The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors
Open accessAbstract
Background Maternal cortisol during pregnancy has the potential to influence rapidly developing fetal brain systems that are commonly altered in neurodevelopmental and psychiatric disorders. Research examining maternal cortisol concentrations across pregnancy and offspring neurodevelopment proximal to birth is needed to advance understanding in this area and lead to insight into the etiology of these disorders.Methods Participants were 70 adult women recruited during early pregnancy and their infants born after 34 weeks gestation. Maternal cortisol concentrations were assessed serially over 4 days in early, mid, and late gestation. Resting state functional connectivity magnetic resonance imaging of the neonatal amygdala was examined. Mothers reported on children's internalizing behavior problems at 24 months of age.Results Maternal cortisol concentrations during pregnancy were significantly associated with neonatal amygdala connectivity in a sex-specific manner. Elevated maternal cortisol was associated with stronger amygdala connectivity to brain regions involved in sensory processing and integration, as well as the default mode network in girls, and with weaker connectivity to these brain regions in boys. Elevated maternal cortisol was associated with higher internalizing symptoms in girls only, and this association was mediated by stronger neonatal amygdala connectivity.Conclusions Normative variation in maternal cortisol during pregnancy is associated with the coordinated functioning of the amygdala soon after birth in a sex-specific manner. The identified pathway from maternal cortisol to higher internalizing symptoms in girls via alterations in neonatal amygdala connectivity may be relevant for the etiology of sex differences in internalizing psychiatric disorders, which are more prevalent in women.
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“In females, higher cortisol levels are correlated with greater amygdala connectivity to diverse networks (e.g., default mode network and emotion regulation); the reverse is true in males [117].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [117]
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“One previous study shows that maternal cortisol predicts internalizing score on the Child Behavior Checklist at 2 years of age.”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [117]
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“In girls, this relationship is mediated by increased amygdala connectivity [117].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [117]
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Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
McLean, C. P., Asnaani, A., Litz, B. T., & Hofmann, S. G. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.006 · Cited by 2,519
Functional brain networks develop from a local to distributed organization
Fair, D. A., Cohen, A. L., Power, J. D., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Schlaggar, B. L., & Petersen, S. E. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000381 · Cited by 1,530
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Guo, Y., Liu, J., Peng, Y., & Li, X. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1922174
Kłoska, A., Jakiel, G., Jakóbkiewicz‐Banecka, J., Raczkiewicz, D., Malinowska, M., Włodarczyk, M., Szymańska, J., & Słabuszewska-Jóźwiak, A. (2026) · Research Square · doi:10.21203/rs.3.rs-10975857/v1
Babineau, V., Lee, S., Zhang, Z., Jiang, Z., Werner, E., Ginrich, J., Posner, J. E., Peterson, B. S., & Monk, C. (2026) · Research Square · doi:10.21203/rs.3.rs-10092045/v1
Harvison, M., & Silveira, P. P. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19043-8.00004-9
Early Infant Subcortical Volume is Associated with Maternal Prenatal Depression
Morgan, H. L., Cioffredi, L., Scoppettone, N., Barrows, A. J., Lorenzo, N. E., Zhang, J., Garavan, H., & Potter, A. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100859
Metadata
- Authors
- Graham, A. M., Rasmussen, J. M., Entringer, S., Ben Ward, E., Rudolph, M. D., Gilmore, J. H., Styner, M., Wadhwa, P. D., Fair, D. A., & Buss, C.
- Affiliations
- Oregon Health & Science University (US)
- University of California, Irvine (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Wadhwa, Pathik D.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 85
- Issue
- 2
- Pages
- 172-181
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC6632079
- OpenAlex
- W2859733407
- Cited by
- 203
- References
- 103
- Citations by year
- 2026: 22 · 2025: 16 · 2024: 26 · 2023: 23 · 2022: 24 · 2021: 43 · 2020: 30 · 2019: 15
- FWCI
- 23.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Child Health and Human Development (R01 HD060628)
- National Institute of Mental Health (R01 MH091351)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- maternal cortisol, pregnancy, amygdala functional connectivity, sex differences, internalizing problems, early childhood, default mode network, prenatal stress, brain development
- MeSH terms
- Adult, Amygdala, Child, Preschool, Female, Humans, Hydrocortisone, Infant, Newborn, Internal-External Control, Magnetic Resonance Imaging, Male, Mothers, Neural Pathways, Pregnancy, Saliva, Sex Characteristics, Time Factors, Young Adult, Functional Neuroimaging
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