Cited by 209Maternal Mental Health During Pregnancy and PostpartumStress Responses and CortisolFunctional Brain Connectivity Studies

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Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors

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Graham, Alice M., Rasmussen, Jerod M., Entringer, Sonja, Ben Ward, Elizabeth, Rudolph, Marc D., Gilmore, John H., Styner, Martin, Wadhwa, Pathik D., Fair, Damien A., Buss, Claudia·2019·Biological Psychiatry

DOI 10.1016/j.biopsych.2018.06.023PMC PMC6632079

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Abstract

Background Maternal cortisol during pregnancy has the potential to influence rapidly developing fetal brain systems that are commonly altered in neurodevelopmental and psychiatric disorders. Research examining maternal cortisol concentrations across pregnancy and offspring neurodevelopment proximal to birth is needed to advance understanding in this area and lead to insight into the etiology of these disorders.Methods Participants were 70 adult women recruited during early pregnancy and their infants born after 34 weeks gestation. Maternal cortisol concentrations were assessed serially over 4 days in early, mid, and late gestation. Resting state functional connectivity magnetic resonance imaging of the neonatal amygdala was examined. Mothers reported on children's internalizing behavior problems at 24 months of age.Results Maternal cortisol concentrations during pregnancy were significantly associated with neonatal amygdala connectivity in a sex-specific manner. Elevated maternal cortisol was associated with stronger amygdala connectivity to brain regions involved in sensory processing and integration, as well as the default mode network in girls, and with weaker connectivity to these brain regions in boys. Elevated maternal cortisol was associated with higher internalizing symptoms in girls only, and this association was mediated by stronger neonatal amygdala connectivity.Conclusions Normative variation in maternal cortisol during pregnancy is associated with the coordinated functioning of the amygdala soon after birth in a sex-specific manner. The identified pathway from maternal cortisol to higher internalizing symptoms in girls via alterations in neonatal amygdala connectivity may be relevant for the etiology of sex differences in internalizing psychiatric disorders, which are more prevalent in women.

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Authors: Graham, A. M., Rasmussen, J. M., Entringer, S., Ben Ward, E., Rudolph, M. D., Gilmore, J. H., Styner, M., Wadhwa, P. D., Fair, D. A., & Buss, C.
Affiliations: Oregon Health & Science University (US)
University of California, Irvine (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Wadhwa, Pathik D.
ORCID: Graham, Alice M.
Rasmussen, Jerod M.
Entringer, Sonja
Rudolph, Marc D.
Gilmore, John H.
Styner, Martin
Wadhwa, Pathik D.
Fair, Damien A.
Buss, Claudia
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2019-01
Volume: 85
Issue: 2
Pages: 172-181
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2018.06.023
PMC: PMC6632079
OpenAlex: W2859733407
Cited by: 203
References: 103
Citations by year: 2026: 22 · 2025: 16 · 2024: 26 · 2023: 23 · 2022: 24 · 2021: 43 · 2020: 30 · 2019: 15
FWCI: 23.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Child Health and Human Development (R01 HD060628)
National Institute of Mental Health (R01 MH091351)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: maternal cortisol, pregnancy, amygdala functional connectivity, sex differences, internalizing problems, early childhood, default mode network, prenatal stress, brain development
MeSH terms: Adult, Amygdala, Child, Preschool, Female, Humans, Hydrocortisone, Infant, Newborn, Internal-External Control, Magnetic Resonance Imaging, Male, Mothers, Neural Pathways, Pregnancy, Saliva, Sex Characteristics, Time Factors, Young Adult, Functional Neuroimaging

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Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors

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