Cited by 176Functional Brain Connectivity StudiesTreatment of Major DepressionNeural and Behavioral Psychology Studies

Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder

Open access
Davey, C. G., Harrison, B. J., Yücel, M., Allen, N. B.·2012·Psychological Medicine

Abstract

Background: Depression has been associated with functional alterations in several areas of the cingulate cortex. In this study we have taken a systematic approach to examining how alterations in functional connectivity vary across the functionally diverse subregions of the rostral cingulate cortex. Method: Eighteen patients with major depressive disorder, aged 15 to 24 years, were matched with 20 healthy control participants. Using resting-state functional connectivity magnetic resonance imaging (fcMRI), we systematically investigated the functional connectivity of four subregions of the rostral cingulate cortex. Voxelwise statistical maps of each subregion's connectivity with other brain areas were compared between the patient and control groups. Results: The depressed participants showed altered patterns of connectivity with ventral cingulate subregions. They showed increased connectivity between subgenual anterior cingulate cortex (ACC) and dorsomedial frontal cortex, with connectivity strength showing positive correlation with illness severity. Depressed participants also showed increased connectivity between pregenual ACC and left dorsolateral frontal cortex, and decreased connectivity between pregenual ACC and the caudate nucleus bilaterally. Conclusions: The results reinforce the importance of subgenual ACC for depression, and show a close link between brain regions that support self-related processes and affective visceromotor function. The pregenual ACC also has an important role, with its increased connectivity with dorsolateral frontal cortex suggesting heightened cognitive regulation of affect; and reduced connectivity with the caudate nucleus potentially underlying symptoms such as anhedonia, reduced motivation and psychomotor dysfunction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1017/s0033291712000323

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Davey, C. G., Harrison, B. J., Yuecel, M. & Allen, N. B. (2012). Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder. PSYCHOLOGICAL MEDICINE, 42 (10), pp.2071-2081. https://doi.org/10.1017/S0033291712000323. Publication Status: Accepted manuscript Persistent Link: http://hdl.handle.net/11343/44184

Cited by

Sorted by citations

Authors
Davey, C. G., Harrison, B. J., Yücel, M., & Allen, N. B.
Affiliations
The University of Melbourne (AU)
Corresponding author
Davey, C. G.
Venue
Psychological Medicine
Published
2012-03-09
Volume
42
Issue
10
Pages
2071-2081
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
OpenAlex
W2012623080
Cited by
176
References
57
Citations by year
2026: 7 · 2025: 17 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 5 · 2019: 13 · 2018: 16 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 19 · 2013: 14 · 2012: 1
FWCI
8.18
Type
journal article
Language
en
Open access
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council (628509, 628922)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
major depressive disorder, anterior cingulate cortex, functional connectivity, subgenual anterior cingulate cortex, pregenual anterior cingulate cortex, dorsolateral prefrontal cortex, caudate nucleus, disease severity, anhedonia, adolescents
MeSH terms
Adolescent, Brain, Caudate Nucleus, Major Depressive Disorder, Female, Frontal Lobe, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Case-Control Studies, Young Adult, Functional Neuroimaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review