Cited by 227Functional Brain Connectivity StudiesTreatment of Major DepressionNeural and Behavioral Psychology Studies

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Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression

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Ho, Tiffany C., Connolly, Colm G., Henje Blom, Eva, LeWinn, Kaja Z., Strigo, Irina A., Paulus, Martin P., Frank, Guido, Max, Jeffrey E., Wu, Jing, Chan, Melanie, Tapert, Susan F., Simmons, Alan N., Yang, Tony T.·2015·Biological Psychiatry

DOI 10.1016/j.biopsych.2014.09.002PMC PMC4362932

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Abstract

Background Functional magnetic resonance imaging research suggests that major depressive disorder (MDD) in both adults and adolescents is marked by aberrant connectivity of the default mode network (DMN) during resting state. However, emotional dysregulation is also a key feature of MDD. No studies to date have examined emotion-related DMN pathology in adolescent depression. Comprehensively understanding the dynamics of DMN connectivity across brain states in individuals with depression with short disease histories could provide insight into the etiology of MDD.Methods We collected functional magnetic resonance imaging data during an emotion identification task and during resting state from 26 medication-free adolescents (13-17 years old) with MDD and 37 well-matched healthy control subjects. We examined between-group differences in blood oxygenation level-dependent task responses and emotion-dependent and resting-state functional connectivity of the two primary nodes of the DMN: medial prefrontal cortex and posterior cingulate cortex (PCC). Additionally, we examined between-group differences in DMN functional connectivity and its relationship to depression severity and onset.Results Relative to healthy control subjects, unmedicated adolescents with MDD demonstrated reduced medial prefrontal cortex and PCC emotion-related deactivation and greater medial prefrontal cortex and PCC emotion-dependent functional connectivity with precuneus, cingulate gyrus, and striatum/subcallosal cingulate gyrus. The PCC-subcallosal cingulate connectivity remained inflexibly elevated in the subjects with MDD versus healthy control subjects during resting state. Stronger PCC emotion-dependent functional connectivity was associated with greater depression severity and an earlier age of depression onset.Conclusions Adolescent depression is associated with inflexibly elevated DMN connections. Given more recent evidence of DMN maturation throughout adolescence, our findings suggest that early-onset depression adversely affects normal development of functional brain networks.

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Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
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Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358

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Mao, Z., Wang, X., Xu, X., Cui, Z.-Q., Pan, L., Ning, X.-J., Xu, B.-X., Ma, L., Ling, Z., Jia, J., et al. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.241468 · Cited by 36
Feasibility and preliminary efficacy of a novel RDoC-based treatment program for adolescent depression: "Training for Awareness Resilience and Action" (TARA)-A pilot study
Henje Blom, E., Tymofiyeva, O., Chesney, M. A., Ho, T. C., Moran, P., Connolly, C. G., Duncan, L. G., Baldini, L., Weng, H. Y., Acree, M., et al. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00208 · Cited by 33
“The second target in TARA is practicing the ability to shift neural activation away from the DMN, which has been found to be significantly altered in fMRI studies of depressed adolescents (34).”
Background
Hyperactivation in Cognitive Control and Visual Attention Brain Regions During Emotional Interference in Adolescent Depression
Colich, N. L., Ho, T. C., Foland‐Ross, L. C., Eggleston, C., Ordaz, S. J., Singh, M. K., & Gotlib, I. H. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.09.001 · Cited by 32
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Xiang, Q., Chen, K., Peng, L., Luo, J., Jiang, J., Chen, Y., Lan, L., Song, H., & Zhou, X. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.020 · Cited by 33
Repetitive Transcranial Magnetic Stimulation for Adolescent Major Depressive Disorder: A Focus on Neurodevelopment
Oberman, L. M., Hynd, M., Nielson, D. M., Towbin, K. E., Lisanby, S. H., & Stringaris, A. K. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.642847 · Cited by 30
Disentangling the Neural Basis of Cognitive Behavioral Therapy in Psychiatric Disorders: A Focus on Depression
Chalah, M. A., & Ayache, S. S. (2018) · Brain Sciences · doi:10.3390/brainsci8080150 · Cited by 29
Dynamic functional brain networks underlying the temporal inertia of negative emotions
Gaviria, J., Rey, G., Bolton, T. A. W., Ville, D. V. D., & Vuilleumier, P. O. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118377 · Cited by 28
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Jin, J., Narayanan, A., Perlman, G., Luking, K. R., DeLorenzo, C., Hajcak, G., Klein, D. N., Kotov, R., & Mohanty, A. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.02.002 · Cited by 31
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Luan, Y., Wang, C., Jiao, Y., Tang, T., Zhang, J., & Teng, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00055 · Cited by 31
Effects of low- and high-intensity exercise on emotional face processing: an fMRI face-matching study
Schmitt, A., Martin, J. A., Rojas, S., Vafa, R., Scheef, L., Strüder, H. K., & Boecker, H. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz042 · Cited by 28
Diverse adolescents’ transcendent thinking predicts young adult psychosocial outcomes via brain network development
Gotlieb, R. J. M., Yang, X., & Immordino‐Yang, M. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-56800-0 · Cited by 29
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Lee, J., Pavuluri, M. N., Kim, J. H., Suh, S., Kim, I. S., & Lee, M. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.04.008 · Cited by 27
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Kerestes, R., Segreti, A. M., Pan, L. A., Phillips, M. L., Birmaher, B. B., Brent, D. A., & Ladouceur, C. D. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.013 · Cited by 25
Contributions of default mode network stability and deactivation to adolescent task engagement
McCormick, E. M., & Telzer, E. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-36269-4 · Cited by 30
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Cui, H., Ding, H., Hu, L., Zhao, Y., Shu, Y., & Voon, V. (2024) · Psychological Medicine · doi:10.1017/s0033291724002289 · Cited by 25
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Shao, R., Liu, H., Huang, C., Chen, Y.-L., Gao, M., Lee, S., Lin, C., & Lee, T. M. C. (2019) · Psychological Medicine · doi:10.1017/s0033291719002782 · Cited by 25
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Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents
Teng, T., Huang, F., Xu, M. G., Li, X., Zhang, L., Yin, B., Cai, Y. A., Chen, F., Zhang, L., Zhang, J., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02122-w · Cited by 26
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Altered brain regional homogeneity is associated with cognitive dysfunction in first-episode drug-naive major depressive disorder: A resting-state fMRI study
Ni, S., Gao, S., Ling, C., Jiang, J., Wu, F., Peng, T., Sun, J., Zhang, N., & Xu, X. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.003 · Cited by 22
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Ho, T. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.012 · Cited by 22
Dynamic network characteristics of adolescents with major depressive disorder: Attention network mediates the association between anhedonia and attentional deficit
Wen, Y., Li, H., Huang, Y., Qiao, D., Ren, T., Lei, L., Li, G., Yang, C., Xu, Y., Han, M., et al. (2023) · Human Brain Mapping · doi:10.1002/hbm.26474 · Cited by 21
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Chao, Z. C., Dillon, D. G., Liu, Y.-H., Barrick, E. M., & Wu, C. (2022) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220046 · Cited by 20
Emotion dysregulation and functional connectivity in children with and without a history of major depressive disorder
Lopez, K. C., Luby, J. L., Belden, A. C., & Barch, D. M. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-018-0564-x · Cited by 24
Neural connectivity biotypes: associations with internalizing problems throughout adolescence
Chahal, R., Weissman, D. G., Hallquist, M. N., Robins, R. W., Hastings, P. D., & Guyer, A. E. (2020) · Psychological Medicine · doi:10.1017/s003329172000149x · Cited by 20
Trait self-control mediates the association between resting-state neural correlates and emotional well-being in late adolescence
Li, Q., Xiang, G., Song, S., Xiao, M., & Chen, H. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab046 · Cited by 21
Migraine in the Young Brain: Adolescents vs. Young Adults
Colon, É., Ludwick, A., Wilcox, S. L., Youssef, A. M., Danehy, A. R., Fair, D. A., Lebel, A., Burstein, R., Becerra, L. R., & Borsook, D. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00087 · Cited by 22
The Cognitive Neuropsychology of Depression in Adolescents
Oliver, A., Pile, V., Elm, D., & Lau, J. Y. F. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00187-0 · Cited by 19
The characteristics of brain network in patient with post-stroke depression under cognitive task condition
Peng, Y., Zheng, Y., Ziwen, Y., Guo, J., Fan, C., Li, C., Deng, J., Song, S., Qiao, J., & Wang, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1242543 · Cited by 20

Authors: Ho, T. C., Connolly, C. G., Henje Blom, E., LeWinn, K. Z., Strigo, I. A., Paulus, M. P., Frank, G., Max, J. E., Wu, J., Chan, M., Tapert, S. F., Simmons, A. N., & Yang, T. T.
Affiliations: University of California, San Francisco (US)
University of California San Diego (US)
VA San Diego Healthcare System (US)
University of Colorado Denver (US)
University of Washington (US)
Corresponding author: Ho, Tiffany C.
ORCID: Ho, Tiffany C.
Connolly, Colm G.
LeWinn, Kaja Z.
Strigo, Irina A.
Paulus, Martin P.
Frank, Guido
Max, Jeffrey E.
Wu, Jing
Tapert, Susan F.
Simmons, Alan N.
Yang, Tony T.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2015-11
Volume: 78
Issue: 9
Pages: 635-646
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2014.09.002
PMC: PMC4362932
OpenAlex: W1970348155
Cited by: 227
References: 128
Citations by year: 2026: 20 · 2025: 28 · 2024: 30 · 2023: 17 · 2022: 18 · 2021: 29 · 2020: 12 · 2019: 22 · 2018: 15 · 2017: 13 · 2016: 13 · 2015: 9
FWCI: 6.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Mental Health (R01MH085734, R01MH085734-02S1, R01MH085734-05S1, K01MH097978)
Swedish Research Council (350-2012-303 to EHB)
Swedish Society of Medicine (SLS-244671 to EHB)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: adolescent depression, major depressive disorder, default mode network, functional connectivity, resting-state functional connectivity, medial prefrontal cortex, posterior cingulate cortex, subcallosal cingulate, precuneus, emotional dysregulation, depression severity
MeSH terms: Facial Recognition, Adolescent, Psychology, Adolescent, Brain, Brain Mapping, Major Depressive Disorder, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Oxygen, Photic Stimulation, Psychoacoustics, Rest, Severity of Illness Index

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Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression

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