The DOI matches its Crossref record; 74 of the 76 references it cites were found in a registry or an index.
Oxytocin Facilitates the Extinction of Conditioned Fear in Humans
Abstract
Background Current neurocircuitry models of anxiety disorders posit a lack of inhibitory tone in the amygdala during acquisition of Pavlovian fear responses and deficient encoding of extinction responses in amygdala-medial prefrontal cortex circuits. Competition between these two responses often results in a return of fear, limiting control over anxiety. However, one hypothesis holds that a pharmacologic strategy aimed at reducing amygdala activity while simultaneously augmenting medial prefrontal cortex function could facilitate the extinction of conditioned fear.Methods Key among the endogenous inhibitors of amygdala activity in response to social fear signals is the hypothalamic peptide oxytocin. To address the question whether oxytocin can strengthen Pavlovian extinction beyond its role in controlling social fear, we conducted a functional magnetic resonance imaging experiment with 62 healthy male participants in a randomized, double-blind, parallel-group, placebo-controlled design. Specifically, subjects were exposed to a Pavlovian fear conditioning paradigm before receiving an intranasal dose (24 IU) of synthetic oxytocin or placebo.Results Oxytocin, when administered intranasally after Pavlovian fear conditioning, was found to increase electrodermal responses and prefrontal cortex signals to conditioned fear in the early phase of extinction and to enhance the decline of skin conductance responses in the late phase of extinction. Oxytocin also evoked an unspecific inhibition of amygdalar responses in both phases.Conclusions Collectively, our findings identify oxytocin as a differentially acting modulator of neural hubs involved in Pavlovian extinction. This specific profile of oxytocin action may open up new avenues for enhancing extinction-based therapies for anxiety disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additionally, OXT strengthens top-down cognitive control strengthens top-down cognitive control by enhancing activity in the middle frontal gyrus (MFG) (Eckstein et al., 2015;Striepens et al., 2016).”
From Oxytocin enhances the pain‐relieving effects of social support in romantic couples (2019) · cites this paper as Eckstein et al., 2015
In the citing paper
“Additionally, an OXT-induced increase in activity in the PFC, where OXT receptors are highly expressed (Boccia, Petrusz, Suzuki, Marson, & Pedersen, 2013), may reflect enhanced top-down cognitive control that has been previously observed in the context of food craving behavior (Striepens et al., 2016) and fear extinction (Eckstein et al., 2015).”
From Oxytocin enhances the pain‐relieving effects of social support in romantic couples (2019) · cites this paper as Eckstein et al., 2015
In the citing paper
“An important consequence of oxytocin-induced inhibition of fear is the ability to reorganize experiences and memories.”
From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Eckstein et al., 2015
In the citing paper
“When fear is absent, it is possible to introduce new ways of thinking and even exchange emotional links to memories (Eckstein et al., 2015; Engert et al., 2016).”
From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Eckstein et al., 2015
In the citing paper
“and mPFC/aMCC activities are modulated by administered OT (Sabihi et al., 2014; Eckstein et al., 2015; Liu et al., 2017; Wang et al., 2017).”
From A neurobiological association of revenge propensity during intergroup conflict (2020) · cites this paper as Eckstein et al., 2015
In the citing paper
“Oxytocin has demonstrated the ability to enhance fear extinction in preclinical models (Eskandarian et al., 2013) and among healthy individuals (Acheson et al., 2013; Eckstein et al., 2014).”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Eckstein et al., 2014
In the citing paper
“A similar pattern was shown in healthy individuals administered oxytocin after fear conditioning: participants showed increased fear expression during early-stage extinction and then facilitated decline of physiological distress at the late stage of extinction (Eckstein et al., 2014).”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Eckstein et al., 2014
In the citing paper
“In healthy participants, intranasal OXT has been shown to facilitate the extinction of conditioned fear (Acheson et al., 2013;Eckstein et al., 2015).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Eckstein et al., 2015
In the citing paper
“Three studies investigated the effects of oxytocin on startle response to learned threat cues after conditioning and on learned threat following extinction (Acheson et al., 2013;Eckstein et al., 2015;Eckstein et al., 2016).”
From Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans (2018) · cites this paper as Eckstein et al., 2015
Citations
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
(1970) · Cited by 24,983
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · cited 1×
“Given the complementary effect profile of OXT compared with the medial PFC hypoactivation and amygdala hyperactivation typically observed in anxiety disorders (69,12), the neuropeptide may qualify as a treatment option for the pharmacologic augmentation of exposure therapies in clinical trials.”
Region of interest analysis using an SPM toolbox
Brett, M. (2002) · NeuroImage · Cited by 2,273
A Multidimensional Meta-Analysis of Psychotherapy for PTSD
Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.214 · Cited by 1,938
Pain and emotion interactions in subregions of the cingulate gyrus
Vogt, B. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1704 · Cited by 1,810
Research works printed but not linked: 1
- Etkin, 2007, Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia, Am J Psychiatry, 164, 1476, 10.1176/appi.ajp.2007.07030504 · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 210
de Sá, D. S. F., Römer, S., Brueckner, A. H., Issler, T. C., Hauck, A., & Michael, T. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0593-3 · Cited by 24
Pawłowska, A., Borg, C., de Jong, P. J., & Both, S. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103714 · Cited by 24
Dyadic Coping and Its Underlying Neuroendocrine Mechanisms – Implications for Stress Regulation
Zietlow, A., Eckstein, M., Hernández, C., Nonnenmacher, N., Reck, C., Schaer, M., Bodenmann, G., Heinrichs, M., & Ditzen, B. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02600 · Cited by 22
Self-citationOxytocin-Augmented Psychotherapy: Beware of Context
Hurlemann, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.188 · Cited by 22
Self-citationJanezic, E. M., Uppalapati, S., Nagl, S., Contreras, M., French, E. D., & Fellous, J. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000270 · Cited by 23
Schultebraucks, K., Maslahati, T., Wingenfeld, K., Hellmann‐Regen, J., Kraft, J., Kownatzki, M., Behnia, B., Ripke, S., Otte, C., & Roepke, S. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01247-4 · Cited by 23
Trauma Disclosure Moderates the Effects of Oxytocin on Intrusions and Neural Responses to Fear
Scheele, D., Lieberz, J., Patin, A., Engels, C., Schneider, L., Stoffel‐Wagner, B., Becker, B., & Hurlemann, R. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000496056 · Cited by 20
Self-citationSarmanlu, M., Kuypers, K. P. C., Vizeli, P., & Kvamme, T. L. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110843 · Cited by 21
Effects of oxytocin on background anxiety in rats with high or low baseline startle
Ayers, L. W., Agostini, A., Schulkin, J. A., & Rosen, J. B. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4267-0 · Cited by 20
New dimensions in the use of rodent behavioral tests for novel drug discovery and development
Hoffman, K. L. (2016) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2016.1153624 · Cited by 19
Oxytocin in dorsal hippocampus facilitates auditory fear memory extinction in rats
Bazaz, A., Ghanbari, A., Vafaei, A. A., Khaleghian, A., & Rashidy‐Pour, A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108844 · Cited by 19
The neurobiology of Pavlovian safety learning: Towards an acquisition-expression framework
Laing, P. A. F., Felmingham, K. L., Davey, C. G., & Harrison, B. J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104882 · Cited by 20
Coenjaerts, M., Adrovic, B., Trimborn, I., Philipsen, A., Hurlemann, R., & Scheele, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-29754-y · Cited by 17
Self-citationPost-retrieval oxytocin facilitates next day extinction of threat memory in humans
Hu, J., Wang, Z., Feng, X., Long, C., & Schiller, D. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5074-6 · Cited by 18
Morr, M., Noell, J., Sassin, D., Daniels, J., Philipsen, A., Becker, B., Stoffel‐Wagner, B., Hurlemann, R., & Scheele, D. (2022) · Advanced Science · doi:10.1002/advs.202105336 · Cited by 16
Self-citationOxytocin in neurodevelopmental disorders: Autism spectrum disorder and Prader-Willi syndrome
Josselsohn, A., Zhao, Y., Espinoza, D., & Hollander, E. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108734 · Cited by 16
Peripartum effects of synthetic oxytocin: The good, the bad, and the unknown
Rashidi, M., Maier, E., Dekel, S., Sütterlin, M., Wolf, R. C., Ditzen, B., Grinevich, V., & Herpertz, S. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104859 · Cited by 18
Self-citationSchuh‐Hofer, S., Eichhorn, N., Grinevich, V., & Treede, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00161 · Cited by 16
Self-citationIncreased Temporal Discounting in Social Anxiety Disorder Normalizes after Oxytocin Treatment
Hurlemann, R., Scheele, D., Kinfe, T. M., Berger, R., Philipsen, A., Voncken, M. J., Kuypers, K. P. C., & Schruers, K. R. J. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000495259 · Cited by 16
Self-citationFarley, D., Piszczek, Ł., & Bąbel, P. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.05.003 · Cited by 15
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16
Zarei, S. A., Sheibani, V., Tomaz, C. A. B., & Mansouri, F. A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.050 · Cited by 17
Coenjaerts, M., Trimborn, I., Adrovic, B., Stoffel‐Wagner, B., Cahill, L. F., Philipsen, A., Hurlemann, R., & Scheele, D. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119689 · Cited by 17
Self-citationMicrobes, oxytocin and stress: Converging players regulating eating behavior
Cuesta‐Marti, C., Uhlig, F., Muguerza, B., Hyland, N. P., Clarke, G. A., & Schellekens, H. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13243 · Cited by 17
Engel, S., Schumacher, S., Niemeyer, H., Kuester, A., Burchert, S., Klusmann, H., Rau, H., Willmund, G., & Knaevelsrud, C. (2021) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.1886499 · Cited by 14
Oxytocin/vasopressin-like neuropeptide signaling in insects
Muratspahić, E., Monjon, E., Duerrauer, L., Rogers, S. M., Cullen, D. A., Broeck, J. V., & Gruber, C. W. (2020) · Vitamins and hormones · doi:10.1016/bs.vh.2019.08.011 · Cited by 15
Selective sub-nucleus effects of intra-amygdala oxytocin on fear extinction
Gunduz‐Cinar, O., Brockway, E. T., Castillo, L. I., Pollack, G. A., Erguven, T., & Holmes, A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112798 · Cited by 14
Beyond tingles: An exploratory qualitative study of the Autonomous Sensory Meridian Response (ASMR)
Trenholm-Jensen, E. A., Burns, L., Trenholm, J., & Hand, C. J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277962 · Cited by 21
Ditzen, B., Eckstein, M., Fischer, M. S., & Aguilar‐Raab, C. (2019) · Psychotherapeut · doi:10.1007/s00278-019-00379-9 · Cited by 14
Self-citationEye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces
Marsh, N., Scheele, D., Postin, D., Onken, M., & Hurlemann, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.629760 · Cited by 12
Self-citationThe neuropeptide oxytocin modulates consumer brand relationships
Fürst, A., Thron, J., Scheele, D., Marsh, N., & Hurlemann, R. (2015) · Scientific Reports · doi:10.1038/srep14960 · Cited by 14
Self-citationCan oxytocin inhibit stress-induced hyperalgesia?
Li, Y.-X., An, H. Y., Wen, Z., Tao, Z.-Y., & Cao, D. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101996 · Cited by 13
Latifi, A., & Jaroslav Flegr, A. (2025) · Biomedicines · doi:10.3390/biomedicines13071731 · Cited by 15
Intranasal oxytocin decreases cross-frequency coupling of neural oscillations at rest
Rutherford, H. J. V., Guo, X. M., Wu, J., Graber, K. M., Hayes, N. J., Pelphrey, K. A., & Mayes, L. C. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.09.017 · Cited by 13
Daniëls, N., Prinsen, J., Soriano, J. R., & Alaerts, K. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.08.004 · Cited by 11
Serotonin mediates the panicolytic-like effect of oxytocin in the dorsal periaqueductal gray
Sergio, T. D. O., Frias, A. T., Vilela‐Costa, H. H., de Oliveira, D. C., Zuardi, A. W., & Zangrossi, H. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120907960 · Cited by 11
Salivary oxytocin and amygdalar alterations in functional neurological disorders
Weber, S., Stoffel, N., Ansede‐Bermejo, J. J., Cruz, R., Bolt, Á. D. R., Bruckmaier, R. M., Carracedo, Á., & Aybek, S. (2024) · Brain Communications · doi:10.1093/braincomms/fcae455 · Cited by 10
Fu, K., Xu, S., Zhang, Z., Liu, D. C., Xu, T., Zhang, Y., Zhou, F., Zhang, X., Lan, C., Wang, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202503251 · Cited by 13
Self-citationDou, H., Zou, L., Becker, B., & Lei, Y. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05720-8 · Cited by 10
Self-citationAugmenting Treatment for Posttraumatic Stress Disorder and Co-Occurring Conditions with Oxytocin
Flanagan, J. C., & Mitchell, J. (2019) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-019-00171-1 · Cited by 12
Takiguchi, S., Makita, K., Fujisawa, T. X., Nishitani, S., & Tomoda, A. (2023) · Frontiers in Child and Adolescent Psychiatry · doi:10.3389/frcha.2022.1056115 · Cited by 9
Majić, T., Jungaberle, H., Schmidt, T. T., Zeuch, A., Hermle, L., & Gallinat, J. (2017) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0043-103085 · Cited by 10
Theranostic pharmacology in PTSD: Neurobiology and timing
Koek, R. J., & Luong, T. N. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.001 · Cited by 10
Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake
Maejima, Y., Horita, S., Otsuka, A., Hidema, S., Nishimori, K., & Shimomura, K. (2020) · Peptides · doi:10.1016/j.peptides.2020.170312 · Cited by 9
Intranasal oxytocin attenuates insula activity in response to dynamic angry faces
Ma, Y., Ran, G., Hu, N., Hu, Y., Long, W., & Chen, X. (2020) · Biological Psychology · doi:10.1016/j.biopsycho.2020.107976 · Cited by 9
Oxytocin and social learning in socially anxious men and women
Flechsenhar, A., Levine, S. M., Müller, L. E., Herpertz, S. C., & Bertsch, K. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109930 · Cited by 8
Maslahati, T., Wingenfeld, K., Hellmann‐Regen, J., Kraft, J., Lyu, J., Keinert, M., Voß, A. L., Cho, A. B., Ripke, S., Otte, C., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02339-z · Cited by 10
Oxytocin modulates neural activity during early perceptual salience attribution
Santiago, A., Kosilo, M., Cogoni, C., Diogo, V. S., Jerónimo, R., & Prata, D. P. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106950 · Cited by 7
Scotland-Coogan, D. (2019) · The Qualitative Report · doi:10.46743/2160-3715/2019.3573 · Cited by 10
Zhang, H., Chen, K., Bao, J., & Wu, H. (2023) · Human Brain Mapping · doi:10.1002/hbm.26498 · Cited by 7
Preclinical behavioral and pharmacological treatments for enhancing fear extinction in adolescence
Wall, E. K., Virakorn, E. A., Baker, K., Cohen, E. M., & Richardson, R. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106090 · Cited by 6
Zhao, W., Zhang, X., & Kendrick, K. M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106624 · Cited by 7
Self-citationUnraveling the role of oxytocin in the motivational structure of conflict
Hurlemann, R., & Marsh, N. (2019) · Behavioral and Brain Sciences · doi:10.1017/s0140525x19000785 · Cited by 6
Self-citationKreutzmann, J. C., & Fendt, M. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100313 · Cited by 6
Editorial: Oxytocin's routes in social behavior: into the 21st century
Andari, E. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00224 · Cited by 5
Hauck, A., Michael, T., Issler, T. C., Klein, S., Lass‐Hennemann, J., & de Sá, D. S. F. (2024) · Behaviour Research and Therapy · doi:10.1016/j.brat.2024.104553 · Cited by 5
Straumann, I., Vizeli, P., Avedisian, I., Erne, L., Noorshams, D., Vukalović, I., Eckert, A., Luethi, D., Rudin, D., & Liechti, M. E. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02248-3 · Cited by 8
Oxytocin Enhancement of Fear Extinction: A New Target for Facilitating Exposure-Based Treatments?
Acheson, D. T., & Risbrough, V. B. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.002 · Cited by 5
Canine Connection Therapy: Finding Purpose and Healing Through the Training of Service Dogs
Olmert, M. D., Nordstrom, M. J., Peters, M., Laurent, M. S., & Yount, R. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-22985-0_14 · Cited by 6
Preckel, K., Trautmann, S., & Kanske, P. (2021) · Clinical Psychology in Europe · doi:10.32872/cpe.3645 · Cited by 5
Self-citationNovel Long-Acting Oxytocin Analog with Increased Efficacy in Reducing Food Intake and Body Weight
Elfers, C., Blevins, J. E., Salameh, T. S., Lawson, E. A., Silva, D., Kiselyov, A. S., & Roth, C. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911249 · Cited by 6
A systematic review of the pharmacological modulation of autobiographical memory specificity
Cawley, E., Piazza, G. G., Das, R., & Kamboj, S. K. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1045217 · Cited by 5
Effects of intranasal oxytocin on fear extinction learning
Rashidi, M., Simon, J. J., Bertsch, K., Wegen, G. V., Ditzen, B., Flor, H., Grinevich, V., Wolf, R. C., & Herpertz, S. C. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01996-y · Cited by 5
Self-citationInfluence of intranasal oxytocin on fear consolidation in healthy humans
Hoge, E. A., Bui, É., Rosencrans, P. L., Orr, S. P., Ross, R., Ojserkis, R. A., & Simon, N. M. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100131 · Cited by 4
Ford, C. L., McDonough, A. A., Horie, K., & Young, L. J. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109848 · Cited by 4
The Perinatal Microbiota-Gut-Brain Axis: Implications for Postpartum Depression
Armbruster, M., & Forsythe, P. (2025) · NeuroImmunoModulation · doi:10.1159/000543691 · Cited by 6
Alcohol Use Disorder and Posttraumatic Stress Disorder: A Relationship Unbonded by Oxytocin Blockade
Vendruscolo, L. F., Lee, M. R., & Leggio, L. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.04.012 · Cited by 3
Behavioral interventions to eliminate fear responses
Yue, J.-L., Shi, L., Lin, X., Khan, M. Z., Shi, J., & Lü, L. (2018) · Science China Life Sciences · doi:10.1007/s11427-018-9294-4 · Cited by 3
Dissecting social decision-making: A spotlight on oxytocinergic transmission
Coccia, G., Greca, F. L., Luca, M. D., & Scheggia, D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1061934 · Cited by 3
Oksitosin ve Psikiyatrik Bozukluklar
Say, G. N., & Müjdeci, M. (2016) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.17749 · Cited by 5
Sozialpsychiatrie und Neurobiologie
Kawohl, W., Wyss, C., Roser, P., Brüne, M., Wulf Rössler, A., & Juckel, G. (2016) · Der Nervenarzt · doi:10.1007/s00115-016-0179-9 · Cited by 2
Lei, Y., Mei, Y., Zhang, W., & Li, H. (2018) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2018.01391 · Cited by 3
Neuropeptidergic systems in psychiatric disorders
Hodzic, S., & Riedemann, T. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1654292 · Cited by 2
Xu, H., LI, Y., Cui, X., Zhang, Y., Wu, X., Zhuo, S. S., He, M., & Xiao, L. (2026) · Science Advances · doi:10.1126/sciadv.aef8400 · Cited by 2
The Function of Oxytocin in Memory —A General Review of Oxytocin’s Effect on Memory
Gao, F. (2023) · World Journal of Neuroscience · doi:10.4236/wjns.2023.134013 · Cited by 2
The complex role of oxytocin in fear acquisition and generalization
Liu, J., Kou, J., Tan, L., Li, H., & Lei, Y. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107421 · Cited by 2
Complex Comorbidity of Substance Use Disorders with Anxiety Disorders: Diagnosis and Treatment
Yılmaz, O., & Dılbaz, N. (2016) · InTech eBooks · doi:10.5772/66247 · Cited by 2
Solomon, D. T., Nietert, P. J., Calhoun, C. D., Smith, D. W., Back, S. E., Barden, E. P., Brady, K. T., & Flanagan, J. C. (2018) · Couple and Family Psychology Research and Practice · doi:10.1037/cfp0000103 · Cited by 2
Translating neuroscience research to oral medicine: oxytocin and human behavior
Nash, D. A. (2015) · Oral Diseases · doi:10.1111/odi.12359 · Cited by 1
Cognitive neural mechanisms underlying the impact of oxytocin on fear acquisition and extinction
Pan, F. E. N. G., Ke, Y. A. N. G., & Tingyong, F. E. N. G. (2021) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2022.00365 · Cited by 1
Oxytocin reduces asymmetries in dominance relationships between pairs of captive female lions
Burkhart, J. C., Guthmann, A., Dubois, E., Heilbronner, S. R., & Packer, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-04276-x · Cited by 1
A systematic review of pharmacological effects on human aversive memory
Xia, Y., Quednow, B. B., & Bach, D. R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106548 · Cited by 1
Guo, X., Zhang, L., Zhang, Q., Kendrick, K. M., & Yao, S. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106679 · Cited by 1
Self-citationOxytocin shapes the priorities and neural representations of attitudes and values
Hurlemann, R., Marsh, N., Schultz, J., & Scheele, D. (2017) · Behavioral and Brain Sciences · doi:10.1017/s0140525x16000807 · Cited by 1
Self-citationNeuroimaging of anxiety disorders
Leicht, G., & Mulert, C. (2020) · doi:10.1093/med/9780198713005.003.0090 · Cited by 1
Mueller, C., Spindler, M., Caspers, S., & Hurlemann, R. (2021) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-86630-3_2 · Cited by 1
Self-citationYuanxiao, M. A., & Xu, C. H. E. N. (2022) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.00010 · Cited by 1
Wichtige physiologische und anatomische Grundlagen
Kindermann, H. (2020) · Springer eBooks · doi:10.1007/978-3-658-28161-8_3 · Cited by 1
Neuromodulatorische Einflüsse auf das Wohlbefinden: Dopamin und Oxytocin
Kirsch, P., & Gruppe, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-53471-7_21 · Cited by 1
Antisocial behaviour in adolescents: exploring and improving emotion processing deficits
Hubble, K. (2015) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 1
Oksitosin ve Psikiyatrik Bozukluklar Oxytocin and Psychiatric Disorders
Say, G. N., & Müjdeci, M. (2016)
Oxytocin and epigenetic mechanisms in mouse models of empathy and autism
Pisansky, M. T. (2016) · University of Minnesota Digital Conservancy (University of Minnesota)
Innovative pharmakologische Strategien gegen Angststörungen
Kiebs, M., & Hurlemann, R. (2018) · NeuroTransmitter · doi:10.1007/s15016-018-6296-x
Self-citationExperimental Medicine Models in Generalized Anxiety Disorder and Social Anxiety Disorder
Baldwin, D. S., & Abou-Aisha, A. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-803161-2.00025-4 · Cited by 1
The modulatory effects of oxytocin on learning and memory: Evidence from animal and human studies
Zhou, M., ZHANG, Y., Gao, S., Keith, M. K., & Yao, S. (2021) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2021.02195
Oxytocin - not only a "social" neuropeptide
Brodmann, K. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5978
Neuromodulatorische Einflüsse auf das Wohlbefinden: Dopamin und Oxytocin
Kirsch, P., & Ditzen, B. (2022) · Psychotherapie: Praxis · doi:10.1007/978-3-662-63821-7_4
Novel Approaches for Treating Anxiety Disorders
Sturman, D. A., Kaufman, M. L., Bigony, C. E., & Ressler, K. J. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0039
Moberg, K. U. (2015) · Springer eBooks · doi:10.1007/978-3-662-47359-7_11
Zhang, H., Chen, K., Bao, J., & Wu, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.23.521846
Metadata
- Authors
- Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T. E., Grinevich, V., Kendrick, K. M., Maier, W., & Hurlemann, R.
- Affiliations
- University of Bonn (DE)
- German Cancer Research Center (DE)
- University of Electronic Science and Technology of China (CN)
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 78
- Issue
- 3
- Pages
- 194-202
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2159597393
- Semantic Scholar
- a0d214dc18ff76b08062d373649a6e6f49fafabf
- Cited by
- 210
- References
- 76
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 10 · 2023: 11 · 2022: 19 · 2021: 16 · 2020: 24 · 2019: 21 · 2018: 25 · 2017: 21 · 2016: 20 · 2015: 23
- FWCI
- 31.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Ministry of Innovation, Science, Research and Technology of the State of North Rhine-Westphalia
- Rheinische Friedrich-Wilhelms-Universität Bonn
- National Natural Science Foundation of China (91132720)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, fear extinction, fear conditioning, amygdala, medial prefrontal cortex, anxiety disorders, skin conductance response, intranasal administration, social fear
- MeSH terms
- Adult, Amygdala, Conditioning, Classical, Double-Blind Method, Fear, Galvanic Skin Response, Humans, Magnetic Resonance Imaging, Male, Oxytocin, Prefrontal Cortex, Young Adult, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
