The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
A Genomewide Association Study of Citalopram Response in Major Depressive Disorder
Open accessAbstract
Background Antidepressant response is likely influenced by genetic constitution, but the actual genes involved have yet to be determined. We have carried out a genome-wide association study to determine if common DNA variation influences antidepressant response. Methods Our sample is derived from Level 1 participants in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, all treated with citalopram. Association for the response phenotype included 883 responders and 608 non- responders. For the remission phenotype, 743 subjects that achieved remission were compared to 608 non-responders. We used a subset of SNPs (n = 430,198) from the Affymetrix 500K and 5.0 Human SNP Arrays, and association analysis was carried out after correcting for population stratification. Results We identified three SNPs associated with response with p-values less than 1 × 10−5 near the UBE3C gene (rs6966038, p = 4.65 × 10−7), another 100kb away from BMP7 (rs6127921, p = 3.45 × 10−6), and a third that is intronic in the RORA gene (rs809736, p = 8.19 × 10−6). These same SNPs were also associated with remission. Thirty-nine additional SNPs are of interest with p-values ≤ 0.0001 for the response and remission phenotypes. Conclusions Although the findings reported here do not meet a genome-wide threshold for significance, the regions identified from this study provide targets for independent replication and novel pathways to investigate mechanisms of antidepressant response. This study was not placebo controlled, making it possible that we are also observing associations to non-specific aspects of drug treatment of depression.
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PLINK: a tool set for whole-genome association and population-based linkage analyses.
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Principal components analysis corrects for stratification in genome-wide association studies
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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
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Mop3 is an essential component of the master circadian pacemaker in mammals.
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Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
Huang, J., Perlis, R. H., Lee, P. H., Rush, A. J., Fava, M., Sachs, G. S., Lieberman, J., Hamilton, S. P., Sullivan, P., Sklar, P., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091335 · Cited by 213
Self-citationGadad, B. S., Jha, M. K., Czysz, A., Furman, J. L., Mayes, T. L., Emslie, M. P., & Trivedi, M. H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.001 · Cited by 205
Cellular Circadian Clocks in Mood Disorders
McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203
Metadata
- Authors
- Garriock, H. A., Kraft, J. B., Shyn, S. I., Peters, E. J., Yokoyama, J. S., Jenkins, G. D., Reinalda, M. S., Slager, S. L., McGrath, P. J., & Hamilton, S. P.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 67
- Issue
- 2
- Pages
- 133-138
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2059483509
- Cited by
- 288
- References
- 49
- FWCI
- 16.04
- Type
- journal article
- Language
- en
- Open access
- green
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