Neuroanatomical changes in a mouse model of early life neglect
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Using a novel mouse model of early life neglect and abuse (ENA) based on maternal separation with early weaning, George et al. (BMC Neurosci 11:123, 2010) demonstrated behavioral abnormalities in adult mice, and Bordner et al. (Front Psychiatry 2(18):1-18, 2011) described concomitant changes in mRNA and protein expression. Using the same model, here we report neuroanatomical changes that include smaller brain size and abnormal inter-hemispheric asymmetry, decreases in cortical thickness, abnormalities in subcortical structures, and white matter disorganization and atrophy most severely affecting the left hemisphere. Because of the similarities between the neuroanatomical changes observed in our mouse model and those described in human survivors of ENA, this novel animal model is potentially useful for studies of human ENA too costly or cumbersome to be carried out in primates. Moreover, our current knowledge of the mouse genome makes this model particularly suited for targeted anatomical, molecular, and pharmacological experimentation not yet possible in other species.
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The left hemisphere has been specifically shown to be affected in MSEW mice.
“Placement of electrode was in the left hemisphere as this hemisphere has been specifically shown to be affected in MSEW mice (42).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [42]
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- Authors
- Duque, A., Coman, D., Carlyle, B. C., Bordner, K. A., George, E. D., Papademetris, X., Hyder, F., & Simen, A. A.
- Affiliations
- Yale University (US)
- Corresponding author
- Simen, Arthur A.
- ORCID
- Venue
- Brain Structure and Function
- Published
- 2011-10-08
- Volume
- 217
- Issue
- 2
- Pages
- 459-472
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- PMC
- PMC3664301
- OpenAlex
- W2031415513
- Cited by
- 28
- References
- 79
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (P50-AA-A06377)
- National Institute on Aging (AG030970, P01AG030004, K08AG030970)
- National Institute of Mental Health (T32 MH14276, T32MH014276)
- National Institute on Drug Abuse (DA022251, R03DA022251)
- National Institute of Neurological Disorders and Stroke (P30NS052519, R01NS014841)
- National Center for Research Resources (RR024138, KL2RR024138)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- maternal separation, early weaning, mouse model, neuroanatomical changes, brain size, hemispheric lateralization, cortical thickness, subcortical structures, brain atrophy, left hemisphere, child abuse
- MeSH terms
- Animals, Animals, Newborn, Atrophy, Behavior, Animal, Brain, Cerebral Cortex, Corpus Callosum, Maternal Deprivation, Mice, Inbred C57BL, Weaning, Models, Animal, Mice, Diffusion Tensor Imaging
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