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It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group
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“Increasing evidence suggests that these circuitry treatment effects are mediated by changes in synaptic plasticity in key areas of the circuitry (Krystal et al., 2017;Luchkina & Bolshakov, 2018;Mahan & Ressler, 2012;Mansson et al., 2016;Mansson et al., 2017).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Krystal et al., 2017
In the citing paper
“and, indeed, patients with an anxiety disorder display abnormal levels of glutamate and glutamate receptors (Krystal et al., 2017).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Krystal et al., 2017
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“Stress that is considered a risk factor in the development of anxiety disorders alters levels of glutamate in rodents, and, indeed, patients with an anxiety disorder display abnormal levels of glutamate and glutamate receptors (Krystal et al., 2017).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Krystal et al., 2017
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Self-citation
Research works printed but not linked: 2
- Shiner, 2016, Preliminary analysis of 1-year psychotropic medication receipt among VA patients with new episodes of PTSD care, 2004-2013, Ongoing VA-Funded Research
- 2013, A randomized, double-blind, placebo-controlled parallel-group, fixed-dose study evaluating the efficacy and safety of the neurokinin-1 receptor antagonist orvepitant (GW823296) in post traumatic stress disorder (PTSD), Protocol summary
Cited by
Sorted by citations
Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Ressler, K. J., Berretta, S., Bolshakov, V. Y., Rosso, I. M., Meloni, E. G., Rauch, S. L., & Carlezon, W. A. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00635-8 · Cited by 572
Mithoefer, M. C., Mithoefer, A. T., Feduccia, A. A., Jerome, L., Wagner, M., Wymer, J., Holland, J., Hamilton, S., Yazar-Klosinski, B., Emerson, A., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30135-4 · Cited by 439
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Alexandra Kredlow, M., Fenster, R. J., Laurent, E. S., Ressler, K. J., & Phelps, E. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01155-7 · Cited by 346
“In contrast to the promise of current scientific approaches, in the clinic PTSD remains very difficult to treat [15, 16].”
ResultReviewing the Potential of Psychedelics for the Treatment of PTSD
Krediet, E., Bostoen, T., Breeksema, J., van Schagen, A., Passie, T., & Vermetten, E. (2020) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa018 · Cited by 260
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Metadata
- Authors
- Krystal, J. H., Davis, L. L., Neylan, T. C., A. Raskind, M., Schnurr, P. P., Stein, M. B., Vessicchio, J., Shiner, B., Gleason, T. D., & Huang, G. D.
- Affiliations
- Yale University (US)
- University of Alabama (US)
- San Francisco VA Medical Center (US)
- National Center for Post Traumatic Stress Disorder (US)
- University of California San Diego (US)
- VA Connecticut Healthcare System (US)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Krystal, John H.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 82
- Issue
- 7
- Pages
- e51-e59
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2598895258
- Cited by
- 265
- References
- 61
- Citations by year
- 2026: 15 · 2025: 33 · 2024: 26 · 2023: 31 · 2022: 30 · 2021: 41 · 2020: 30 · 2019: 26 · 2018: 26 · 2017: 6
- FWCI
- 28.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biological Psychiatry (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- VA Office of Research and Development Clinical Science Research & Development Service and Cooperative Studies Program
- National Institutes of Health
- Pfizer
- AstraZeneca
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Mental Health
- Department of Veterans Affairs
- Department of Defense
- Lilly Pharmaceuticals
- VA Health Services Research and Development Career Development Award
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Keywords
- post-traumatic stress disorder, pharmacotherapy, psychopharmacology, treatment gap, veterans, military personnel, Department of Veterans Affairs, Department of Defense
- MeSH terms
- Animals, Clinical Trials as Topic, Humans, Psychopharmacology, Psychotropic Drugs, Stress Disorders, Post-Traumatic
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