Cited by 110Memory and Neural MechanismsPosttraumatic Stress Disorder ResearchRenin-Angiotensin System Studies

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Angiotensin Type 1 Receptor Inhibition Enhances the Extinction of Fear Memory

Open access

Marvar, Paul J., Goodman, Jared, Fuchs, Sebastien, Choi, Dennis C., Banerjee, Sunayana, Ressler, Kerry J.·2014·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.08.024PMC PMC3975818

Open this paper in CoChat — free account

Abstract

Background The current effective treatment options for posttraumatic stress disorder (PTSD) are limited, and therefore the need to explore new treatment strategies is critical. Pharmacological inhibition of the renin-angiotensin system is a common approach to treat hypertension, and emerging evidence highlights the importance of this pathway in stress and anxiety. A recent clinical study from our laboratory provides evidence supporting a role for the renin-angiotensin system in the regulation of the stress response in patients diagnosed with PTSD.Methods With an animal model of PTSD and the selective angiotensin receptor type 1 (AT1) antagonist losartan, we investigated the acute and long-term effects of AT1 receptor inhibition on fear memory and baseline anxiety. After losartan treatment, we performed classical Pavlovian fear conditioning pairing auditory cues with footshocks and examined extinction behavior, gene expression changes in the brain, as well as neuroendocrine and cardiovascular responses.Results After cued fear conditioning, both acute and 2-week administration of losartan enhanced the consolidation of extinction memory but had no effect on fear acquisition, baseline anxiety, blood pressure, and neuroendocrine stress measures. Gene expression changes in the brain were also altered in mice treated with losartan for 2 weeks, in particular reduced amygdala AT1 receptor and bed nucleus of the stria terminalis c-Fos messenger RNA levels.Conclusions These data suggest that AT1 receptor antagonism enhances the extinction of fear memory and therefore might be a beneficial therapy for PTSD patients who have impairments in extinction of aversive memories.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2013.08.024

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822
Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Trauma and Posttraumatic Stress Disorder in the Community: The 1996 Detroit Area Survey of Trauma
Breslau, N., Kessler, R. C., Chilcoat, H. D., Schultz, L. R., Davis, G. C., & Andreski, P. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.626 · Cited by 2,407
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., et al. (2011) · Nature · doi:10.1038/nature09856 · Cited by 800
Self-citation
Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684
Self-citation
Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder
Mahan, A. L., & Ressler, K. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.007 · Cited by 643
Self-citation

Flagged first, then by citations

Show all 82 references

Research works printed but not linked: 1

Wright, 2008, The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer’s disease, J Renin Angiotensin Aldosterone Syst, 9, 226, 10.1177/1470320308099084 · DOI

Sorted by citations

The Lancet Psychiatry Commission on psychological treatments research in tomorrow's science
Holmes, E. A., Ghaderi, A., Harmer, C. J., Ramchandani, P. G., Cuijpers, P., Morrison, A. P., Roiser, J. P., Bockting, C. L. H., O'Connor, R. C., Shafran, R., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30513-8 · Cited by 624
State-of-the-art and future directions for extinction as a translational model for fear and anxiety
Craske, M. G., Hermans, D., & Vervliet, B. (2018) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2017.0025 · Cited by 373
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
Stein, M. B., Levey, D. F., Cheng, Z., Wendt, F. R., Harrington, K. M., Pathak, G. A., Cho, K., Quaden, R. M., Radhakrishnan, K., Girgenti, M. J., et al. (2021) · Nature Genetics · doi:10.1038/s41588-020-00767-x · Cited by 239
Neuroprotective Effects of Angiotensin Receptor Blockers
Villapol, S., & Saavedra, J. M. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu197 · Cited by 219
Interoceptive pathways to understand and treat mental health conditions
Nord, C. L., & Garfinkel, S. N. (2022) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2022.03.004 · Cited by 199
Posttraumatic stress disorder: A metabolic disorder in disguise?
Michopoulos, V., Vester, A., & Neigh, G. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.038 · Cited by 152
Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease
Brudey, C., Park, J., Wiaderkiewicz, J., Kobayashi, I., Mellman, T. A., & Marvar, P. J. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00343.2014 · Cited by 137
Self-citation
The Physiology of Fear: Reconceptualizing the Role of the Central Amygdala in Fear Learning
Keifer, O. P., Hurt, R. C., Ressler, K. J., & Marvar, P. J. (2015) · Physiology · doi:10.1152/physiol.00058.2014 · Cited by 124
Self-citation
Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors
Briscione, M. A., Jovanovic, T., & Norrholm, S. D. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00088 · Cited by 105
Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors
Wang, L. A., de Kloet, A. D., Pati, D., Hiller, H., Smith, J. A., Pioquinto, D. J., Ludin, J. A., Oh, S. P., Katovich, M. J., Frazier, C. J., et al. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.026 · Cited by 105
FROM THE NEUROBIOLOGY OF EXTINCTION TO IMPROVED CLINICAL TREATMENTS
Morrison, F. G., & Ressler, K. J. (2013) · Depression and Anxiety · doi:10.1002/da.22214 · Cited by 107
Self-citation
Augmentation of Extinction and Inhibitory Learning in Anxiety and Trauma-Related Disorders
Lebois, L. A. M., Seligowski, A. V., Wolff, J. D., Hill, S. B., & Ressler, K. J. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095634 · Cited by 97
Self-citation
A Unique “Angiotensin-Sensitive” Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress
de Kloet, A. D., Wang, L. A., Pitra, S., Hiller, H., Smith, J. A., Tan, Y., Nguyen, D., Cahill, K. M., Sumners, C., Stern, J. E., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3674-16.2017 · Cited by 90
Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity
Jaimes, R., Swiercz, A. P., Sherman, M. G., Muselimyan, N., Marvar, P. J., & Posnack, N. G. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00364.2017 · Cited by 88
Self-citation
Beneficial effects of Angiotensin II receptor blockers in brain disorders
Saavedra, J. M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.06.017 · Cited by 81
Human Extinction Learning Is Accelerated by an Angiotensin Antagonist via Ventromedial Prefrontal Cortex and Its Connections With Basolateral Amygdala
Zhou, F., Geng, Y., Xin, F., Li, J., Feng, P., Liu, C., Zhao, W., Feng, T., Guastella, A. J., Ebstein, R. P., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.007 · Cited by 70
Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders
Bukalo, O., Pinard, C. R., & Holmes, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12779 · Cited by 73
Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system
Quitterer, U., & AbdAlla, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.014 · Cited by 67
Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation
Salmani, H., Hosseini, M., Baghcheghi, Y., Moradi‐Marjaneh, R., & Mokhtari‐Zaer, A. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154860 · Cited by 53
Involvement of the brain–heart axis in the link between PTSD and cardiovascular disease
Seligowski, A. V., Webber, T. K., Marvar, P. J., Ressler, K. J., & Philip, N. S. (2022) · Depression and Anxiety · doi:10.1002/da.23271 · Cited by 55
Self-citation
The renin–angiotensin system in PTSD: a replication and extension
Seligowski, A. V., Duffy, L., Merker, J. B., Michopoulos, V., Gillespie, C. F., Marvar, P. J., Stein, M. B., & Ressler, K. J. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00923-1 · Cited by 52
Self-citation
The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases
Wright, J. W., Kawas, L. H., & Harding, J. W. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.11.004 · Cited by 51
An angiotensin‐converting enzyme (ACE) polymorphism may mitigate the effects of angiotensin‐pathway medications on posttraumatic stress symptoms
Nylocks, K. M., Michopoulos, V., Rothbaum, A. O., Almli, L. M., Gillespie, C. F., Wingo, A. P., Schwartz, A. C., Habib, L., Gamwell, K. L., Marvar, P. J., et al. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32313 · Cited by 51
Self-citation
Estradiol modulation of the renin–angiotensin system and the regulation of fear extinction
Parrish, J. N., Bertholomey, M. L., Pang, H. W., Speth, R. C., & Torregrossa, M. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0374-0 · Cited by 51
Should losartan be administered following brain injury?
Friedman, A., Bar-Klein, G., Serlin, Y., Parmet, Y., Heinemann, U., & Kaufer, D. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.972945 · Cited by 47
The Effects of the Angiotensin II Receptor Antagonist Losartan on Appetitive Versus Aversive Learning: A Randomized Controlled Trial
Pulcu, E., Shkreli, L., Holst, C. G., Woud, M. L., Craske, M. G., Browning, M. D., & Reinecke, A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.010 · Cited by 46
How can neurobiology of fear extinction inform treatment?
Craske, M. G., Sandman, C. F., & Stein, M. B. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104923 · Cited by 43
Brain angiotensin-(1–7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress
Fontes, M. A. P., Lima, A. M., & Santos, R. A. S. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.10.003 · Cited by 41
Amygdala-Dependent Molecular Mechanisms of the Tac2 Pathway in Fear Learning
Andero, R., Daniel, S., Guo, J., Bruner, R. C., Seth, S., Marvar, P. J., Rainnie, D. G., & Ressler, K. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.77 · Cited by 41
Self-citation
Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy
Seligowski, A. V., Misganaw, B., Duffy, L., Ressler, K. J., & Guffanti, G. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21111113 · Cited by 42
Self-citation
The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease
Wright, J. W., & Harding, J. W. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142814 · Cited by 40
Associations of trauma exposure and post-traumatic stress disorder with the activity of the renin–angiotensin–aldosterone-system in the general population
Terock, J., Hannemann, A., Janowitz, D., Freyberger, H. J., Felix, S. B., Dörr, M., Nauck, M. A., Völzke, H., & Grabe, H. J. (2018) · Psychological Medicine · doi:10.1017/s0033291718001496 · Cited by 41
Endocrine‐Autonomic Linkages
Sladek, C. D., Michelini, L. C., Stachenfeld, N. S., Stern, J. E., & Urban, J. H. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140028 · Cited by 51
Angiotensin type 1a receptors on corticotropin‐releasing factor neurons contribute to the expression of conditioned fear1
Hurt, R. C., Garrett, J. C., Keifer, O. P., Linares, A., Couling, L. E., Speth, R. C., Ressler, K. J., & Marvar, P. J. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12235 · Cited by 39
Self-citation
Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals
Reinecke, A., Browning, M. D., Breteler, J. K., Kappelmann, N., Ressler, K. J., Harmer, C. J., & Craske, M. G. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.05.007 · Cited by 35
Self-citation
Angiotensin Receptor Blockers Are Not Just for Hypertension Anymore
Saavedra, J. M. (2021) · Physiology · doi:10.1152/physiol.00036.2020 · Cited by 37
Candesartan ameliorates impaired fear extinction induced by innate immune activation
Quiñones-Cordero, M. M., Maldonado, L., Velázquez, B., & Porter, J. T. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.017 · Cited by 39
Randomized, Placebo-Controlled Trial of the Angiotensin Receptor Antagonist Losartan for Posttraumatic Stress Disorder
Stein, M. B., Jain, S., Simon, N. M., West, J. C., Marvar, P. J., Bui, É., He, F., Benedek, D. M., Cassano, P., Griffith, J. L., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.012 · Cited by 38
Self-citation
Angiotensin II Type 2 Receptor–Expressing Neurons in the Central Amygdala Influence Fear-Related Behavior
Yu, Z., Swiercz, A. P., Moshfegh, C. M., Hopkins, L. S., Wiaderkiewicz, J., Speth, R. C., Park, J., & Marvar, P. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.027 · Cited by 32
Self-citation
Limbic Neuropeptidergic Modulators of Emotion and Their Therapeutic Potential for Anxiety and Post-Traumatic Stress Disorder
Marvar, P. J., Andero, R., Hurlemann, R., Lago, T. R., Zelikowsky, M., & Dabrowska, J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1647-20.2020 · Cited by 29
Self-citation
Pharmacological strategies for post-traumatic stress disorder (PTSD): From animal to clinical studies
Gasparyan, A., Navarro, D., Navarrete, F., & Manzanares, J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109211 · Cited by 34
Involvement of the Renin-Angiotensin System in Stress: State of the Art and Research Perspectives
Correa, B. H. M., Becari, L., Fontes, M. A. P., Silva, A. C. S. E., & Kangussu, L. M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210719142300 · Cited by 31
Angiotensin involvement in trauma processing—exploring candidate neurocognitive mechanisms of preventing post-traumatic stress symptoms
Shkreli, L., Woud, M. L., Ramsbottom, R., Rupietta, A. E., Waldhauser, G. T., Kumsta, R., & Reinecke, A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0553-y · Cited by 28
Differential activation of the renin-angiotensin-aldosterone-system in response to childhood and adulthood trauma
Terock, J., Hannemann, A., Janowitz, D., der Auwera, S. V., Bahls, M., Völzke, H., & Grabe, H. J. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.026 · Cited by 27
Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin II AT1 Receptors Stimulation
Marinzalda, M. D. L. Á., Pérez, P. A., Gargiulo, P. Á., Casarsa, B. S., Bregonzio, C., & Baiardi, G. (2014) · BioMed Research International · doi:10.1155/2014/183248 · Cited by 26
Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways
Attilio, P. J., Snapper, D. M., Rusnak, M., Isaac, A. J., Soltis, A. R., Wilkerson, M. D., Dalgard, C. L., & Symes, A. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.636259 · Cited by 26
Molecular signaling pathways underlying schizophrenia
Tiihonen, J., Koskuvi, M., Lähteenvuo, M., Trontti, K., Ojansuu, I., Vaurio, O., Cannon, T. D., Lönnqvist, J. K., Therman, S., Suvisaari, J., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.05.011 · Cited by 25
Targeting the Renin-Angiotensin System (RAS) for Neuropsychiatric Disorders
de Miranda, A. S., Macêdo, D. S., Rocha, N. P., & Teixeira, A. L. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220927093815 · Cited by 24
Hydration and beyond: neuropeptides as mediators of hydromineral balance, anxiety and stress-responsiveness
Smith, J. A., Pati, D., Wang, L. A., de Kloet, A. D., Frazier, C. J., & Krause, E. G. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00046 · Cited by 25
Angiotensin II Regulates the Neural Expression of Subjective Fear in Humans: A Precision Pharmaco-Neuroimaging Approach
Zhang, R., Zhao, W., Qi, Z., Xu, T., Zhou, F., & Becker, B. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.09.008 · Cited by 21
Neuropsychiatric Properties of the ACE2/Ang-(1-7)/Mas Pathway: A Brief Review
de Melo, L. A., & Almeida-Santos, A. F. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191223143230 · Cited by 24
Exploring the Evidence Implicating the Renin-Angiotensin System (RAS) in the Physiopathology of Mood Disorders
Mohite, S., Sanches, M., & Teixeira, A. L. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191223144000 · Cited by 25
The Angiotensin Antagonist Losartan Modulates Social Reward Motivation and Punishment Sensitivity via Modulating Midbrain-Striato-Frontal Circuits
Zhou, X., Xu, T., Zeng, Y., Zhang, R., Qi, Z., Zhao, W., Kendrick, K. M., & Becker, B. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1114-22.2022 · Cited by 19
Angiotensin-(1-7)/Mas axis modulates fear memory and extinction in mice
Lazaroni, T. L. D. N., Bastos, C. P., Moraes, M. F. D., Santos, R. A. S., & Pereira, G. S. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.012 · Cited by 22
Evaluation of an angiotensin Type 1 receptor blocker on the reconsolidation of fear memory
Swiercz, A. P., Iyer, L., Yu, Z., Edwards, A., Prashant, N. M., Nguyen, B., Horvath, A., & Marvar, P. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01043-6 · Cited by 21
Self-citation
Oestradiol, threat conditioning and extinction, post‐traumatic stress disorder, and prolonged exposure therapy: A common link
Hammoud, M. Z., Foa, E. B., & Milad, M. R. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12800 · Cited by 23
Class A and C GPCR Dimers in Neurodegenerative Diseases
Moreira, I. S., Caniceiro, A. B., Bueschbell, B., & Schiedel, A. C. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220327221830 · Cited by 18
Angiotensin Antagonist Inhibits Preferential Negative Memory Encoding via Decreasing Hippocampus Activation and Its Coupling With the Amygdala
Xu, T., Zhou, X., Jiao, G., Zeng, Y., Zhao, W., Li, J., Yu, F., Zhou, F., Yao, S., & Becker, B. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.05.007 · Cited by 16
Overexpression of angiotensin converting enzyme 2 reduces anxiety-like behavior in female mice.
de Kloet, A. D., Cahill, K. M., Scott, K. A., & Krause, E. G. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113002 · Cited by 20
The central renin–angiotensin system: A genetic pathway, functional decoding, and selective target engagement characterization in humans
Xu, T., Chen, Z., Zhou, X., Wang, L., Zhou, F., Yao, D., Zhou, B., & Becker, B. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306936121 · Cited by 18
Pharmacotherapy for Anxiety Disorders.
O’Leary, K. B., & Khan, J. S. (2024) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2024.04.012 · Cited by 22
Trait anxiety but not state anxiety level associates with biomarkers for hypertension in the metabolic syndrome
Lemche, A. V., Чабан, О., & Lemche, E. (2016) · Psychophysiology · doi:10.1111/psyp.12623 · Cited by 18
Extinction of Fear Memory Attenuates Conditioned Cardiovascular Fear Reactivity
Swiercz, A. P., Seligowski, A. V., Park, J., & Marvar, P. J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00276 · Cited by 18
Self-citation
Central amygdala angiotensin type 1 receptor (Agtr1) expressing neurons contribute to fear extinction
Yu, Z., Kisner, A., Bhatt, A., Polter, A. M., & Marvar, P. J. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109460 · Cited by 17
Self-citation
Pharmacological rewriting of fear memories: A beacon for post-traumatic stress disorder
Uniyal, A., Singh, R., Akhtar, A., Dhaliwal, J., Kuhad, A., & Sah, S. P. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172824 · Cited by 19
Honoring the Past, Envisioning the Future: ABCT’s 50th Anniversary Presidential Address
Craske, M. G. (2017) · Behavior Therapy · doi:10.1016/j.beth.2017.05.003 · Cited by 18
PTSD as an Endothelial Disease: Insights From COVID-19
Sfera, A., Osorio, C. P., Rahman, L., del Campo, C. M. Z.-M., Maldonado, J. C., Jafri, N., Cummings, M. A., Maurer, S., & Kozlakidis, Z. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.770387 · Cited by 16
Angiotensin II Signaling and Fear Extinction: Translational Evidence and Novel Receptor Targets
Stout, D. M., & Risbrough, V. B. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.026 · Cited by 16
Angiotensin Type 1 Receptor Antagonists—A Novel Approach to Augmenting Posttraumatic Stress Disorder and Phobia Therapies?
Shekhar, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.004 · Cited by 17
Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran SamplePreprint
Stein, M. B., Levey, D. F., Cheng, Z., Wendt, F. R., Harrington, K. M., Cho, K., Quaden, R. M., Radhakrishnan, K., Girgenti, M. J., Ho, Y.-L. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/764001 · Cited by 15
Pharmacotherapy of anxiety disorders in the 21st century: A call for novel approaches
Bui, É., King, F., & Melaragno, A. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100136 · Cited by 17
Recruitment of central angiotensin II type 1 receptor associated neurocircuits in carbon dioxide associated fear
Winter, A., Ahlbrand, R., & Sah, R. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.02.007 · Cited by 14
Cardiovascular reactivity to emotional stress: The hidden challenge for pets in the urbanized environment
Silva, C. C., & Fontes, M. A. P. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.05.014 · Cited by 11
SKF83959, an agonist of phosphatidylinositol-linked dopamine receptors, prevents renewal of extinguished conditioned fear and facilitates extinction
Chen, F.-F., Wang, C., Chen, H., Wang, J., Han, Q.-Q., Cao, Y., Shen, T., Yang, Y., Hu, Z., Wang, F., et al. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147136 · Cited by 9
Enhancing Fear Extinction: Pharmacological Approaches
Ponomareva, O. Y., Fenster, R. J., & Ressler, K. J. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_443 · Cited by 7
Self-citation
Effects of Combined Anti-Hypertensive and Statin Treatment on Memory, Fear Extinction, Adult Neurogenesis, and Angiogenesis in Adult and Middle-Aged Mice
Yoo, S., Stremlau, M. H., Pinto, A., Woo, H., Curtis, O., & van Praag, H. (2021) · Cells · doi:10.3390/cells10071778 · Cited by 9
Use of renin-angiotensin system blockers and posttraumatic stress disorder risk in the UK Biobank: a retrospective cohort study
Kang, S., Kim, J., Yang, J. S., Jeon, Y. J., Lee, H., Suglia, S. F., Tsai, A. C., Kang, J. I., & Jung, S. J. (2024) · BMC Medicine · doi:10.1186/s12916-024-03704-5 · Cited by 8
Neural Circuitry of Stress, Fear, and Anxiety
Paul, E. D., & Chen, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00008-5 · Cited by 7
Reduction of Aversive Learning Rates in Pavlovian Conditioning by Angiotensin II Antagonist Losartan: A Randomized Controlled Trial
Zika, O., Appel, J. E., Klinge, C., Shkreli, L., Browning, M. D., Wiech, K., & Reinecke, A. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.01.020 · Cited by 6
Sex-dependent effects of angiotensin II type 1 receptor blocker on molecular and behavioral changes induced by single prolonged stress
Ortiz-Nazario, E., Denton-Ortiz, C. M., Soto-Escobar, L. D. M., Mateo-Mayol, Z., Colón-Romero, M., Hernández, A., & Porter, J. T. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114639 · Cited by 6
The effect of angiotensin AT1A inactivation on innate and learned fear responses in mice and its relationship to blood pressure
Choy, K. H. C., Chavez, C. A., Yu, J., & Mayorov, D. N. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.004 · Cited by 5
RNA-based drugs: current, imminent and possible therapeutic applications
Torrisi, S. A., Geraci, F., Diolosà, L., Luca, A. D., Falzone, L., Drago, F., Libra, M., & Leggio, G. M. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108958 · Cited by 9
Acute Angiotensin II Receptor Blockade Facilitates Parahippocampal Processing During Memory Encoding in High-Trait-Anxious Individuals
Shkreli, L., Thoroddsen, T., Kobelt, M., Martens, M., Browning, M. D., Harmer, C. J., Cowen, P. J., & Reinecke, A. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.100286 · Cited by 6
Failure of Losartan in a Clinical Trial for Posttraumatic Stress Disorder: Lack of Efficacy or Spotlight on the Power of Placebo?
Torregrossa, M. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.009 · Cited by 5
Stress, Angiotensin, and Cognate Receptors
Aguilera, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00024-3 · Cited by 5
Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients?
Iftikhar, A., Islam, M. R., Shepherd, S. D., Jones, S., & Ellis, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714999 · Cited by 5
Nitric oxide pathway presumably does not contribute to antianxiety and memory retrieval effects of losartan
Aghaei, I., Arjmand, S., Yousefzadeh-Chabok, S., Tondar, M., & Shabani, M. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000311 · Cited by 5
Renin-angiotensin-aldosterone system activity in a female trauma-exposed sample
Sinnott, S. M., Ellis, R. A., Khawand, A., Marvar, P. J., Stein, M. B., Ressler, K. J., Huffman, J. C., & Seligowski, A. V. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116573 · Cited by 4
Self-citation
A pressor dose of angiotensin II has no influence on the angiotensin‐converting enzyme 2 and other molecules associated with SARS‐CoV‐2 infection in mice
Wang, Y., Takeshita, H., Yamamoto, K. I., Huang, Y., Wang, C., Nakajima, T., Nozato, Y., Fujimoto, T., Yokoyama, S., Hongyo, K., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100016r · Cited by 4
The influence of chromosome 4 on high ethanol consumption and blood pressure
Anjos, P. A. R., Marchette, R. C. N., Kremer, R., Granzotto, N., Alves, T. M., Fadanni, G. P., Mazur, F. G., Anton, E. L., da Silva‐Santos, J. E., Linder, A. E., et al. (2022) · Alcohol · doi:10.1016/j.alcohol.2022.04.004 · Cited by 4
Ang II-mediated effects on BBB integrity in psychiatric and neurological disorders
Towo, D. H. H., Jari, I., Canivet, C., & Deslauriers, J. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111635 · Cited by 3
Outcomes of metabolic syndrome and anxiety levels in light and heavy smokers
Şahin, M., & Yüzügüllü, D. (2025) · PeerJ · doi:10.7717/peerj.19069 · Cited by 5
Antihypertensive Medications and PTSD Incidence in a Trauma Cohort
Gradus, J. L., Smith, M. L., Szentkúti, P., Rosellini, A. J., Horváth–Puhó, E., Lash, T. L., Galea, S., Schnurr, P. P., Sumner, J. A., & Sørensen, H. T. (2023) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.22m14767 · Cited by 3
Neuropeptidases, Stress, and Memory—A Promising Perspective
Prieto, I., Segarra, A. B., de Gasparo, M., & Ramírez‐Sánchez, M. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.4.487 · Cited by 3
Angiotensinergic neurotransmission in the bed nucleus of the stria terminalis is involved in cardiovascular responses to acute restraint stress in rats
Gomes‐de‐Souza, L., Santana, F. G., Duarte, J. O., Barretto‐de‐Souza, L., & Crestani, C. C. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02791-2 · Cited by 2
Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets
Song, J. (2026) · iScience · doi:10.1016/j.isci.2026.115447 · Cited by 3
The renin-angiotensin system, emotional stress and anxiety
Fontes, M. A. P., Kangussu, L. M., & Silva, A. C. S. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99618-1.00030-1 · Cited by 2
Sex-Dependent Effects of Angiotensin Type 2 Receptor–Expressing Medial Prefrontal Cortex Interneurons in Fear Extinction Learning
Smith, H. C., Yu, Z., Iyer, L., & Marvar, P. J. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100340 · Cited by 2
Self-citation
Preliminary study of ovariectomy and chronic losartan-induced alterations in brain AT1 receptors
Mehranfard, D., Linares, A., Chabbra, A., Campos, G. V., de Souza, A. M. A., Ji, H., West, C. A., Sandberg, K. L., & Speth, R. C. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147520 · Cited by 2
Sex-Dependent Effects of Angiotensin Type 2 Receptor Expressing Medial Prefrontal Cortex (mPFC) Interneurons in Fear Extinction Learning
Smith, H., Yu, Z., Iyer, L., & Marvar, P. J. (2024) · Physiology · doi:10.1152/physiol.2024.39.s1.1925 · Cited by 2
Self-citation

Authors: Marvar, P. J., Goodman, J., Fuchs, S., Choi, D. C., Banerjee, S., & Ressler, K. J.
Affiliations: Emory University (US)
ORCID: Marvar, Paul J.
Goodman, Jared
Ressler, Kerry J.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2014-06
Volume: 75
Issue: 11
Pages: 864-872
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.08.024
PMC: PMC3975818
OpenAlex: W2053674362
Cited by: 110
References: 82
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 4 · 2019: 19 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 11 · 2014: 7
FWCI: 4.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (P51OD011132)
National Heart, Lung, and Blood Institute (K99HL107675, R00HL107675)
National Institute of Mental Health (R01MH096764)
National Center for Research Resources (P51RR000165)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords: angiotensin II type 1 receptor, losartan, fear extinction, post-traumatic stress disorder, renin-angiotensin system, fear conditioning, amygdala, bed nucleus of the stria terminalis, c-fos, anxiety, stress response, cardiovascular response, neuroendocrine response
MeSH terms: Animals, Disease Models, Animal, Extinction, Psychological, Fear, Male, Memory, Mice, Inbred C57BL, Stress Disorders, Post-Traumatic, Losartan, Angiotensin II Type 1 Receptor Blockers, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Angiotensin Type 1 Receptor Inhibition Enhances the Extinction of Fear Memory

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks