Resting State Functional Connectivity and Depression: In Search of a Bottom Line
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Increased functional connectivity within the DMN and decreased functional connectivity between executive networks and the DMN are associated with the pathophysiology of MDD.
“Increased functional connectivity within the default mode network (DMN), a group of brain regions which show increased activity during rest and decreased activity during cognitively demanding tasks, as well as decreased functional connectivity between executive networks and the DMN, are associated with the pathophysiology of MDD [26, 27].”
From The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol (2022) · cites this paper as [27]
Cites
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
Sheline, Y. I., Price, J. L., Yan, Z., & Mintun, M. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000446107 · Cited by 1,196 · see citing works
Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder
Zhang, J., Wang, J., Wu, Q., Kuang, W., Huang, X., He, Y., & Gong, Q. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.018 · Cited by 951 · see citing works
Hamilton, J. P., Furman, D. J., Chang, C., Thomason, M. E., Dennis, E., & Gotlib, I. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.003 · Cited by 823 · see citing works
Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Unipolar and Bipolar Depression
Holtzheimer, P. E. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1456 · Cited by 608 · see citing works
Depression, rumination and the default network
Berman, M. G., Peltier, S., Nee, D. E., Kross, E., Deldin, P. J., & Jonides, J. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq080 · Cited by 568 · see citing works
Connolly, C. G., Wu, J., Ho, T. C., Hoeft, F., Wolkowitz, O., Eisendrath, S., Frank, G., Hendren, R., Max, J. E., Paulus, M. P., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.036 · Cited by 356 · see citing works
A systematic review of resting-state functional-MRI studies in major depression
Wang, L., Hermens, D. F., Hickie, I. B., & Lagopoulos, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.013 · Cited by 333 · see citing works
Making data sharing work: The FCP/INDI experience
Mennes, M., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.064 · Cited by 271 · see citing works
Davey, C. G., Harrison, B. J., Yücel, M., & Allen, N. B. (2012) · Psychological Medicine · doi:10.1017/s0033291712000323 · Cited by 176 · see citing works
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Johnson, M. W., Hendricks, P. S., Barrett, F. S., & Griffiths, R. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.010 · Cited by 506 · see citing works
Johansen, L., Liknaitzky, P., Nedeljkovic, M., Mastin-Purcell, L., & Murray, G. (2022) · Systematic Reviews · doi:10.1186/s13643-022-01930-7 · Cited by 11 · see citing works
“A recent randomised controlled trial found psilocybin-assisted psychotherapy and escitalopram to have similar anti-depressant effects for individuals with MDD [17].”
Background
- Authors
- Leibenluft, E., & Pine, D. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Leibenluft, Ellen
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 74
- Issue
- 12
- Pages
- 868-869
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2009957469
- Cited by
- 14
- References
- 10
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 3 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- resting-state functional connectivity, depression, neural circuits, brain network interactions, depression pathophysiology, functional MRI
- MeSH terms
- Major Depressive Disorder, Depressive Disorder, Major, Female, Gyrus Cinguli, Humans, Male, Rest
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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