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Cited by 1,810Pain Mechanisms and TreatmentsNeural and Behavioral Psychology StudiesPain Management and Placebo Effect

Pain and emotion interactions in subregions of the cingulate gyrus

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Vogt, Brent A.·2005·Nature Reviews Neuroscience
DOI 10.1038/nrn1704PMC PMC2659949
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Abstract

Acute pain and emotion are processed in two forebrain networks, and the cingulate cortex is involved in both. Although Brodmann's cingulate gyrus had two divisions and was not based on any functional criteria, functional imaging studies still use this model. However, recent cytoarchitectural studies of the cingulate gyrus support a four-region model, with subregions, that is based on connections and qualitatively unique functions. Although the activity evoked by pain and emotion has been widely reported, some view them as emergent products of the brain rather than of small aggregates of neurons. Here, we assess pain and emotion in each cingulate subregion, and assess whether pain is co-localized with negative affect. Amazingly, these activation patterns do not simply overlap.

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Crossref · 10.1038/nrn1704

Cites

118 of 118 references verified0 citation errors · 0 not checkable

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  • The pregenual and subgenual anterior cingulate cortex have known affective function and are thought to instantiate visceromotor responses observed during classical conditioning, pain, and affective behaviors.

    “The pACC and sACC have known affective function and are thought to instantiate the visceromotor responses observed during classical conditioning, pain, and affective behaviors (Devinksy et al. 1995; Vogt 2005).”

    From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Vogt 2005

    The paper’s discussion of ACC subregions links sACC to autonomic function and classical conditioning, and links both sACC and pACC to affective activity. But it distinguishes their roles in pain: visceral nociceptive activity is associated mainly with pACC, which it says is not an autonomic integrative center like sACC. It therefore does not support attributing the same visceromotor role across classical conditioning, pain, and affective behavior to both subregions. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Pregenual anterior cingulate cortex is implicated in pain, perhaps because it supports the feeling of suffering.

    “Finally, pACC is implicated in pain, perhaps because it supports the feeling of “suffering” (cf. Vogt 2005).”

    From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Vogt 2005

  • Middle and anterior parts of the cingulate cortex are involved in negative affect.

    “which are involved in negative affect (Vogt, 2005)”

    From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Vogt, 2005

  • The pMCC has a hypothesized role in orienting the body toward innocuous and noxious somatosensory stimuli.

    “the hypothesized role of this region in 'orienting the body toward innocuous and noxious somatosensory stimuli' (Vogt, 2005).”

    From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Vogt, 2005

  • Pain intensity ratings were additionally associated with activation in contralateral precentral gyrus, and in dorsal posterior cingulate gyrus in a region involved in visuo-spatial attention.

    “Pain intensity ratings were additionally associated with activation in contralateral precentral gyrus, and in dorsal posterior cingulate gyrus in a region involved in visuo-spatial attention [32].”

    From What are you feeling? Using functional magnetic resonance imaging to assess the modulation of sensory and affective responses during empathy for pain (2007) · cites this paper as [32]

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Cites

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Research works printed but not linked: 3

  1. [1]Aggleton JP. The Amygdala. Oxford University Press; New York: 2001. [Google Scholar]
  2. [39]Villanueva L, Debois C, Le Bars D, Bernard J-F. Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis: A retrograde and anterograde tracer study in the rat. J Comp Neurol. 1998;390:133–160. [PubMed] [Google Scholar]
  3. [40]Bester H, Bourgeais L, Villanueva L, Besson J-M, Bernard J-F. Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: A PHA-L study in the rat. 1999 [PubMed] [Google Scholar]

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Authors
Vogt, B. A.
Affiliations
SUNY Upstate Medical University (US)
Corresponding author
Vogt, Brent A.
ORCID
Vogt, Brent A.
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2005-07
Volume
6
Issue
7
Pages
533-544
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/nrn1704
PMC
PMC2659949
OpenAlex
W2028850601
Cited by
1,810
References
118
Citations by year
2026: 69 · 2025: 77 · 2024: 60 · 2023: 83 · 2022: 78 · 2021: 101 · 2020: 87 · 2019: 88 · 2018: 75 · 2017: 108 · 2016: 100 · 2015: 93 · 2014: 98 · 2013: 109 · 2012: 108
FWCI
7.91
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS044222)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords
cingulate gyrus, pain, emotions, negative affect, Brodmann areas, brain networks, cytoarchitecture
MeSH terms
Animals, Brain Mapping, Emotions, Gyrus Cinguli, Humans, Models, Biological, Neurons, Afferent, Nociceptors, Pain

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