liberzon, I., & Arfanakis, K.
Affiliations: University of Michigan (US)
Illinois Institute of Technology (US)
ORCID: Phan, K. Luan
Orlichenko, Anton
Angstadt, Mike
Coccaro, Emil F.
Liberzon, Israel
Arfanakis, Konstantinos
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-10
Volume: 66
Issue: 7
Pages: 691-694
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2009.02.028
PMC: PMC2743779
OpenAlex: W2049830989
Cited by: 226
References: 40
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 14 · 2021: 10 · 2020: 19 · 2019: 20 · 2018: 6 · 2017: 18 · 2016: 17 · 2015: 18 · 2014: 16 · 2013: 22 · 2012: 19
FWCI: 17.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (K23MH076198)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: generalized social anxiety disorder, uncinate fasciculus, white matter microstructure, fractional anisotropy, amygdala-prefrontal connectivity, orbitofrontal cortex, limbic system, diffusion tensor imaging
MeSH terms: Adult, Brain Mapping, Female, Frontal Lobe, Humans, Limbic System, Male, Nerve Fibers, Myelinated, Neural Pathways, Neuropsychological Tests, Phobic Disorders, Psychiatric Status Rating Scales, Case-Control Studies, Anisotropy, Diffusion Magnetic Resonance Imaging, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks