Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study
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Mahon K, Burdick KE, Wu J, Ardekani BA, Szeszko PR. Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study. Bipolar Disord 2012: 14: 80–89. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Background: Impulsivity is characteristic of individuals with bipolar disorder and may be a contributing factor to the high rate of suicide in patients with this disorder. Although white matter abnormalities have been implicated in the pathophysiology of bipolar disorder, their relationship to impulsivity and suicidality in this disorder has not been well‐investigated. Methods: Diffusion tensor imaging scans were acquired in 14 bipolar disorder patients with a prior suicide attempt, 15 bipolar disorder patients with no prior suicide attempt, and 15 healthy volunteers. Bipolar disorder patients received clinical assessments including measures of impulsivity, depression, mania, and anxiety. Images were processed using the Tract‐Based Spatial Statistics method in the FSL software package. Results: Bipolar disorder patients with a prior suicide attempt had lower fractional anisotropy (FA) within the left orbital frontal white matter (p < 0.05, corrected) and higher overall impulsivity compared to patients without a previous suicide attempt. Among patients with a prior suicide attempt, FA in the orbital frontal white matter region correlated inversely with motor impulsivity. Conclusions: Abnormal orbital frontal white matter may play a role in impulsive and suicidal behavior among patients with bipolar disorder.
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Lower frontal-subcortical fractional anisotropy may indicate impaired top-down executive control, explaining correlations with attempt-related impulsivity and number of suicide attempts.
“Such findings may indicate impaired top-down executive control, explaining a correlation with attempt-related impulsivity (80) and number of suicide attempts (81, 82).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [80]
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A diffusion tensor imaging study of suicide attempters
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Neural substrates of suicide and suicidal behaviour: From a neuroimaging perspective
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Reduced lateral orbitofrontal cortex volume and suicide behavior in youth with bipolar disorder
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- Authors
- Mahon, K., Burdick, K. E., Wu, J., Ardekani, B. A., & Szeszko, P. R.
- Affiliations
- Northwell Health (US)
- Icahn School of Medicine at Mount Sinai (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Szeszko, Philip R
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2012-02
- Volume
- 14
- Issue
- 1
- Pages
- 80-89
- ISSN
- 1398-5647 (ISSN-L)
- 1399-5618
- PMC
- PMC3319758
- OpenAlex
- W2153199664
- Cited by
- 131
- References
- 80
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 27 · 2017: 7 · 2016: 9 · 2015: 16 · 2014: 22 · 2013: 3
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Bipolar Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R03MH079995)
- National Center for Research Resources (M01RR018535)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Keywords
- bipolar I disorder, suicidality, impulsivity, motor impulsivity, white matter abnormalities, fractional anisotropy, suicide attempts, tract-based spatial statistics
- MeSH terms
- Adult, Bipolar Disorder, Female, Frontal Lobe, Humans, Impulsive Behavior, Male, Middle Aged, Nerve Fibers, Myelinated, Suicide, Attempted, Case-Control Studies, Diffusion Tensor Imaging
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