Cited by 153Smoking Behavior and CessationNeurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

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Granular Insular Cortex Inactivation as a Novel Therapeutic Strategy for Nicotine Addiction

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Forget, Benoit, Pushparaj, Abhiram, Le Foll, Bernard·2010·Biological Psychiatry

DOI 10.1016/j.biopsych.2010.01.029

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Abstract

Background Nicotine is the principal component of tobacco smoke, resulting in addiction, and recent evidence suggests that damage to the insular cortex (insula) disrupts tobacco addiction in human smokers. However, the effect of an inactivation of this structure in an animal model of nicotine addiction has yet to be evaluated. Methods To study this question, we investigated the effects of reversible inactivation of the granular insula by local injection of a gamma-aminobutyric acid agonists mixture (baclofen/muscimol) on nicotine self-administration (SA) under fixed and progressive ratio and on reinstatement of nicotine seeking induced by nicotine priming or nicotine-associated cues in rats. We also evaluated the effects of granular insula inactivation on food SA and relapse as a control. Results The inactivation of the granular insula decreased nicotine SA under both fixed and progressive ratios without affecting the SA of food under the same schedules of reinforcement. This inactivation also prevented the reinstatement, after extinction, of nicotine seeking induced by nicotine-associated cues or nicotine priming without modifying the reinstatement of food seeking. Conclusions Our study indicates that the integrity of the granular insula is necessary for exhibiting motivation to take nicotine and to relapse to nicotine seeking but not for consuming food pellets or to relapse for food seeking. Indeed, it might be interesting to study the effect of methods that are able to modulate the activity of the insula--such as repetitive transcranial magnetic stimulation or deep brain stimulation--on tobacco addiction and relapse in humans.

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The rat brain in stereotaxic coordinates
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Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Subcortical and cortical brain activity during the feeling of self-generated emotions
Damasio, A. R., Grabowski, T. J., Bechara, A., Damasio, H., Ponto, L. L. B., Parvizi, J., & Hichwa, R. D. (2000) · Nature Neuroscience · doi:10.1038/79871 · Cited by 2,117
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615
An Insular View of Anxiety
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A role for lateral hypothalamic orexin neurons in reward seeking
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Damage to the insula disrupts addiction to cigarette smoking
Naqvi, N. H., Rudrauf, D., Damasio, H., & Bechara, A. (2007) · Science · doi:10.1126/science.1135926 · Cited by 1,245
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
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The hidden island of addiction: the insula
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Show all 58 references

Research works printed but not linked: 1

Shi, 1998, Cortical, thalamic, and amygdaloid connections of the anterior and posterior insular cortices, J Comp Neurol, 399, 440, 10.1002/(SICI)1096-9861(19981005)399:4<440::AID-CNE2>3.0.CO;2-1 · DOI

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Do, K. T., & Galván, A. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv038 · Cited by 22
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Authors: Forget, B., Pushparaj, A., & Le Foll, B.
Affiliations: University of Toronto (CA)
ORCID: Pushparaj, Abhiram
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2010-08
Volume: 68
Issue: 3
Pages: 265-271
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2010.01.029
OpenAlex: W2035027501
Cited by: 153
References: 58
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 17 · 2014: 7 · 2013: 14 · 2012: 13
FWCI: 8.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Ontario Ministry of Research, Innovation and Science
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: nicotine dependence, insula, neural inactivation, nicotine self-administration, relapse, food self-administration, motivation
MeSH terms: Analysis of Variance, Animals, Association Learning, Baclofen, Behavior, Animal, Cerebral Cortex, Conditioning, Classical, Disease Models, Animal, Drug Combinations, Extinction, Psychological, Male, Microinjections, Motivation, Muscimol, Nicotine, Reinforcement Schedule, Self Administration, Tobacco Use Disorder, Behavior, Addictive, Nicotinic Agonists, GABA Agonists, Rats

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Granular Insular Cortex Inactivation as a Novel Therapeutic Strategy for Nicotine Addiction

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