It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group

Posttraumatic Stress Disorder in the National Comorbidity Survey

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Clinician-administered PTSD scale: A review of the first ten years of research

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Biological studies of post-traumatic stress disorder

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Post-Traumatic Stress Disorder in the General Population

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Sequenced treatment alternatives to relieve depression (STAR*D): Rationale and design

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Medication Augmentation after the Failure of SSRIs for Depression

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Traumatic events and post‐traumatic stress disorder in the community: prevalence,risk factors and comorbidity

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Prevalence of Mental Health Problems and Functional Impairment Among Active Component and National Guard Soldiers 3 and 12 Months Following Combat in Iraq

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Efficacy and Safety of Sertraline Treatment of Posttraumatic Stress Disorder

Brady, K. T., Pearlstein, T. B., Asnis, G. M., Baker, D. G., ROTHBAUM, B. O., Sikes, C. R., & Farfel, G. M. (2000) · JAMA · doi:10.1001/jama.283.14.1837 · Cited by 707

What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression

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Quetiapine Augmentation of Cognitive Processing Therapy in Veterans with Posttraumatic Stress Disorder. Design and Methodology of a Pilot StudyPreprint

Baig, M. R., Wilson, J. L., Beck, R. D., Lemmer, J. A., Meraj, A., Hernandez, A., Meyer, E. C., Mintz, J., Peterson, A. L., & Roache, J. D. (2021) · Research Square · doi:10.21203/rs.3.rs-812267/v1 · Cited by 2

Large-Scale Functional Hyperconnectivity Patterns Characterizing Trauma-Related Dissociation: A rs-fMRI Study of PTSD and its Dissociative SubtypePreprint

Shaw, S. B., Terpou, B. A., Densmore, M., Théberge, J., Frewen, P., McKinnon, M. C., & Lanius, R. A. (2022) · doi:10.31234/osf.io/b6kdm · Cited by 2

Profiling of research domain criteria-based behaviors following single prolonged stress in male C57BL/6J mice

O’Hara, K., King, S. M., Penrod, R. D., Rinker, J. A., & Mulholland, P. J. (2025) · Stress · doi:10.1080/10253890.2025.2538466 · Cited by 1

Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1

Bonilla, M. I., Lee, H.-L., Foster, S., Kim, I.-J., & Rudenko, A. (2025) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2025.100591 · Cited by 1

Facing trauma under the influence of psychedelics: A phenomenological study with Nova rave survivors

Simon, G., Gal-Birman, M., Tadmor, N., & Halperin, D. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251372508 · Cited by 1

Contributions of the default mode and central executive networks during posterior cingulate cortex-targeted fMRI neurofeedback in PTSD

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Efficacy and risks of psychedelics in the treatment of posttraumatic stress disorder: A systematic review

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Anesthetics as emerging therapeutics for post-traumatic stress disorder (PTSD): bridging bench and bedside

Mei, X., Wu, H., Yuan, T., Samsom, J., Ying, S., Liu, X., Xu, T., Liu, F., & Shen, Y. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03538-y · Cited by 1

Hypothesis on PTSD Pathophysiology: Role of CRH, Noradrenaline, and Glucocorticoid Receptors in an Amygdala-Centered Closed-Loop System

Demori, I., & Burlando, B. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146384 · Cited by 1

Quetiapine augmentation of cognitive processing therapy in veterans with posttraumatic stress disorder. Design and methodology of a pilot study

Mental Health, S. T. V. H. S., & Baig, M. R. (2022) · Journal of Clinical Images and Medical Case Reports · doi:10.52768/2766-7820/2130 · Cited by 1

Safety of Glecaprevir/Pibrentasvir for hepatitis C in patients with posttraumatic stress disorder: A post-marketing surveillance study

Shiner, B. R., Park, J. A., Rozema, L. R., Hoyt, J. E., Watts, B. V., & Gradus, J. L. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.06.012 · Cited by 1

How to design the biofeedback training for the rehabilitation of PTSD patients?

Bazanova, O. M., Zakharov, A. V., Larkova, I., Maryanovskaya, T., Melnikov, А. А., Александровна, Е. С., Nikolenko, E. D., & Shirolapov, I. V. (2023) · IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB) · doi:10.1109/csgb60362.2023.10329818 · Cited by 1

Trends in waking salivary alpha-amylase levels following healing lucid dreams

Yount, G. L., Taddeo, S., Stumbrys, T., Kriegsman, M., & Wahbeh, H. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1347499 · Cited by 1

Development of a Practice Tool for Primary Care Providers: Medication Management of Posttraumatic Stress Disorder in Veterans with Mild Traumatic Brain Injury

Baig, M. R., Meraj, A., & Tapia, R. N. (2020) · Psychiatric Quarterly · doi:10.1007/s11126-020-09767-w · Cited by 1

Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?

Krystal, J. H., Davis, L. L., Neylan, T. C., Raskind, M. A., Schnurr, P. P., Stein, M. B., Vessicchio, J. C., Shiner, B. R., Gleason, T., & Huang, G. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.031 · Cited by 1

Salience Network Disruption in US Army Soldiers with PTSDPreprint

Abdallah, C. G., Averill, C. L., Ramage, A. E., Averill, L. A., Goktas, S., Krystal, J. H., Roache, J. D., Resick, P. A., Young‐McCaughan, S., Peterson, A. L., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/496505 · Cited by 1

Pharmacological Inhibition of BTK reduces neuroinflammation and stress induced anxiety in vivoPreprint

Ghosh, S., Mohammed, Z., & Singh, I. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.11.426241 · Cited by 1

Psychedelic-Assisted Psychotherapy: A Literature Review

Welch, M. V. (2022) · doi:10.46569/20.500.12680/rv043153s · Cited by 1

Individual variability and sexually dimorphic fear memory-related effects of anxiety on fear extinction in inbred mouse modelPreprint

Rudenko, A. (2023) · doi:10.31234/osf.io/b84zx · Cited by 1

The impact of doxycycline on human contextual fear memoryPreprint

Wehrli, J. M., Xia, Y., Abivardi, A., Kleim, B., & Bach, D. R. (2024) · doi:10.31234/osf.io/m5cyv · Cited by 1

The PTSD Psychopharmacology Working Group: Two Suggestions

Jindal, R. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.004

Exposição prolongada pós-evocação de memória no paciente traumatizado

Vermes, J. S. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.47.2020.tde-18022020-155143

Design of the National Adaptive Trial for PTSD-related Insomnia (NAP Study), VA Cooperative Study Program (CSP) #2016

Krystal, J. H., Chow, B. K., Vessicchio, J. C., Henrie, A. M., Neylan, T. C., Krystal, A. D., Marx, B. P., Xu, K., Jindal, R. D., Davis, L. L., et al. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106540

Sexually dimorphic interplay between anxiety-related phenotype and fear memory extinctionPreprint

Bonilla, M. I., Lee, H.-L., Kim, I.-J., & Rudenko, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.17.460842

Psychotropic medication use in the Armed Forces: prescription patterns and treatment after trauma

Janssen, D. G. A. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/923

Development and validation of a post-traumatic stress disorder model in zebrafish

Loots, H. (2021) · Boloka Institutional Repository (North-west University)

Effects of Intranasal (S)-Ketamine on Veterans With Co-Morbid Treatment-Resistant Depression and PTSDPreprint

Artin, H., Bentley, S., Mehaffey, E., Liu, F. X., Sojourner, K., Bismark, A. W., PRINTZ, D. J., Lee, E., Martis, B., Peralta, S. D., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3928508

The Role(s) of Psychopharmacology in the Treatment of PTSD

Baig, M. R., & Roache, J. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00150-x · Cited by 1

Modulating the Endocannabinoid System as a Therapeutic Approach for Posttraumatic Stress Disorder: Could Translational Research on Fear and Extinction Learning Predict Clinical Benefit?

Schmidt, M. E. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.10.014

Quetiapine augmentation of cognitive processing therapy in veterans with posttraumatic stress disorder. Design and methodology of a pilot study (Preprint)Preprint

Baig, M. R. (2022) · doi:10.2196/preprints.36604

Genetic and Social-Environmental Influences on Posttraumatic Stress Disorder

Lawn, R. B. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.12.010

Exploración de las alteraciones de la conectividad funcional en esquizofrenia

Lorenzana, A. R. (2021) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/52880

Adverse effects

Kumar, V. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90903-7.00009-0

Anti-Depression a Systematic Review of Analytical methods in PharmaceuticalsPreprint

Perumal, D., Krishnan, M., & K.S, L. (2022) · doi:10.22541/au.165658161.19930674/v1

Adherence with Treatment for Sleep Apnea in Patients with Comorbid Post-traumatic Stress Disorder

Jindal, R. D., & Garg, K. (2022) · Springer eBooks · doi:10.1007/978-3-030-93146-9_20

Trauma and resilience

Beyer, C., & Stein, D. J. (2022) · Oxford University Press eBooks · doi:10.1093/med/9780198861478.003.0018

Impact of Multi-site Clinical Trial Results on Clinical Practice: Use of Risperidone to Treat PTSD Nationally in the Veterans Health Administration

Rosenheck, R. A., Kurtz, S. G., Anand, S. T., Hau, C., Smedberg, D. L., Sicilia, R., Pontzer, J. F., & Ferguson, R. E. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115071

Brain-based transcriptomic architecture associated with high and low efficacy of fear extinction learningPreprint

Rudenko, A. (2023) · doi:10.31234/osf.io/qrmxp

Avaliação da participação do sistema endocanabinoide na memória de extinção do medo condicionado em camundongos

Werworn, L. F. M. (2022) · doi:10.11606/d.60.2022.tde-25082023-094452

Pimavanserin 34 mg at Bedtime for the Treatment of Insomnia in 6 Veterans With Posttraumatic Stress Disorder

Jones, M. B., Agrawal, R., Sharafkhaneh, A., Bhatti, G. S., Li, R., Marsh, L., & Jorge, R. E. (2023) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.23br14992

Is Ketamine Infusion an Effective Treatment for Post-Traumatic Stress Disorder? A Meta-AnalysisPreprint

Mowdawalla, C., Pradhan, B., Mitrev, L. V., Hunter, K., Saracco, B., Kim, H. W., & van Helmond, N. (2023) · Research Square · doi:10.21203/rs.3.rs-3559310/v1

Psychotraumatismes et addictions

Leroy, A., Cottencin, O., & Vaïva, G. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77934-3.00010-x

Enhancing massed prolonged exposure with cannabidiol to improve posttraumatic stress disorder: Design and methodology of a pilot randomized clinical trial

Straud, C. L., Roache, J. D., Ginsburg, B. C., Baig, M. R., King, V. L., Barron, S., Blount, T. H., Young‐McCaughan, S., & Peterson, A. L. (2024) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2024.101270

The Effects of Full Spectrum Hemp Oil on Extinction of Stress-Enhanced Fear Learning: A Rat Model of PTSD

Chanel, T., Vigil, J. M., & Pentkowski, N. S. (2024) · Current Research in Complementary & Alternative Medicine · doi:10.29011/2577-2201.100244

Efeitos comportamentais e moleculares do butirato de sódio no córtex pré-frontal de camundongos expostos a um modelo de transtorno de estresse pós-traumático

Coelho, A. A. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2024.tde-25072024-105142

Effects of phosphodiesterase 4 inhibition after a short memory retrieval of contextual fear conditioning in rats

Sohn, J. M. B. (2024) · doi:10.26481/dis.20240606js

The neural circuitry of PTSD—An RDOC approach

Allam, A. K., Larkin, M. B., Viswanathan, A., Sheth, S. A., & Banks, G. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95437-2.00003-3 · Cited by 1

Design and methodology of a randomized clinical trial of quetiapine to reduce central nervous system polypharmacy in veterans with postconcussive syndrome symptoms

Baig, M. R., Villarreal, G., Aviles, L., Meraj, A., Davis, B., Meyer, E. C., Straud, C. L., Young‐McCaughan, S., Peterson, A. L., & Roache, J. D. (2024) · Contemporary Clinical Trials · doi:10.1016/j.cct.2024.107741

Grundlagen der Diagnostik und Therapie

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Temporal Immune Effects of Oral Ketamine on PTSD: Transcriptomic Evidence of Short-Term Inflammation Suppression and Long-Term Immune RemodellingPreprint

Wellington, N. J., Quigley, B. L., Bouças, A. P., Dutton, M., Can, A., Lagopoulos, J., & Kuballa, A. (2025) · medRxiv · doi:10.1101/2025.05.26.25328370

Knowledge, mechanisms, and intervention of the polytrauma clinical triad in military pain medicine

Liu, Q., Qiu, P., Ma, T., Zhao, Y., Fu, S., Gao, M., Feng, Z., & Feng, L. (2025) · The Korean journal of pain · doi:10.3344/kjp.24425 · Cited by 2

Fixed-Dose Brexpiprazole and Sertraline Combination Therapy for the Treatment of Posttraumatic Stress Disorder

Davis, L. L., Behl, S., Lee, D. J., Zeng, H., Skubiak, T., Weaver, S., Hefting, N., Larsen, K. G., & Hobart, M. (2025) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000002076

DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation

Huang, X., Chen, D., Wang, Y., Zhang, Y., Ntim, M., Ge, Y., & Wang, B. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i11.110581

Targeting PTSD with ultramicronized palmitoylethanolamide: Results from a randomized trial integrating pharmacotherapy and cognitive behavioral therapy

Steardo, L., D'Angelo, M., Stefano, V. D., Monaco, F., Fornaro, M., & Steardo, L. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.10.071 · Cited by 1

Concomitant Psychotropic Medication Is Associated with Reduced Outcomes of Trauma-Focused Psychotherapy for Post-Traumatic Stress Disorder

Steenen, S. A., van Westrhenen, R., Steenen, C. C., Klausch, L. T., & de Jongh, A. (2025) · Psychotherapy and Psychosomatics · doi:10.1159/000549259

Temporal immune effects of Oral ketamine on PTSD: Transcriptomic evidence of short-term inflammation suppression and sustained immune Remodelling

Wellington, N. J., Quigley, B. L., Bouças, A. P., Dutton, M., Can, A., Lagopoulos, J., & Kuballa, A. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120791

Additional file 1 of Bruton’s tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress

Ghosh, S., Mohammed, Z., & Singh, I. (2021) · Figshare · doi:10.6084/m9.figshare.17162831

Rodent models of posttraumatic stress disorder

Pinna, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00015-5

Far Out: Psychedelics are Becoming a Current Treatment Option in Psychiatry

Borgogna, N. C., & Aita, S. L. (2025) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-025-00374-9

A Systematic Review of the efficacy, safety, and Tolerability of Psychedelics in the Treatment of post-traumatic Stress Disorder

Wongpaiboon, M., Shelton, J. L., Rendon, E. D., & Vail, M. (2025) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-025-00373-w

Circuits neuronaux sous-tendant la régulation émotionnelle par le système ocytocinergique

Goyon, S. (2018) · theses.fr (ABES) · doi:10.70675/c8c9bec0z7b79z4826z862az93b128e1ada6

Precision phenotyping of elevated arousal in posttraumatic stress disorder: implications for personalized GABAergic pharmacotherapy

Vasquez, V. R., & Howlett, J. R. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1764293

Sexually dimorphic effects of single prolonged stress on conditioned suppression behavior in Long Evans rats with no detection of altered mRNA expression of VGLUT1, GAD1, and Arc in the ventral hippocampus

Pitcairn, S. R., Tapp, A. E., Drenan, R. M., & Weiner, J. L. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1771722

Stellate ganglion block for posttraumatic stress disorder in Canadian Armed Forces Veterans and Royal Canadian Mounted Police: A case series

Gomez, R., Geck, C., James, D., Cassidy, C., Taylor, C. C., & Shlik, J. (2026) · Journal of Military Veteran and Family Health · doi:10.3138/jmvfh-2026-0003

The role of exercise in post-traumatic stress disorder: clinical evidence, sleep, cognition, and psychotherapy augmentation

Li, Y., & 李书义 (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1889239

MDMA-Assisted Therapy May Decrease PTSD Symptoms, Dissociation, Depression, and Functional Disability: A Systematic Review and Meta-Analysis

Green, W., Raut, S. B., James, F. L. J., Benedek, D. M., Ursano, R. J., Capaldi, V. F., & Johnson, L. R. (2026) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000478

The Pharmacotherapeutic Alliance: An Evidence-Based Intervention for Enhancing Psychiatric Outcomes

Mintz, D. L., Kennedy, K. P., Pine, J. H., Sumner, C. R., Alexander, J. L., Gross, L. S., Parikh, T., Garakani, A., & Baron, D. A. (2026) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20260142

In Vivo Characterization of Fatty Acid Amide Hydrolase in Posttraumatic Stress Disorder: A [11C]CURB Positron Emission Tomography Study

Gaudette, E. V., Green, D. G. J., Watling, S. E., Dheda, S. S., Lora, S., Zilberman, M., Hill, M. N., Tyndale, R. F., Richardson, J. D., McCluskey, T., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.09.008

Benzodiazepine prescribing in chronic military-related PTSD: real-world patterns and correlates in specialized care

Collins, E., Liu, J. J. W., Bilodeau, M., Burhan, A. M., Enns, M. W., Lavoie, V., Ein, N., Nazarov, A., Auger, É., Balderson, K., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1931305

The PTSD Psychopharmacology Working Group: Two Suggestions

Jindal, R. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.004

Response to the Consensus Statement of the PTSD Psychopharmacology Working Group

Feduccia, A. A., Mithoefer, M. C., Jerome, L., Holland, J. A., Emerson, A., & Doblin, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.023 · Cited by 3

A Collaborative Psychopharmacology Research Agenda for Posttraumatic Stress Disorder

Gordon, J. A., Borja, S. E., & Tuma, F. K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.019 · Cited by 5

It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?

Lipov, E., Tukan, A., & Candido, K. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.026 · Cited by 4

Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?

Krystal, J. H., Davis, L. L., Neylan, T. C., Raskind, M. A., Schnurr, P. P., Stein, M. B., Vessicchio, J. C., Shiner, B. R., Gleason, T., & Huang, G. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.031 · Cited by 1