Cited by 309Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

Grinevich, Valery, Knobloch-Bollmann, H. Sophie, Eliava, Marina, Busnelli, Marta, Chini, Bice·2016·Biological Psychiatry

DOI 10.1016/j.biopsych.2015.04.013

Open this paper in CoChat — free account

Abstract

Oxytocin (OT) is a neuropeptide, which can be seen to be one of the molecules of the decade due to its profound prosocial effects in nonvertebrate and vertebrate species, including humans. Although OT can be detected in various physiological fluids (blood, saliva, urine, cerebrospinal fluid) and brain tissue, it is unclear whether peripheral and central OT releases match and synergize. Moreover, the pathways of OT delivery to brain regions involved in specific behaviors are far from clear. Here, we discuss the evolutionarily and ontogenetically determined pathways of OT delivery and OT signaling, which orchestrate activity of the mesolimbic social decision-making network. Furthermore, we speculate that both the alteration in OT delivery and OT receptor expression may cause behavioral abnormalities in patients afflicted with psychosocial diseases.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2015.04.013

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Evolution of a Vertebrate Social Decision-Making Network
O’Connell, L. A., & Hofmann, H. A. (2012) · Science · doi:10.1126/science.1218889 · Cited by 608
Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
Tyzio, R., Nardou, R., Ferrari, D. C., Tsintsadze, T., Shahrokhi, A., Eftekhari, S., Khalilov, I., Tsintsadze, V., Brouchoud, C., Chazal, G., et al. (2014) · Science · doi:10.1126/science.1247190 · Cited by 601

Show all 94 references

Sorted by citations

The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing
Eliava, M., Melchior, M., Knobloch-Bollmann, H. S., Wahis, J., da Silva Gouveia, M., Tang, Y., Ciobanu, A. C., Triana del Rio, R., Roth, L. C., Althammer, F., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.041 · Cited by 409
Self-citation
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394
A distributed network for social cognition enriched for oxytocin receptors
Mitre, M., Marlin, B. J., Schiavo, J. K., Morina, E., Norden, S. E., Hackett, T. A., Aoki, C. J., Chao, M. V., & Froemke, R. C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2409-15.2016 · Cited by 305
Biased Oxytocinergic Modulation of Midbrain Dopamine Systems
Xiao, L., Priest, M. F., Nasenbeny, J., Lu, T., & Kozorovitskiy, Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.003 · Cited by 292
What is resilience: an affiliative neuroscience approach
Feldman, R. (2020) · World Psychiatry · doi:10.1002/wps.20729 · Cited by 324
Substance P and pain chronicity
Zieglgänsberger, W. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2922-y · Cited by 283
Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244
Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits
Baribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 241
An Allostatic Theory of Oxytocin
Quintana, D. S., & Guastella, A. J. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.03.008 · Cited by 223
Oxytocin signaling in the lateral septum prevents social fear during lactation
Menon, R., Grund, T., Zoicas, I., Althammer, F., Fiedler, D., Biermeier, V., Bosch, O. J., Hiraoka, Y., Nishimori, K., Eliava, M., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.044 · Cited by 211
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents
Wahis, J., Baudon, A., Althammer, F., Kerspern, D., Goyon, S., Hagiwara, D., Lefèvre, A., Barteczko, L., Boury‐Jamot, B., Bellanger, B., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00800-0 · Cited by 199
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191
Brain oxytocin: how puzzle stones from animal studies translate into psychiatry
Grinevich, V., & Neumann, I. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0802-9 · Cited by 201
Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles
Johnson, Z. V., Walum, H., Jamal, Y. A., Xiao, Y., Keebaugh, A. C., Inoue, K., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.11.011 · Cited by 190
Challenges for measuring oxytocin: the blind men and the elephant?
MacLean, E. L., Wilson, S. R., Martin, W. L., Davis, J. M., Nazarloo, H. P., & Carter, C. S. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.018 · Cited by 183
Conditional deletion of hippocampal CA2/CA3a oxytocin receptors impairs the persistence of long-term social recognition memory in mice
Lin, Y.-T., Hsieh, T.-Y., Tsai, T.-C., Chen, C.-C., Huang, C.-C., & Hsu, K.-S. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1896-17.2017 · Cited by 165
Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know
Busnelli, M., & Chini, B. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_6 · Cited by 168
The Oxytocin–Vasopressin Pathway in the Context of Love and Fear
Carter, C. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00356 · Cited by 170
Oxytocin receptors are expressed on dopamine and glutamate neurons in the mouse ventral tegmental area that project to nucleus accumbens and other mesolimbic targets
Peris, J., MacFadyen, K. A., Smith, J. A., de Kloet, A. D., Wang, L. A., & Krause, E. G. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24116 · Cited by 158
Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis
Rutigliano, G., Rocchetti, M., Paloyelis, Y., Gilleen, J., Sardella, A., Cappucciati, M., Palombini, E., Dell’Osso, L., Caverzasi, E., Politi, P., et al. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.117 · Cited by 149
“…authors, about the lack of neurophysiological evidence of a direct relationship between peripheral levels of OT and ADH and their central release and activity (Grinevich et al., 2015; Kagerbauer et al., 2013; Leng and Ludwig, 2015; Ludwig and Leng, 2006; McCullough et al., 2013; Neumann, 2007).”
Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
Lin, Y.-T., Chen, C., Huang, C., Nishimori, K., & Hsu, K. (2017) · Nature Communications · doi:10.1038/s41467-017-00675-5 · Cited by 149
Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139
Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance
Duque-Wilckens, N., Torres, L. Y., Yokoyama, S., Minie, V. A., Tran, A. M., Petkova, S. P., Hao, R., Ramos-Maciel, S., Rios, R. A., Jackson, K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011890117 · Cited by 139
Self-citation
Oxytocin and Pain Perception: From Animal Models to Human Research
Boll, S., de Minas, A. C. A., Raftogianni, A., Herpertz, S. C., & Grinevich, V. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.041 · Cited by 141
The interplay between oxytocin and the CRF system: regulation of the stress response
Winter, J. J., & Jurek, B. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2866-2 · Cited by 145
Diversity of oxytocin neurones: Beyond magno‐ and parvocellular cell types?
Althammer, F., & Grinevich, V. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12549 · Cited by 138
The Sensitivity to Threat and Affiliative Reward (STAR) model and the development of callous-unemotional traits
Waller, R. E., & Wagner, N. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.005 · Cited by 148
Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., & Leggio, L. (2020) · Nature Communications · doi:10.1038/s41467-020-15942-1 · Cited by 132
Whole-brain wiring diagram of oxytocin system in adult mice
Son, S., Manjila, S. B., Newmaster, K. T., Wu, Y.-T., Vanselow, D. J., Ciarletta, M., Anthony, T. E., Cheng, K. C., & Kim, Y. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.0307-22.2022 · Cited by 125
The Role of the Central Amygdala in Alcohol Dependence
Roberto, M., Kirson, D., & Khom, S. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039339 · Cited by 112
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121
Oxytocin receptors modulate a social salience neural network in male prairie voles
Johnson, Z. V., Walum, H., Xiao, Y., Riefkohl, P. C., & Young, L. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.10.009 · Cited by 113
Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans
Hansson, A. C., Koopmann, A., Uhrig, S., Bühler, S., Domi, E., Kiessling, E., Ciccocioppo, R., Froemke, R. C., Grinevich, V., Kiefer, F., et al. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.257 · Cited by 109
Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains
Newmaster, K. T., Nolan, Z. T., Chon, U., Vanselow, D. J., Weit, A. R., Tabbaa, M., Hidema, S., Nishimori, K., Hammock, E. A. D., & Kim, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-15659-1 · Cited by 115
Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala
Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., et al. (2019) · PLOS Biology · doi:10.1371/journal.pbio.2006421 · Cited by 104
Social Decision-Making and the Brain: A Comparative Perspective
Tremblay, S., Sharika, K. M., & Platt, M. L. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.007 · Cited by 116
The Role of Oxytocin and Vasopressin in Attachment
Carter, C. S. (2017) · Psychodynamic Psychiatry · doi:10.1521/pdps.2017.45.4.499 · Cited by 105
Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation
Ellis, B. J., Horn, A. J., Carter, C. S., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.101985 · Cited by 103
RAGE regulates oxytocin transport into the brain
Yamamoto, Y., & Higashida, H. (2020) · Communications Biology · doi:10.1038/s42003-020-0799-2 · Cited by 109
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100
Oxytocin receptor signaling in the hippocampus: Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory
Lin, Y.-T., & Hsu, K. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.10.003 · Cited by 102
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 104
Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity
Wang, P., Yang, H.-P., Tian, S., Wang, L., Wang, S. C., Zhang, F., & Wang, Y. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.11.001 · Cited by 96
Oxytocin – The Sweet Hormone?
Leng, G., & Sabatier, N. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.02.007 · Cited by 90
Links between the neurobiology of oxytocin and human musicality
Harvey, A. R. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00350 · Cited by 85
Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition
Plasencia, G., Luedicke, J., Pournajafi‐Nazarloo, H., Carter, C. S., & Ebner, N. C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104419 · Cited by 87
The Monogamy Paradox: What Do Love and Sex Have to Do With It?
Carter, C. S., & Perkeybile, A. M. (2018) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2018.00202 · Cited by 87
The analgesic effects of oxytocin in the peripheral and central nervous system
Xin, Q., Bai, B., & Liu, W. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.021 · Cited by 81
Oxytocin Modulation of Neural Circuits
Mitre, M., Minder, J. L., Morina, E., Chao, M. V., & Froemke, R. C. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_7 · Cited by 79
Psychobiology of Attachment and Trauma—Some General Remarks From a Clinical Perspective
Lahousen, T., Unterrainer, ., & Kapfhammer, H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00914 · Cited by 83
The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders
Abramova, O. V., Zorkina, Y., Ushakova, V. M., Zubkov, E. A., Morozova, A. Y., & Chekhonin, V. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102079 · Cited by 75
Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain
Liu, Y., Li, A., Bair-Marshall, C. J., Xu, H. Z., Jee, H. J., Zhu, E., Sun, M., Zhang, Q., Lefèvre, A., Chen, Z. S., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.014 · Cited by 77
The Parental Brain
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 106
Lifespan oxytocin signaling: Maturation, flexibility, and stability in newborn, adolescent, and aged brain
Sannino, S., Chini, B., & Grinevich, V. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22450 · Cited by 72
Neuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66
The role of oxytocin in alcohol and drug abuse
King, C. E., Gano, A., & Becker, H. C. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146761 · Cited by 69
Oxytocin–Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice
Nasanbuyan, N., Yoshida, M., Takayanagi, Y., Inutsuka, A., Nishimori, K., Yamanaka, A., & Onaka, T. (2017) · Endocrinology · doi:10.1210/en.2017-00606 · Cited by 70
Chronic Postnatal Stress Induces Depressive-like Behavior in Male Mice and Programs second-Hit Stress-Induced Gene Expression Patterns of OxtR and AvpR1a in Adulthood
Lesse, A., Rether, K., Gröger, N., Braun, K., & Bock, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0043-8 · Cited by 66
Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
Dobolyi, A., Cservenák, M., & Young, L. J. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.002 · Cited by 64
A thalamo-hypothalamic pathway that activates oxytocin neurons in social contexts in female rats
Cservenák, M., Keller, D., Kis, V., Fazekas, E. A., Öllös, H., Lékó, A. H., Szabó, É. R., Renner, É., Usdin, T. B., Palkovits, M., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1645 · Cited by 64
Targeting the Oxytocin System: New Pharmacotherapeutic Approaches
Gulliver, D. W., Werry, E. L., Reekie, T. A., Katte, T. A., Jorgensen, W. T., & Kassiou, M. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.11.001 · Cited by 67
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107602 · Cited by 61
Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats
Kohli, S., King, M. V., Williams, S. A., Edwards, A., Ballard, T. M., Steward, L. J., Alberati, D., & Fone, K. C. F. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0171-0 · Cited by 61
The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine
Warfvinge, K., Krause, D. N., & Edvinsson, L. I. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-1079-8 · Cited by 60
Oxytocin and love: myths, metaphors and mysteries.
Carter, C. S. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100107 · Cited by 57
Intimacy as Related to Cortisol Reactivity and Recovery in Couples Undergoing Psychosocial Stress
Ditzen, B., Germann, J., Meuwly, N., Bradbury, T. N., Bodenmann, G., & Heinrichs, M. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000633 · Cited by 62
LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism
Frantz, M., Pellissier, L. P., Pflimlin, E., Loison, S., Gandía, J., MARSOL, C., Durroux, T., Mouillac, B., Becker, J. A. J., Merrer, J. L., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00697 · Cited by 58
Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences
Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenländer, L., Neumann, I. D., & Grinevich, V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.019 · Cited by 53
Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders
Rajamani, K. T., Wagner, S., Grinevich, V., & Harony-Nicolas, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00017 · Cited by 53
Methylenedioxymethamphetamine (MDMA) in Psychiatry
Schenk, S., & Newcombe, D. A. L. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000962 · Cited by 53
Intranasal oxytocin administration promotes emotional contagion and reduces aggression in a mouse model of callousness
Zoratto, F., Sbriccoli, M., Martinelli, A., Glennon, J. C., Macrı̀, S., & Laviola, G. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.010 · Cited by 53
Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance
Ateş, T., Öncül, M., Dilsiz, P., Topcu, I. C., Cıvaş, C. C., Alp, M. İ., Aklan, İ., Öz, E. A., Yavuz, Y., Yılmaz, B., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.017 · Cited by 51
Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51
“Variations in OXT-related genes like OXTR, as well as DA-related genes, particularly single nucleotide polymorphisms (SNPs), have been linked to social-emotional dysregulation, including aspects of social cognition, empathy, and aggression (Grinevich et al., 2016; Pav-lov et al., 2012).”
Background
Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory
Higashida, H. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0425-0 · Cited by 49
Using imputed whole-genome sequence variants to uncover candidate mutations and genes affecting milking speed and temperament in Holstein cattle
Chen, S., de Oliveira, H. R., Schenkel, F. S., Pedrosa, V. B., Melka, M. G., & Brito, L. F. (2020) · Journal of Dairy Science · doi:10.3168/jds.2020-18897 · Cited by 48
Developmental effects of oxytocin neurons on social affiliation and processing of social information
Nunes, A. R., Gliksberg, M., Varela, S. A. M., Teles, M., Wircer, E., Blechman, J., Petri, G., Levkowitz, G., & Oliveira, R. F. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2939-20.2021 · Cited by 47
How do hypothalamic nonapeptides shape youth’s sociality? A systematic review on oxytocin, vasopressin and human socio-emotional development
Torres, N., Martins, D., dos Santos, A. J., Prata, D. P., & Veríssimo, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.004 · Cited by 51
Convergent neuroendocrine mechanisms of social buffering and stress contagion
Peen, N. F., Duque‐Wilckens, N., & Trainor, B. C. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.104933 · Cited by 46
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model
Tabbaa, M., Paedae, B., Liu, Y., & Wang, Z. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150055 · Cited by 53
An oxytocin-dependent social interaction between larvae and adult C. elegans
Scott, E., Hudson, A., Feist, E., Calahorro, F., Dillon, J., de Freitas, R., Wand, M. E., Schoofs, L., O'Connor, V. M., & Holden-Dye, L. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-09350-7 · Cited by 42
Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions
Baudon, A., Creusot, E. C., Althammer, F., Schaaf, C. P., & Charlet, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102328 · Cited by 44
Oxytocin Receptor Signaling in Vascular Function and Stroke
McKay, E. C., & Counts, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.574499 · Cited by 45
Oxytocin depolarizes fast-spiking hilar interneurons and induces GABA release onto mossy cells of the rat dentate gyrus
Harden, S. W., & Frazier, C. J. (2016) · Hippocampus · doi:10.1002/hipo.22595 · Cited by 44
“Less is more”: A dose-response account of intranasal oxytocin pharmacodynamics in the human brain
Martins, D., Brodmann, K., Veronese, M., Dipasquale, O., Mazibuko, N., Schuschnig, U., Zelaya, F. O., Fotopoulou, A., & Paloyelis, Y. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102239 · Cited by 43
Understanding the Oxytocin System and Its Relevance to Psychiatry
Shamay‐Tsoory, S., & Young, L. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.014 · Cited by 39
Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists
Cid-Jofré, V., Moreno, M., Reyes-Parada, M. I., & Renard, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112077 · Cited by 40
Neural circuit control of innate behaviors
Wei, X., Jiao, Z., Senol, E., Yao, J., Zhao, M., Zhao, Z., Chen, X., Cao, P., Fu, Y., Gao, Z., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2043-2 · Cited by 40
Oxytocin and Sensory Network Plasticity
Pekarek, B. T., Hunt, P. J., & Arenkiel, B. R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00030 · Cited by 40
DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders
Siu, M. T., Goodman, S. J., Yellan, I., Butcher, D. T., Jangjoo, M., Grafodatskaya, D., Rajendram, R., Lou, Y., Zhang, R., Zhao, C., et al. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04792-x · Cited by 38
Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction
Goh, K. K., Chen, C. Y.-A., Wu, T., Chen, C.-H., & Lu, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137092 · Cited by 41
The oxytocin system of mice and men—Similarities and discrepancies of oxytocinergic modulation in rodents and primates
Althammer, F., Jirikowski, G. F., & Grinevich, V. (2018) · Peptides · doi:10.1016/j.peptides.2018.09.003 · Cited by 35
Intertwined associations between oxytocin, immune system and major depressive disorder
Jiang, J., Yang, M., Tian, M., Chen, Z., Xiao, L., & Gong, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114852 · Cited by 40
Oxytocin receptor gene variation rs53576 and alcohol abuse in a longitudinal population representative study
Vaht, M., Kurrikoff, T., Laas, K., Veidebaum, T., & Harro, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.018 · Cited by 39
Interplay between the oxytocin and opioid systems in regulating social behaviour
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0050 · Cited by 33
Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders
Towers, A. J., Tremblay, M. W., Chung, L., Li, X.-L., Bey, A. L., Zhang, W., Cao, X., Wang, X., Wang, P., Duffney, L. J., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120592 · Cited by 31
Oxytocin release deficit and social cognition in craniopharyngioma patients
Brandi, M., Gebert, D., Kopczak, A., Auer, M. K., & Schilbach, L. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12842 · Cited by 33
Oxytocin-based therapies for treatment of Prader-Willi and Schaaf-Yang syndromes: evidence, disappointments, and future research strategies
Althammer, F., Muscatelli, F., Grinevich, V., & Schaaf, C. P. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02054-1 · Cited by 35
Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin
Bardo, M. T., Hammerslag, L. R., & Malone, S. G. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108567 · Cited by 32
Oxytocin and Steroid Actions
Jirikowski, G. F., Ochs, S. D., & Caldwell, J. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_9 · Cited by 32

Authors: Grinevich, V., Knobloch-Bollmann, H. S., Eliava, M., Busnelli, M., & Chini, B.
Affiliations: German Cancer Research Center (DE)
National Research Council (IT)
Corresponding author: Grinevich, Valery
ORCID: Grinevich, Valery
Busnelli, Marta
Chini, Bice
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2016-02
Volume: 79
Issue: 3
Pages: 155-164
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2015.04.013
OpenAlex: W2040402447
Cited by: 309
References: 94
Citations by year: 2026: 22 · 2025: 15 · 2024: 14 · 2023: 20 · 2022: 29 · 2021: 36 · 2020: 50 · 2019: 22 · 2018: 40 · 2017: 31 · 2016: 24
FWCI: 5.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin, oxytocin signaling, prosocial behavior, psychosocial disorders, ontogeny
MeSH terms: Animals, Behavior, Animal, Brain, Humans, Oxytocin, Social Behavior, Signal Transduction, Receptors, Oxytocin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks