Memory retrieval of smoking‐related images induce greater insula activation as revealed by an fMRI‐based delayed matching to sample task
Open accessAbstract
Nicotine dependence is a chronic and difficult to treat disorder. While environmental stimuli associated with smoking precipitate craving and relapse, it is unknown whether smoking cues are cognitively processed differently than neutral stimuli. To evaluate working memory differences between smoking-related and neutral stimuli, we conducted a delay-match-to-sample (DMS) task concurrently with functional magnetic resonance imaging (fMRI) in nicotine-dependent participants. The DMS task evaluates brain activation during the encoding, maintenance and retrieval phases of working memory. Smoking images induced significantly more subjective craving, and greater midline cortical activation during encoding in comparison to neutral stimuli that were similar in content yet lacked a smoking component. The insula, which is involved in maintaining nicotine dependence, was active during the successful retrieval of previously viewed smoking versus neutral images. In contrast, neutral images required more prefrontal cortex-mediated active maintenance during the maintenance period. These findings indicate that distinct brain regions are involved in the different phases of working memory for smoking-related versus neutral images. Importantly, the results implicate the insula in the retrieval of smoking-related stimuli, which is relevant given the insula's emerging role in addiction.
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Smokers who participated in a memory retrieval task involving smoking and neutral cues had the left insula significantly more active during the retrieval of smoking cues compared to neutral cues.
“Smokers who participated in a memory retrieval task involving smoking and neutral cues were found to have the left insula significantly more active during the retrieval of smoking cues compared to neutral cues.”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Janes et al., 2015
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The Insula: A Brain Stimulation Target for the Treatment of Addiction
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- Authors
- Janes, A. C., Ross, R. S., Farmer, S., Frederick, B. B., Nickerson, L. D., Lukas, S. E., & Stern, C. E.
- Affiliations
- Harvard University (US)
- Boston University (US)
- Corresponding author
- Janes, Amy C.
- ORCID
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2013-11-22
- Volume
- 20
- Issue
- 2
- Pages
- 349-356
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- PMC
- PMC4031308
- OpenAlex
- W1943696030
- Cited by
- 28
- References
- 52
- Citations by year
- 2023: 3 · 2021: 5 · 2020: 2 · 2019: 5 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 2
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of New Hampshire Scholars Repository (University of New Hampshire at Manchester) (submittedVersion)
- Funders
- National Institute on Drug Abuse (DA029645)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine dependence, smoking cues, working memory, memory retrieval, insula, craving, prefrontal cortex, memory maintenance
- MeSH terms
- Adolescent, Adult, Cerebral Cortex, Cues, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Memory, Short-Term, Photic Stimulation, Smoking, Tobacco Use Disorder, Prefrontal Cortex, Young Adult, Functional Neuroimaging, Craving
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