The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain
Abstract
Oxytocin (OT) is a neuropeptide, which can be seen to be one of the molecules of the decade due to its profound prosocial effects in nonvertebrate and vertebrate species, including humans. Although OT can be detected in various physiological fluids (blood, saliva, urine, cerebrospinal fluid) and brain tissue, it is unclear whether peripheral and central OT releases match and synergize. Moreover, the pathways of OT delivery to brain regions involved in specific behaviors are far from clear. Here, we discuss the evolutionarily and ontogenetically determined pathways of OT delivery and OT signaling, which orchestrate activity of the mesolimbic social decision-making network. Furthermore, we speculate that both the alteration in OT delivery and OT receptor expression may cause behavioral abnormalities in patients afflicted with psychosocial diseases.
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“Variations in OXT-related genes like OXTR, as well as DA-related genes, particularly single nucleotide polymorphisms (SNPs), have been linked to social-emotional dysregulation, including aspects of social cognition, empathy, and aggression (Grinevich et al., 2016; Pav lov et al., 2012).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Grinevich et al., 2016
In the citing paper
“Although “isolated” receptors appear to be a common phenomenon in the brain [116], the number of mismatches between the presence of neuropeptides and their receptors may be at least partially the result of a lack of sensitivity of the techniques used to localize neuropeptides [98; 117].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [117]
In the citing paper
“OT is a highly conserved neuro-peptide that modulates reproductive physiology and behavior across bilaterian animals, including nematode worms, rodents, and humans”
From Oxytocin receptors modulate a social salience neural network in male prairie voles (2017) · cites this paper as Grinevich et al., 2016
Citations
Cites
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Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
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Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Evolution of a Vertebrate Social Decision-Making Network
O’Connell, L. A., & Hofmann, H. A. (2012) · Science · doi:10.1126/science.1218889 · Cited by 608
Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
Tyzio, R., Nardou, R., Ferrari, D. C., Tsintsadze, T., Shahrokhi, A., Eftekhari, S., Khalilov, I., Tsintsadze, V., Brouchoud, C., Chazal, G., et al. (2014) · Science · doi:10.1126/science.1247190 · Cited by 601
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Tsukamoto, M., Nagai, L. A., Inoue, K., Kandasamy, L. C., Pires, M. F., Shin, M., Nagasawa, Y., Sambuu, T., Nakai, K., Itohara, S., et al. (2026) · eLife · doi:10.7554/elife.109080
Circuit logic of oxytocin and vasopressin complementary actions
Jeanneteau, F. D., Chakraborty, P., Petitjean, H., & Charlet, A. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1875731
Comparative atlas of PVN oxytocin and vasopressin systems reveals sex-conserved input–output wiring
Freda, S. N., Lowe, Y. F., Priest, M. F., Badong, D., Liu, Y., Xiao, L., & Kozorovitskiy, Y. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536750123
Inada, K. (2026) · Neuroscience Research · doi:10.1016/j.neures.2026.105109
Huang, Y., Liu, Y., Liu, Y., Liang, H., Tong, Y., Li, R., Zhang, X., Wang, Y., Deng, Y., Wu, J., et al. (2026) · Science Advances · doi:10.1126/sciadv.adt4995
魏百慧, Li, X., & Che, X. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107050
Is the oxytocin system a keystone in human wellbeing?
Carter, C. S., & Nazarloo, H. P. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1989082
Metadata
- Authors
- Grinevich, V., Knobloch-Bollmann, H. S., Eliava, M., Busnelli, M., & Chini, B.
- Affiliations
- German Cancer Research Center (DE)
- National Research Council (IT)
- Corresponding author
- Grinevich, Valery
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 79
- Issue
- 3
- Pages
- 155-164
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2040402447
- Cited by
- 309
- References
- 94
- Citations by year
- 2026: 22 · 2025: 15 · 2024: 14 · 2023: 20 · 2022: 29 · 2021: 36 · 2020: 50 · 2019: 22 · 2018: 40 · 2017: 31 · 2016: 24
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, oxytocin signaling, prosocial behavior, psychosocial disorders, ontogeny
- MeSH terms
- Animals, Behavior, Animal, Brain, Humans, Oxytocin, Social Behavior, Signal Transduction, Receptors, Oxytocin
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