Dopamine Type 2/3 Receptor Availability in the Striatum and Social Status in Human Volunteers
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BACKGROUND: Previous PET imaging studies in non-human primates have shown that striatal dopamine type 2/3 (D(2/3)) receptors correlate with social hierarchy in monkeys, and that dominant animals exhibit higher levels of D(2/3) receptor binding. The goal of the present study was to examine this phenomena in human subjects using Positron Emission Tomography (PET) and the radiotracer [(11)C]raclopride. METHODS: Fourteen healthy volunteers were scanned with [(11)C]raclopride to measure D(2/3) receptor binding potential. Social status was assessed using the Barratt Simplified Measure of Social Status. In addition, participants were asked to assess their level of social support using the Multidimensional Scale of Perceived Social Support (MSPSS). RESULTS: A correlation was seen between social status and dopamine D(2/3) receptors, where volunteers with the higher status had higher values for [(11)C]raclopride BP. A similar correlation was seen with the perceived social support, where higher [(11)C]raclopride BP correlated with higher scores on the MSPSS. CONCLUSIONS: The results of this study support the hypothesis that social status and social support is correlated with D(2/3) receptor binding.
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In humans, a relationship has been found between perceived social support, socioeconomic status, and the availability of dopamine D2 receptors, a biological marker of addiction vulnerability.
“In humans, a relationship has been found between perceived social support, socioeconomic status, and the availability of dopamine D2 receptors [72,73], a biological marker of addiction vulnerability.”
From Addiction as a brain disease revised: why it still matters, and the need for consilience (2021) · cites this paper as [72]
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- Authors
- Martinez, D., Orlowska, D., Narendran, R., Slifstein, M., Liu, F., Kumar, D., Broft, A., Van Heertum, R., & Kleber, H. D.
- Affiliations
- Columbia University (US)
- University of Pittsburgh (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 67
- Issue
- 3
- Pages
- 275-278
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2812584
- OpenAlex
- W1969593376
- Cited by
- 146
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 13
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Public Health Service (R01DA016788, R01DA020855)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- dopamine D2/D3 receptors, striatum, social status, social hierarchy, perceived social support, receptor binding potential, human volunteers, social dominance
- MeSH terms
- Adult, Binding, Competitive, Corpus Striatum, Female, Hierarchy, Social, Humans, Magnetic Resonance Imaging, Male, Protein Binding, Statistics as Topic, Receptors, Dopamine D2, Raclopride, Positron-Emission Tomography, Receptors, Dopamine D3
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