Cited by 262Autism Spectrum Disorder ResearchTryptophan and brain disordersGenetics and Neurodevelopmental Disorders

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Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder

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Krakowiak, Paula, Goines, Paula E., Tancredi, Daniel J., Ashwood, Paul, Hansen, Robin L., Hertz-Picciotto, Irva, Van de Water, Judy·2017·Biological Psychiatry

DOI 10.1016/j.biopsych.2015.08.007PMC PMC4753133

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Abstract

Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that can be reliably diagnosed at age 24 months. Immunological phenomena, including skewed cytokine production, have been observed among children with ASD. Little is known about whether immune dysregulation is present before diagnosis of ASD.Methods We examined neonatal blood spots from 214 children with ASD (141 severe, 73 mild/moderate), 62 children with typical development, and 27 children with developmental delay as control subjects who participated in the Childhood Autism Risks from Genetics and the Environment study, a population-based case-control study. Levels of 17 cytokines and chemokines were compared across groups and in relation to developmental and behavioral domains.Results Interleukin (IL)-1β and IL-4 were independently associated with ASD compared with typical development, although these relationships varied by ASD symptom intensity. Elevated IL-4 was associated with increased odds of severe ASD (odds ratio [OR] = 1.40, 95% confidence interval [CI], 1.03, 1.91), whereas IL-1β was associated with increased odds of mild/moderate ASD (OR = 3.02, 95% CI, 1.43, 6.38). Additionally, IL-4 was associated with a higher likelihood of severe ASD versus mild/moderate ASD (OR = 1.35, 95% CI, 1.04, 1.75). In male subjects with ASD, IL-4 was negatively associated with nonverbal cognitive ability (β = -3.63, SE = 1.33, p = .04).Conclusions This study is part of a growing effort to identify early biological markers for ASD. We demonstrate that peripheral cytokine profiles at birth are associated with ASD later in childhood and that cytokine profiles vary depending on ASD severity. Cytokines have complex roles in neurodevelopment, and dysregulated levels may be indicative of genetic differences and environmental exposures or their interactions that relate to ASD.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · cited 1×
“The Benjamini-Hochberg procedure was used to correct p values for multiple comparisons (16 biomarkers) (31).”
Method
Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · cited 5×
“The 276 participants comprised the following groups: 141 with g Autism Diagnostic Observation Schedule comparison scores, where s. was augmented when we examined male case subjects only (Figure S3 and Table S6 in Supplement 1).”
MethodInfluential
International Statistical Classification of Diseases and Related Health Problems
Eisfeld, J. (2014) · TSQ Transgender Studies Quarterly · doi:10.1215/23289252-2399740 · Cited by 3,570
Mullen Scales of Early Learning
Bradley‐Johnson, S. (1997) · Psychology in the Schools · doi:10.1002/(sici)1520-6807(199710)34:4 · Cited by 2,329
Autism Diagnostic Observation Schedule
Lord, C., Rutter, M. L., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989) · PsycTESTS Dataset · doi:10.1037/t54175-000 · Cited by 1,697
Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940
Self-citation
Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.006 · Cited by 923
Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862
Early Behavioral Intervention Is Associated With Normalized Brain Activity in Young Children With Autism
Dawson, G., Jones, E. J. H., Merkle, K., Venema, K., Lowy, R., Faja, S., Kamara, D., Murias, M., Greenson, J., Winter, J., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.018 · Cited by 799 · cited 1×
“The most consistently beneficial treatment for ASD is behavioral therapy, which is most effective when administered early in life (8).”
Background
Combining Information From Multiple Sources in the Diagnosis of Autism Spectrum Disorders
RISI, S., LORD, C., GOTHAM, K., CORSELLO, C., CHRYSLER, C., SZATMARI, P., COOK, E. H., LEVENTHAL, B. L., & PICKLES, A. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000227880.42780.0e · Cited by 581
Autism Spectrum Disorders
Lord, C., Cook, E. H., Leventhal, B. L., & Amaral, D. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)00115-x · Cited by 555
Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.
Banks, W. A., Ortiz, L., Plotkin, S. R., & Kastin, A. J. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20576-6 · Cited by 474
Autism Diagnostic Observation Schedule
Carr, T. (2013) · Springer eBooks · doi:10.1007/978-1-4419-1698-3_896 · Cited by 451
The CHARGE Study: An Epidemiologic Investigation of Genetic and Environmental Factors Contributing to Autism
Hertz‐Picciotto, I., Croen, L., Hansen, R. L., Jones, C. R., de Water, J. V., & Pessah, I. N. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8483 · Cited by 427
Self-citation
Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression
Jyonouchi, H., Sun, S., & Le, H. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00421-0 · Cited by 396
Transfer of Inflammatory Cytokines Across the Placenta
Zaretsky, M. V., Alexander, J. M., Byrd, W., & Bawdon, R. E. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000114980.40445.83 · Cited by 376 · cited 1×
“We assume most of the analytes we measured to be of neonatal origin because maternal cytokines and chemokines are largely blocked from placental passage, with the possible exception of IL-6 and granulocyte-macrophage colony-stimulating factor (33,34).”
Background
Maternal Autoimmune Diseases, Asthma and Allergies, and Childhood Autism Spectrum Disorders
Croen, L., Grether, J. K., Yoshida, C. K., Odouli, R., & de Water, J. V. (2005) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.159.2.151 · Cited by 373 · cited 1×
“More subtly, maternal atopic disorders such as asthma and allergy as well as increased IL-4 and IFN-γ during pregnancy have been shown to be associated with an increased risk of ASD (10,66,67).”
Background
Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
Herbert, M. R. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336a01f · Cited by 356 · cited 1×
“The biological basis of ASD is unclear but likely involves a complex interplay between genetic susceptibility and environmental exposures (4).”
Background
Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study
Goines, P. E., Croen, L. A., Braunschweig, D., Yoshida, C. K., Grether, J., Hansen, R., Kharrazi, M., Ashwood, P., & Van de Water, J. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-13 · Cited by 351
Self-citation
Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314
Self-citation
Differential monocyte responses to TLR ligands in children with autism spectrum disorders
Enstrom, A. M., Onore, C. E., Van de Water, J. A., & Ashwood, P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.08.001 · Cited by 294
Self-citation
Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells
Zaghouani, H., Hoeman, C. M., & Adkins, B. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.002 · Cited by 264 · cited 1×
“an inflammatory Th1 phenotype) compared with adults (60,61).”
Background
Simultaneous Measurement of 25 Inflammatory Markers and Neurotrophins in Neonatal Dried Blood Spots by Immunoassay with xMAP Technology
Skogstrand, K., Thorsen, P., Nørgaard‐Pedersen, B., Schendel, D., Sørensen, L. C., & HOUGAARD, D. M. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.052241 · Cited by 262 · cited 1×
“Neonatal blood spots were used to measure cytokine profiles in several studies (35,36) and to identify immune markers for various disorders, including type 1 diabetes (37), toxoplasmosis (38), Down syndrome, and ASD (18–20,39).”
Method
Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders
Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Yoshihara, Y., Wakuda, T., Takebayashi, K., Takagai, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020470 · Cited by 252
Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors
Araujo, D. M., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90400-h · Cited by 237
Low-grade endotoxemia in patients with severe autism
Emanuele, E., Orsi, P., Boso, M., Broglia, D., Brondino, N., Barale, F., di Nemi, S. U., & Politi, P. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.033 · Cited by 225
Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus
Nolan, Y. M., Maher, F. O., Martin, D. S. D., Clarke, R. M., Brady, M. T., Bolton, A. E., Mills, K. H. G., & Lynch, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412170200 · Cited by 210
Mutations in the calcium-related gene IL1RAPL1 are associated with autism
Piton, A., Michaud, J. L., Peng, H., Aradhya, S., Gauthier, J., Mottron, L., Champagne, N., Lafreniere, R. G., Hamdan, F. F., S2D team, et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn300 · Cited by 195
Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders
Abdallah, M. W., Larsen, N., Grove, J., Nørgaard-Pedersen, B., Thorsen, P., Mortensen, E. L., & Hougaard, D. M. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.639803 · Cited by 186 · cited 1×
“Elevated IL-4 has also been linked to ASD with increased levels reported in maternal serum during the second trimester of pregnancy (9) and in amniotic fluid (59) collected from mothers who gave birth to children in whom ASD was later diagnosed.”
Background
Diagnosing Autism Spectrum Disorders in Pre-school Children Using Two Standardised Assessment Instruments: The ADI-R and the ADOS
Le Couteur, A., Haden, G., Hammal, D., & McConachie, H. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0403-3 · Cited by 181
Maternal Mid-Pregnancy Autoantibodies to Fetal Brain Protein: The Early Markers for Autism Study
Croen, L., Braunschweig, D., Haapanen, L. A. D., Yoshida, C. K., FIREMAN, B. H., Grether, J. K., Kharrazi, M., Hansen, R. L., Ashwood, P., & de Water, J. V. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.006 · Cited by 171 · cited 1×
“More subtly, maternal atopic disorders such as asthma and allergy as well as increased IL-4 and IFN-γ during pregnancy have been shown to be associated with an increased risk of ASD (10,66,67).”
BackgroundSelf-citation
Immune Dysfunction in Autism: A Pathway to Treatment
Careaga, M., de Water, J. V., & Ashwood, P. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.003 · Cited by 166
Self-citation
Expression of cytokine receptors in cultured neuronal and glial cells
Sawada, M., Itoh, Y., Suzumura, A., & Marunouchi, T. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90396-3 · Cited by 160
Murine Neonatal CD4+ Cells Are Poised for Rapid Th2 Effector-Like Function
Rose, S. M., Lichtenheld, M. G., Foote, M. R., & Adkins, B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2667 · Cited by 148
Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome
Nelson, P. G., Kuddo, T., Song, E. Y., Dambrosia, J. M., Kohler, S. J., Satyanarayana, G., VanDunk, C., Grether, J. K., & Nelson, K. B. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.10.003 · Cited by 144 · cited 1×
“(39) measured cytokine levels in neonatal blood spots from children with ASD; only IL-8 was within the detectable range.”
Background
Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples
Skogstrand, K., Ekelund, C. K., Thorsen, P., Vogel, I., Jacobsson, B., Nørgaard‐Pedersen, B., & HOUGAARD, D. M. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.04.006 · Cited by 134 · cited 1×
“Neonatal blood spots were used to measure cytokine profiles in several studies (35,36) and to identify immune markers for various disorders, including type 1 diabetes (37), toxoplasmosis (38), Down syndrome, and ASD (18–20,39).”
Method
Autoantibodies to cerebellum in children with autism associate with behavior
Goines, P., Haapanen, L., Boyce, R., Duncanson, P., Braunschweig, D., Delwiche, L., Hansen, R., Hertz-Picciotto, I., Ashwood, P., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.11.017 · Cited by 134
Self-citation
Antibrain antibodies in children with autism and their unaffected siblings
Singer, H. S., Morris, C. M., Williams, P. N., Yoon, D. Y., Hong, J. J., & Zimmerman, A. W. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.05.025 · Cited by 132
Polymorphisms of the interleukin-1 gene complex in schizophrenia
Katila, H., Hänninen, K., & Hurme, M. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000483 · Cited by 123
Cytokine network in the central nervous system and its roles in growth and differentiation of glial and neuronal cells
Sawada, M., Suzumura, A., & Marunouchi, T. (1995) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(94)00076-f · Cited by 119
Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study
Zerbo, O., Yoshida, C. K., Grether, J. K., de Water, J. V., Ashwood, P., DeLorenze, G. N., Hansen, R. L., Kharrazi, M., & Croen, L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-113 · Cited by 116 · cited 2×
“(20) had limitations similar to the Abdallah et al.”
BackgroundSelf-citation
Newborn Screening for Congenital Infectious Diseases
Neto, E. C., Rubin, R., Schulte, J., & Giugliani, R. (2004) · Emerging infectious diseases · doi:10.3201/eid1006.030830 · Cited by 103 · cited 1×
“Neonatal blood spots were used to measure cytokine profiles in several studies (35,36) and to identify immune markers for various disorders, including type 1 diabetes (37), toxoplasmosis (38), Down syndrome, and ASD (18–20,39).”
Method
Autoantibodies in Autism Spectrum Disorders (ASD)
Wills, S., Cabanlit, M., BENNETT, J., Ashwood, P., Amaral, D. G., & de Water, J. V. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.009 · Cited by 100
Self-citation
Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank
Abdallah, M. W., Larsen, N., Mortensen, E. L., Atladóttir, H. Ó., Nørgaard-Pedersen, B., Bonefeld-Jørgensen, E. C., Grove, J., & Hougaard, D. M. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.07.013 · Cited by 94 · cited 2×
“(18,19) found decreased levels of many cytokines (i.”
Background
Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
Lyall, K., Ashwood, P., de Water, J. V., & Hertz‐Picciotto, I. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-2017-2 · Cited by 93 · cited 1×
“More subtly, maternal atopic disorders such as asthma and allergy as well as increased IL-4 and IFN-γ during pregnancy have been shown to be associated with an increased risk of ASD (10,66,67).”
BackgroundSelf-citation
POSSIBLE CORRELATION BETWEEN HIGH LEVELS OF IL-18 IN THE CORD BLOOD OF PRE-TERM INFANTS AND NEONATAL DEVELOPMENT OF PERIVENTRICULAR LEUKOMALACIA AND CEREBRAL PALSY
Minagawa, K., Tsuji, Y., Ueda, H., Koyama, K., Tanizawa, K., Okamura, H., & Hashimoto-Tamaoki, T. (2002) · Cytokine · doi:10.1006/cyto.2001.0988 · Cited by 82
The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents
Jaspan, H. B., Lawn, S. D., Safrit, J. T., & Bekker, L. (2006) · AIDS · doi:10.1097/01.aids.0000210602.40267.60 · Cited by 81 · cited 1×
“The neonatal immune system is extremely immature, and cytokine production is much lower than in adults (32); this was accurately reflected by the number of subjects whose wholeblood cytokine levels were near or below the limit of detection.”
Background
Integrated Review of Cytokines in Maternal, Cord, and Newborn Blood: Part I—Associations With Preterm Birth
Lyon, D., Cheng, C., Howland, L. C., Rattican, D., Jallo, N., Pickler, R. H., Brown, L., & McGrath, J. M. (2009) · Biological Research For Nursing · doi:10.1177/1099800409344620 · Cited by 80
Structural and Functional Deficits in a Neuronal Calcium Sensor-1 Mutant Identified in a Case of Autistic Spectrum Disorder
Handley, M. T., Lian, L., Haynes, L. P., & Burgoyne, R. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010534 · Cited by 70
Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders
Onore, C. E., Enstrom, A. M., Krakowiak, P., Hertz‐Picciotto, I., Hansen, R., de Water, J. V., & Ashwood, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.09.005 · Cited by 69
Self-citation
Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study
Abdallah, M. W., Larsen, N., Grove, J., Bonefeld‐Jørgensen, E. C., Nørgaard‐Pedersen, B., HOUGAARD, D. M., & Mortensen, E. L. (2012) · Cytokine · doi:10.1016/j.cyto.2012.11.015 · Cited by 62 · cited 1×
“(18,19) found decreased levels of many cytokines (i.”
Background
Association of Preterm Birth With Sustained Postnatal Inflammatory Response
Skogstrand, K., HOUGAARD, D. M., Schendel, D., Nørgaard‐Pedersen, B., Sværke, C., & Thorsen, P. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31817057fb · Cited by 55
Neuronal Cell Survival
Giestal‐de‐Araujo, E., da Silva, G. M., & dos Santos, A. A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03974.x · Cited by 46
Aberrant Behavior Checklist – Community
(2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_300021 · Cited by 42
Type 1 diabetes risk analysis on dried blood spot samples from population‐based newborns: design and feasibility of an unselected case–control study
Eising, S., Svensson, J., Skogstrand, K., Nilsson, A., Lynch, K. F., Andersen, P. S., Lernmark, Å., HOUGAARD, D. M., Pociot, F., Nørgaard‐Pedersen, B., et al. (2007) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2007.00846.x · Cited by 38 · cited 1×
“Neonatal blood spots were used to measure cytokine profiles in several studies (35,36) and to identify immune markers for various disorders, including type 1 diabetes (37), toxoplasmosis (38), Down syndrome, and ASD (18–20,39).”
Method
Integrated Review of Cytokines in Maternal, Cord, and Newborn Blood: Part II— Associations With Early Infection and Increased Risk of Neurologic Damage in Preterm Infants
Pickler, R. H., Brown, L., McGrath, J. M., Lyon, D., Rattican, D., Cheng, C., Howland, L. C., & Jallo, N. (2009) · Biological Research For Nursing · doi:10.1177/1099800409344619 · Cited by 36
Developmentally regulated gene expression of Th2 cytokines in the brain
Lovett‐Racke, A. E., Smith, M. E., Arredondo, L. R., Bittner, P., Ratts, R. B., Shive, C. L., Forsthuber, T. G., & Racke, M. K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02398-2 · Cited by 23
Interleukin-4 blocks proliferation of retinal progenitor cells and increases rod photoreceptor differentiation through distinct signaling pathways
da Silva, A. G. L. S., Campello‐Costa, P., Linden, R., & Sholl‐Franco, A. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.03.003 · Cited by 22
IL-4 increases GABAergic phenotype in rat retinal cell cultures: involvement of muscarinic receptors and protein kinase C
Sholl‐Franco, A., Marques, P. M. B., Ferreira, C. M. C., & Giestal‐de‐Araujo, E. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00327-2 · Cited by 20
California Very Preterm Birth Study: design and characteristics of the population‐ and biospecimen bank‐based nested case–control study
Kharrazi, M., Pearl, M., Yang, J., DeLorenze, G. N., Bean, C. J., Callaghan, W. M., Grant, A. M., Lackritz, E., Romero, R. J., Satten, G. A., et al. (2012) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2011.01252.x · Cited by 17 · cited 2×
“ARTICLE INFORMATION From the Divisions of Epidemiology and of Environmental and Occupational Health (PK, IH-P), Department of Public Health Sciences, Division of Rheumatology, Allergy and Clinical Immunology (PEG, JVdW), Department of Internal Medicine, Department of Pediatrics (DJT, RLH), and Department of Medical Mi…”
Background
The passage of granulocyte-macrophage colony-stimulating factor across the human placenta perfused in vitro
Gregor, H. (1999) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(99)00042-8 · Cited by 16
Exogenous IL-1beta induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA axis and prolactin release.
Škurlová, M., Štofková, A., & Jur̀čovičová, J. (2006) · PubMed · Cited by 11

Research works printed but not linked: 1

Kabacoff RI (2003): Determining the dimensionality of data: A SAS macro for parallel analysis. In: SAS Institute Inc. Proceedings of the Twenty Eighth Annual SAS Users Group International (SUGI 28). Cary, NC: SAS Institute Inc.

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Authors: Krakowiak, P., Goines, P. E., Tancredi, D. J., Ashwood, P., Hansen, R. L., Hertz-Picciotto, I., & Van de Water, J.
Affiliations: University of California, Davis (US)
ORCID: Krakowiak, Paula
Tancredi, Daniel J.
Ashwood, Paul
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2017-03
Volume: 81
Issue: 5
Pages: 442-451
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2015.08.007
PMC: PMC4753133
OpenAlex: W1409858176
Cited by: 249
References: 65
Citations by year: 2026: 15 · 2025: 14 · 2024: 34 · 2023: 32 · 2022: 35 · 2021: 16 · 2020: 27 · 2019: 26 · 2018: 28 · 2017: 12
FWCI: 10.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (P01 ES11269 and R01 ES015359)
U.S. Environmental Protection Agency through the Science to Achieve Results (STAR) (R829388, R833292)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, IL-1β, IL-4, immune dysregulation, ASD severity, biomarkers, nonverbal cognitive ability, developmental delay, chemokines, brain development
MeSH terms: Autism Spectrum Disorder, Child, Preschool, Female, Humans, Male, Severity of Illness Index, Biomarkers, Interleukin-4, Case-Control Studies, Cytokines, Interleukin-1beta

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Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder

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