Cited by 288Posttraumatic Stress Disorder ResearchStress Responses and CortisolAntioxidant Activity and Oxidative Stress

Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis

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Miller, M W, Sadeh, N·2014·Molecular Psychiatry

Abstract

Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellular aging. We provide an overview of empirical studies that have examined the effects of psychological stress on OXS, discuss the stress-perpetuating characteristics of PTSD, and then identify mechanisms by which PTSD might promote OXS and accelerated aging. We review studies on OXS-related genes and the role that they may have in moderating the effects of PTSD on neural integrity and conclude with a discussion of directions for future research on antioxidant treatments and biomarkers of accelerated aging in PTSD.

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Crossref · 10.1038/mp.2014.111

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  • Environmental and external stress can lead to psychological stress and subsequent cellular stress exacerbated by inflammation and oxidative damage.

    “Environmental and external stress can lead to psychological stress and the subsequent cellular stress exacerbated by inflammation and oxidative damage [553–555].”

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Authors
Miller, M. W., & Sadeh, N.
Affiliations
Boston University (US)
Corresponding author
Miller, M W
Venue
Molecular Psychiatry
Published
2014-09-23
Volume
19
Issue
11
Pages
1156-1162
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W1995994555
Cited by
288
References
136
Citations by year
2026: 15 · 2025: 29 · 2024: 27 · 2023: 25 · 2022: 28 · 2021: 25 · 2020: 25 · 2019: 24 · 2018: 26 · 2017: 25 · 2016: 23 · 2015: 15 · 2014: 1
FWCI
3.25
Type
journal article
Language
en
Open access
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs (I01 BX002150)
  • National Institute of Mental Health (R21MH102834)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
post-traumatic stress disorder, traumatic stress, oxidative stress, accelerated aging, neurodegeneration, psychological stress, cellular aging, antioxidant treatment, aging biomarkers, age-related diseases, neural integrity, oxidative stress genes
MeSH terms
Aging, Animals, Chronic Disease, Humans, Nerve Degeneration, Stress Disorders, Post-Traumatic, Stress, Psychological, Oxidative Stress

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