Cited by 227Functional Brain Connectivity StudiesTreatment of Major DepressionNeural and Behavioral Psychology Studies

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Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression

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Ho, Tiffany C., Connolly, Colm G., Henje Blom, Eva, LeWinn, Kaja Z., Strigo, Irina A., Paulus, Martin P., Frank, Guido, Max, Jeffrey E., Wu, Jing, Chan, Melanie, Tapert, Susan F., Simmons, Alan N., Yang, Tony T.·2015·Biological Psychiatry

DOI 10.1016/j.biopsych.2014.09.002PMC PMC4362932

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Abstract

Background Functional magnetic resonance imaging research suggests that major depressive disorder (MDD) in both adults and adolescents is marked by aberrant connectivity of the default mode network (DMN) during resting state. However, emotional dysregulation is also a key feature of MDD. No studies to date have examined emotion-related DMN pathology in adolescent depression. Comprehensively understanding the dynamics of DMN connectivity across brain states in individuals with depression with short disease histories could provide insight into the etiology of MDD.Methods We collected functional magnetic resonance imaging data during an emotion identification task and during resting state from 26 medication-free adolescents (13-17 years old) with MDD and 37 well-matched healthy control subjects. We examined between-group differences in blood oxygenation level-dependent task responses and emotion-dependent and resting-state functional connectivity of the two primary nodes of the DMN: medial prefrontal cortex and posterior cingulate cortex (PCC). Additionally, we examined between-group differences in DMN functional connectivity and its relationship to depression severity and onset.Results Relative to healthy control subjects, unmedicated adolescents with MDD demonstrated reduced medial prefrontal cortex and PCC emotion-related deactivation and greater medial prefrontal cortex and PCC emotion-dependent functional connectivity with precuneus, cingulate gyrus, and striatum/subcallosal cingulate gyrus. The PCC-subcallosal cingulate connectivity remained inflexibly elevated in the subjects with MDD versus healthy control subjects during resting state. Stronger PCC emotion-dependent functional connectivity was associated with greater depression severity and an earlier age of depression onset.Conclusions Adolescent depression is associated with inflexibly elevated DMN connections. Given more recent evidence of DMN maturation throughout adolescence, our findings suggest that early-onset depression adversely affects normal development of functional brain networks.

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Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358

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Myslowski, J., McClure, S. M., Lisinski, J. M., Tomlinson, D. C., Kablinger, A. S., MacKillop, J. M., Koffarnus, M. N., Fontes, R. M., Bickel, W. K., & LaConte, S. M. (2024) · Brain Connectivity · doi:10.1089/brain.2024.0025 · Cited by 4
Age-related changes in depression symptom networks in children in China with parental absence: A comparative analysis of youth aged nine to 18
Ruan, Q.-N., Li, C., Su, X., & Yan, W. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.082 · Cited by 4
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Caceres, G. A., Scambray, K. A., Malee, K., Smith, R. A., Williams, P. L., Wang, L., & Jenkins, L. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.026 · Cited by 4
Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions
Nie, H., Yu, T., Zou, Y., Li, Y., Chen, J., Xia, J., Luo, Q., & Peng, H. (2024) · Brain Imaging and Behavior · doi:10.1007/s11682-024-00859-w · Cited by 5
Effects of sMRI-guided rTMS on brain function and structure in major depressive disorder
Guo, P., Liu, X., Sun, Y., Zhi, Q., & Xia, Y. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119772 · Cited by 4
Machine learning of whole-brain resting-state fMRI signatures for individualized grading of frontal gliomas
Hu, Y., Cao, X., Chen, H., Geng, D., & Lv, K. (2025) · Cancer Imaging · doi:10.1186/s40644-025-00920-x · Cited by 3
Identifying diagnostic neuroimaging biomarkers for adolescent major depressive disorder
Dai, T., Cerins, A., Zalesky, A., & Rodger, J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120969 · Cited by 3
A systematic review on mindfulness-based immersive interventions in depressive disorders
Tan, P., Wu, Y., Chen, X., Chen, J., Guo, Z., Lu, X., Chen, J., & Zhang, H. (2026) · npj Mental Health Research · doi:10.1038/s44184-026-00205-6 · Cited by 3
Causal structural covariance network identifies progressive gray matter atrophy in adolescents with major depressive disorder
Chen, J., Jin, X., Gao, J., Zhang, Y., Zhang, Y., Bai, C., Xu, F., Yao, Y., ZHANG, W., Yang, Y., et al. (2025) · Psychological Medicine · doi:10.1017/s0033291725101542 · Cited by 3
Imagerie cérébrale et déconstruction de l’esprit
de Beaurepaire, R. (2016) · L Évolution Psychiatrique · doi:10.1016/j.evopsy.2016.01.007 · Cited by 3
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McVoy, M. K., Chumachenko, S. Y., Gersten, M. B., Wade, B., Corcelles, O., Yala, J. A., Gray, M., Morris, A., Jamil, A., Cassono, P., et al. (2025) · Journal of Child and Adolescent Psychopharmacology · doi:10.1177/10445463251358742 · Cited by 3
Rationale and design of a double-blinded, randomized placebo-controlled trial of 40 Hz light neurostimulation therapy for depression (FELIX)
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Li, W., Yin, Y., You, Z., Zhang, M., Wang, C., Lan, X., Mai, S., Zhang, F., Hu, Z., Liu, G., et al. (2025) · General Psychiatry · doi:10.1136/gpsych-2024-101749 · Cited by 2
Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression
Xu, M., Li, N., Lv, Y., Yang, W., Yu, Z., Zhang, Y., Guo, Y., & Chen, X. (2025) · Advanced Science · doi:10.1002/advs.202506032 · Cited by 3
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Karl, V., Bjørndal, L. D., Aksnes, E. R., Teulings, I. J. E., MacSweeney, N., Beck, D., Westlye, L. T., Ebrahimi, O. V., & Tamnes, C. K. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-02989-6 · Cited by 2
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Zhong, S.-M., Chen, C., Chen, P., Tang, X.-Y., Chen, G.-M., Lai, S.-K., Zhang, Y.-L., Ma, W.-H., Zhang, Y., Zhang, S., et al. (2026) · Psychological Medicine · doi:10.1017/s0033291725102687 · Cited by 1
Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents
Coury, S. M., López, V., Bajwa, Z., Garcia, J. M., Teresi, G. I., Kuhlman, K. R., Li, Y., Cole, S. W., Miklowitz, D. J., Pappas, I., et al. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100718 · Cited by 2
Systematic review of affective functional magnetic resonance imaging in pediatric major depressive disorder.
Turpyn, C. C., Niehaus, C. E., Gonçalves, S. F., & Jenness, J. L. (2020) · Journal of Pediatric Neuropsychology · doi:10.1007/s40817-020-00080-9 · Cited by 2
Dynamic functional brain networks underlying the temporal inertia of negative emotionsPreprint
Gaviria, J., Rey, G., Bolton, T. A. W., Ville, D. V. D., & Vuilleumier, P. O. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.26.437275 · Cited by 2
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Gaviria, J., Celen, Z., Smith, M. M., Peek, L., Brosset, S., Vuilleumier, P., Van De Ville, D., Merglen, A., Klauser, P., & Piguet, C. (2024) · doi:10.1101/2024.10.16.616959 · Cited by 1
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Kirsch, D. E., Ho, T. C., Wassum, K. M., Ray, L. A., & Grodin, E. N. (2025) · Addiction Biology · doi:10.1111/adb.70083 · Cited by 1
Association between anhedonia and ventral striatum-MPFC connectivity in first-episode, treatment-naïve major depressive disorder
Cao, Y., Ban, M., Wang, D., Kong, L., He, J., Chen, S., Zhu, X., & Yuan, F. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120214 · Cited by 1
Default mode network and reward network dysconnectivity among young individuals with major depressive disorder with and without systemic low-grade inflammation
Bai, Y., Cheng, L., Lin, W.-C., Hsu, J.-W., Chen, L., Tu, P., Li, C., Tsai, S., Chen, L.-C., Su, T., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120491 · Cited by 1
Alterations in resting-state brain activity patterns following antidepressant treatment: insights from a coordinate-based meta-analysis
Shi, R., Dou, Y., He, Y., Luo, M., Yuan, C., Wang, Y., Lan, D., Yang, D., Shen, Y., Su, Y., et al. (2025) · Psychological Medicine · doi:10.1017/s0033291725102699 · Cited by 1
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Huang, X., Gao, J., Tang, X., Wang, Y., Gao, F., Tian, J., Cheng, S., Li, Y., Zhang, X., & Sun, H. (2026) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-026-01078-5 · Cited by 1
Alpha-band fronto-limbic hyperconnectivity in adolescents with major depression and suicidal ideation
Zhang, M., Lan, X., Li, W., Luo, Z., Liu, G., Wu, Z., Yao, Y., Wu, A., & Zhou, Y. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08096-9 · Cited by 1
Functional Connectivity Alterations in Major Depressive Disorder
Sridhar, M., Wiafe, S.-L., Baker, B., & Calhoun, V. D. (2026) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi61048.2026.11515707 · Cited by 1
Brain development mediates the relationship between self-reported poor parental monitoring and adolescent anxiety
Li, Y., Zhou, Z., Zhang, Y., Ai, H., Liu, M., Liu, J., Wang, L., Qiu, J., Han, Z. R., Zhang, Z., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103514 · Cited by 1
Reverse phase protein array-based investigation of mitochondrial genes reveals alteration of glutaminolysis in the parahippocampal cortex of people who died by suicide
Dóra, F., Hajdu, T., Renner, É., Paál, K., Alpár, A., Palkovits, M., Chinopoulos, C., & Dobolyi, Á. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03137-x · Cited by 1
The impact of primary mental healthcare on core symptoms of depression among underrepresented adolescents: a network analysis perspective
Zhang, Q., Li, R., Li, W., Liu, X., Gong, J., An, X., Feng, Z., Chen, Z., & Zhang, J. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06992-0 · Cited by 1
Altered intrinsic functional brain architecture in children at familial risk of major depression
Biederman, J., Uchida, M., Chai, X. J., Hirshfeld‐Becker, D. R., Whitfield, S., & Gabrieli, J. D. E. (2016) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(16)31857-0 · Cited by 1
Altered functional connectivity relates to motor performance deficits in bipolar but not unipolar depressionPreprint
Marten, L. E., Singh, A., Muellen, A. M., Noack, S. M., Kozyrev, V., Schweizer, R., & Goya‐Maldonado, R. (2021) · medRxiv · doi:10.1101/2021.11.26.21266905 · Cited by 1
Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depressionPreprint
Qu, Y. L., Chopra, S., Qu, S., Cocuzza, C. V., Labache, L., Bauer, C. C. C., Morfini, F., Whitfield, S., Slavich, G. M., Joormann, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.25.620373 · Cited by 1
Brain imaging and the deconstruction of mind
de Beaurepaire, R. (2016) · L Évolution Psychiatrique · doi:10.1016/j.evopsy.2016.02.001

Authors: Ho, T. C., Connolly, C. G., Henje Blom, E., LeWinn, K. Z., Strigo, I. A., Paulus, M. P., Frank, G., Max, J. E., Wu, J., Chan, M., Tapert, S. F., Simmons, A. N., & Yang, T. T.
Affiliations: University of California, San Francisco (US)
University of California San Diego (US)
VA San Diego Healthcare System (US)
University of Colorado Denver (US)
University of Washington (US)
Corresponding author: Ho, Tiffany C.
ORCID: Ho, Tiffany C.
Connolly, Colm G.
LeWinn, Kaja Z.
Strigo, Irina A.
Paulus, Martin P.
Frank, Guido
Max, Jeffrey E.
Wu, Jing
Tapert, Susan F.
Simmons, Alan N.
Yang, Tony T.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2015-11
Volume: 78
Issue: 9
Pages: 635-646
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2014.09.002
PMC: PMC4362932
OpenAlex: W1970348155
Cited by: 227
References: 128
Citations by year: 2026: 20 · 2025: 28 · 2024: 30 · 2023: 17 · 2022: 18 · 2021: 29 · 2020: 12 · 2019: 22 · 2018: 15 · 2017: 13 · 2016: 13 · 2015: 9
FWCI: 6.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Mental Health (R01MH085734, R01MH085734-02S1, R01MH085734-05S1, K01MH097978)
Swedish Research Council (350-2012-303 to EHB)
Swedish Society of Medicine (SLS-244671 to EHB)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: adolescent depression, major depressive disorder, default mode network, functional connectivity, resting-state functional connectivity, medial prefrontal cortex, posterior cingulate cortex, subcallosal cingulate, precuneus, emotional dysregulation, depression severity
MeSH terms: Facial Recognition, Adolescent, Psychology, Adolescent, Brain, Brain Mapping, Major Depressive Disorder, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Oxygen, Photic Stimulation, Psychoacoustics, Rest, Severity of Illness Index

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Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression

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