Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder
Open accessAbstract
Background: Depression has been associated with functional alterations in several areas of the cingulate cortex. In this study we have taken a systematic approach to examining how alterations in functional connectivity vary across the functionally diverse subregions of the rostral cingulate cortex. Method: Eighteen patients with major depressive disorder, aged 15 to 24 years, were matched with 20 healthy control participants. Using resting-state functional connectivity magnetic resonance imaging (fcMRI), we systematically investigated the functional connectivity of four subregions of the rostral cingulate cortex. Voxelwise statistical maps of each subregion's connectivity with other brain areas were compared between the patient and control groups. Results: The depressed participants showed altered patterns of connectivity with ventral cingulate subregions. They showed increased connectivity between subgenual anterior cingulate cortex (ACC) and dorsomedial frontal cortex, with connectivity strength showing positive correlation with illness severity. Depressed participants also showed increased connectivity between pregenual ACC and left dorsolateral frontal cortex, and decreased connectivity between pregenual ACC and the caudate nucleus bilaterally. Conclusions: The results reinforce the importance of subgenual ACC for depression, and show a close link between brain regions that support self-related processes and affective visceromotor function. The pregenual ACC also has an important role, with its increased connectivity with dorsolateral frontal cortex suggesting heightened cognitive regulation of affect; and reduced connectivity with the caudate nucleus potentially underlying symptoms such as anhedonia, reduced motivation and psychomotor dysfunction.
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Connectivity between similar regions has been implicated with depressive symptomology.
“and connectivity between similar regions has been implicated both with depressive symptomology (Davey et al, 2012)”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Davey et al, 2012
Cortico-thalamic-striatal circuits have shown signs of abnormal function in depression in recent studies.
“Cortico-thalamic-striatal circuits have also shown signs of abnormal function in depression in recent studies.”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Davey et al, 2012
sgACC connectivity with limbic, thalamic, and striatal regions has been strongly implicated in the maladaptive emotion regulation underlying depression.
“For example, sgACC connectivity with limbic, thalamic, and striatal regions has been strongly implicated in the maladaptive emotion regulation underlying depression (Davey et al, 2012; Furman et al, 2011; Giacobbe et al, 2009; Lui et al, 2011)”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Davey et al, 2012
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- Davey, C. G., Harrison, B. J., Yuecel, M. & Allen, N. B. (2012). Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder. PSYCHOLOGICAL MEDICINE, 42 (10), pp.2071-2081. https://doi.org/10.1017/S0033291712000323. Publication Status: Accepted manuscript Persistent Link: http://hdl.handle.net/11343/44184
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- Authors
- Davey, C. G., Harrison, B. J., Yücel, M., & Allen, N. B.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Davey, C. G.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-03-09
- Volume
- 42
- Issue
- 10
- Pages
- 2071-2081
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2012623080
- Cited by
- 176
- References
- 57
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 5 · 2019: 13 · 2018: 16 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 19 · 2013: 14 · 2012: 1
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (628509, 628922)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, anterior cingulate cortex, functional connectivity, subgenual anterior cingulate cortex, pregenual anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, disease severity, anhedonia, adolescents
- MeSH terms
- Adolescent, Brain, Caudate Nucleus, Major Depressive Disorder, Female, Frontal Lobe, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Case-Control Studies, Young Adult, Functional Neuroimaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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