Cited by 194Bipolar Disorder and TreatmentFunctional Brain Connectivity StudiesNeural and Behavioral Psychology Studies

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Abnormal Left and Right Amygdala-Orbitofrontal Cortical Functional Connectivity to Emotional Faces: State Versus Trait Vulnerability Markers of Depression in Bipolar Disorder

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Versace, Amelia, Thompson, Wesley K., Zhou, Donli, Almeida, Jorge R.C., Hassel, Stefanie, Klein, Crystal R., Kupfer, David J., Phillips, Mary L.·2010·Biological Psychiatry

DOI 10.1016/j.biopsych.2009.11.025PMC PMC2835157

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Abstract

Background Amygdala-orbitofrontal cortical (OFC) functional connectivity (FC) to emotional stimuli and relationships with white matter remain little examined in bipolar disorder individuals (BD).Methods Thirty-one BD (type I; n = 17 remitted; n = 14 depressed) and 24 age- and gender-ratio-matched healthy individuals (HC) viewed neutral, mild, and intense happy or sad emotional faces in two experiments. The FC was computed as linear and nonlinear dependence measures between amygdala and OFC time series. Effects of group, laterality, and emotion intensity upon amygdala-OFC FC and amygdala-OFC FC white matter fractional anisotropy (FA) relationships were examined.Results The BD versus HC showed significantly greater right amygdala-OFC FC (p < or = .001) in the sad experiment and significantly reduced bilateral amygdala-OFC FC (p = .007) in the happy experiment. Depressed but not remitted female BD versus female HC showed significantly greater left amygdala-OFC FC (p = .001) to all faces in the sad experiment and reduced bilateral amygdala-OFC FC to intense happy faces (p = .01). There was a significant nonlinear relationship (p = .001) between left amygdala-OFC FC to sad faces and FA in HC. In BD, antidepressants were associated with significantly reduced left amygdala-OFC FC to mild sad faces (p = .001).Conclusions In BD, abnormally elevated right amygdala-OFC FC to sad stimuli might represent a trait vulnerability for depression, whereas abnormally elevated left amygdala-OFC FC to sad stimuli and abnormally reduced amygdala-OFC FC to intense happy stimuli might represent a depression state marker. Abnormal FC measures might normalize with antidepressant medications in BD. Nonlinear amygdala-OFC FC-FA relationships in BD and HC require further study.

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Authors: Versace, A., Thompson, W. K., Zhou, D., Almeida, J. R. C., Hassel, S., Klein, C. R., Kupfer, D. J., & Phillips, M. L.
Affiliations: University of Pittsburgh (US)
Corresponding author: Phillips, Mary L.
ORCID: Versace, Amelia
Thompson, Wesley K.
Almeida, Jorge R.C.
Hassel, Stefanie
Kupfer, David J.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2010-03
Volume: 67
Issue: 5
Pages: 422-431
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2009.11.025
PMC: PMC2835157
OpenAlex: W2087664470
Cited by: 194
References: 59
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 25 · 2020: 4 · 2019: 7 · 2018: 17 · 2017: 14 · 2016: 14 · 2015: 11 · 2014: 26 · 2013: 17 · 2012: 24
FWCI: 12.68
Type: journal article
Language: en
Open access: green
publications.aston.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
Aston Publications Explorer (Aston University) (acceptedVersion)
PubMed Central (acceptedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Institutes of Health (1 R01 MH076971-01, K25 MH076981-01)
National Alliance for Research on Schizophrenia and Depression Independent Investigator Award (Nellie Blumenthal Investigator)
National Science Foundation (DMS-0806106)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-Brazil (190105-2)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: bipolar disorder, emotional facial expressions, depression vulnerability, hemispheric lateralization, white matter fractional anisotropy, antidepressant effects
MeSH terms: Adult, Affect, Amygdala, Bipolar Disorder, Major Depressive Disorder, Depressive Disorder, Major, Diagnosis, Differential, Face, Facial Expression, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Nerve Net, Surveys and Questionnaires, Anisotropy, Prefrontal Cortex, Diagnostic and Statistical Manual of Mental Disorders

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Abnormal Left and Right Amygdala-Orbitofrontal Cortical Functional Connectivity to Emotional Faces: State Versus Trait Vulnerability Markers of Depression in Bipolar Disorder

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