The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Angiotensin Type 1 Receptor Inhibition Enhances the Extinction of Fear Memory
Open accessAbstract
Background The current effective treatment options for posttraumatic stress disorder (PTSD) are limited, and therefore the need to explore new treatment strategies is critical. Pharmacological inhibition of the renin-angiotensin system is a common approach to treat hypertension, and emerging evidence highlights the importance of this pathway in stress and anxiety. A recent clinical study from our laboratory provides evidence supporting a role for the renin-angiotensin system in the regulation of the stress response in patients diagnosed with PTSD.Methods With an animal model of PTSD and the selective angiotensin receptor type 1 (AT1) antagonist losartan, we investigated the acute and long-term effects of AT1 receptor inhibition on fear memory and baseline anxiety. After losartan treatment, we performed classical Pavlovian fear conditioning pairing auditory cues with footshocks and examined extinction behavior, gene expression changes in the brain, as well as neuroendocrine and cardiovascular responses.Results After cued fear conditioning, both acute and 2-week administration of losartan enhanced the consolidation of extinction memory but had no effect on fear acquisition, baseline anxiety, blood pressure, and neuroendocrine stress measures. Gene expression changes in the brain were also altered in mice treated with losartan for 2 weeks, in particular reduced amygdala AT1 receptor and bed nucleus of the stria terminalis c-Fos messenger RNA levels.Conclusions These data suggest that AT1 receptor antagonism enhances the extinction of fear memory and therefore might be a beneficial therapy for PTSD patients who have impairments in extinction of aversive memories.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, recent evidence from mouse studies implicates the renin–angiotensin system in the regulation of fear and anxiety responses as angiotensin receptor AT1 antagonism with the anti-hypertension drug losartan has been shown to enhance fear extinction learning [extinction recall; (87)].”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [87]
In the citing paper
“In addition, recent evidence from mouse studies implicates the renin–angiotensin system in the regulation of fear and anxiety responses as angiotensin receptor AT1 antagonism with the anti-hypertension drug losartan has been shown to enhance fear extinction learning [extinction recall; (87)].”
From Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors (2014) · cites this paper as [87]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Trauma and Posttraumatic Stress Disorder in the Community: The 1996 Detroit Area Survey of Trauma
Breslau, N., Kessler, R. C., Chilcoat, H. D., Schultz, L. R., Davis, G. C., & Andreski, P. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.626 · Cited by 2,407
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., et al. (2011) · Nature · doi:10.1038/nature09856 · Cited by 800
Self-citationHeldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684
Self-citationMahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 643
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Wright, 2008, The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer’s disease, J Renin Angiotensin Aldosterone Syst, 9, 226, 10.1177/1470320308099084 · DOI
Cited by
Sorted by citations
Items 101–109 of 109
Zhou, X., Xu, T., Zeng, Y., Zhang, R., Qi, Z., Zhao, W., Kendrick, K. M., & Becker, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.19.452920 · Cited by 2
Xu, T., Chen, Z., Zhou, X., Wang, L., Zhou, F., Yao, D., Zhou, B., & Becker, B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.20.533428 · Cited by 1
Disgust: Internal Context Matters
Garfinkel, S. N. (2021) · Current Biology · doi:10.1016/j.cub.2020.11.057
Zhou, X., Xu, T., Zeng, Y., Zhang, R., Qi, Z., Zhao, W., Kendrick, K. M., & Becker, B. (2021) · doi:10.22541/au.163251473.31756493/v1
USO DE ANTI-HIPERTENSIVOS NA MODULAÇÃO DA ANSIEDADE EM MODELOS ANIMAIS
ALVES, L. B. D. S. (2021) · doi:10.17771/pucrio.acad.53170
Zika, O., Appel, J. E., Klinge, C., Shkreli, L., Browning, M. D., Wiech, K., & Reinecke, A. (2023) · doi:10.31234/osf.io/e5wdv
Tracking conditioned fear in pair-housed mice using deep learning and real-time cue delivery
Smith, H. C., Yu, Z., Yazigi, P., Turley, B., Swiercz, A. P., Park, J., & Marvar, P. J. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100742
Self-citationTimoshina, Y. A., Deinekina, T. S., Савинкова, Е. В., Yudin, V. S., Keskinov, A. A., Makarov, V. V., & Anderzhanova, E. A. (2025) · Extreme Medicine · doi:10.47183/mes.2025-321
The role of renin-angiotensin system modulation in the pathophysiology of neuropsychiatric disorders
Sharma, A., Goel, T., Mannan, A., Subramaniyan, V., & Singh, T. G. (2026) · Hormones and Behavior · doi:10.1016/j.yhbeh.2026.106003
Metadata
- Authors
- Marvar, P. J., Goodman, J., Fuchs, S., Choi, D. C., Banerjee, S., & Ressler, K. J.
- Affiliations
- Emory University (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 75
- Issue
- 11
- Pages
- 864-872
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3975818
- OpenAlex
- W2053674362
- Cited by
- 110
- References
- 82
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 4 · 2019: 19 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 11 · 2014: 7
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (P51OD011132)
- National Heart, Lung, and Blood Institute (K99HL107675, R00HL107675)
- National Institute of Mental Health (R01MH096764)
- National Center for Research Resources (P51RR000165)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- angiotensin II type 1 receptor, losartan, fear extinction, post-traumatic stress disorder, renin-angiotensin system, fear conditioning, amygdala, bed nucleus of the stria terminalis, c-fos, anxiety, stress response, cardiovascular response, neuroendocrine response
- MeSH terms
- Animals, Disease Models, Animal, Extinction, Psychological, Fear, Male, Memory, Mice, Inbred C57BL, Stress Disorders, Post-Traumatic, Losartan, Angiotensin II Type 1 Receptor Blockers, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
