The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats
Open accessAbstract
Background We recently reported that operant social choice-induced voluntary abstinence prevents incubation of methamphetamine craving. Here, we determined whether social choice-induced voluntary abstinence would prevent incubation of heroin craving. We also introduce a fully automatic social reward self-administration model that eliminates the intense workload and rat-human interaction of the original semiautomatic model.Methods In experiment 1, we trained male and female rats for social self-administration (6 days) and then for heroin self-administration (12 days). Next, we assessed relapse to heroin seeking after 1 and 15 abstinence days. Between tests, the rats underwent either forced or social choice-induced abstinence. In experiment 2, we developed a fully automatic social self-administration procedure by introducing a screen between the self-administration chamber and the social-peer chamber; the screen allows physical contact but prevents rats from crossing chambers. Next, we compared incubation of craving in rats with a history of standard (no-screen) or automatic (screen) social self-administration and social choice-induced abstinence.Results The time-dependent increase in heroin seeking after cessation of drug self-administration (incubation of craving) was lower after social choice-induced abstinence than after forced abstinence. There were no differences in social self-administration, social choice-induced abstinence, and incubation of craving in rats trained in the standard semiautomatic procedure versus the novel fully automatic procedure.Conclusions Our study demonstrates the protective effect of rewarding social interaction on heroin self-administration and incubation of heroin craving and introduces a fully automatic social self-administration and choice procedure to investigate the role of volitional social interaction in drug addiction and other psychiatric disorders.
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“the opportunity to socialize reduces drug seeking for both methamphetamine and heroin [145,146].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [146]
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The reinstatement model of drug relapse: history, methodology and major findings
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Self-citationThe Neuroscience of Natural Rewards: Relevance to Addictive Drugs
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Incubation of cocaine craving after withdrawal
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Self-citationNeurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880
Self-citationPeciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671
Neurobiology of the incubation of drug craving
Pickens, C. L., Airavaara, M., Theberge, F. R. M., Fanous, S., Hope, B. T., & Shaham, Y. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.001 · Cited by 657
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Improving translation of animal models of addiction and relapse by reverse translation
Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H., & Shaham, Y. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0378-z · Cited by 212
Self-citationSex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review
Nicolas, C., Zlebnik, N. E., Farokhnia, M., Leggio, L., Ikemoto, S., & Shaham, Y. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000367 · Cited by 151
Self-citationAnimal Models of Drug Relapse and Craving after Voluntary Abstinence: A Review
Fredriksson, I., Vènniro, M., Reiner, D. J., Chow, J. J., Bossert, J. M., & Shaham, Y. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000191 · Cited by 104
Self-citationAn operant social self-administration and choice model in rats
Vènniro, M., & Shaham, Y. (2020) · Nature Protocols · doi:10.1038/s41596-020-0296-6 · Cited by 94
Self-citationVènniro, M., Panlilio, L. V., Epstein, D. H., & Shaham, Y. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01148-6 · Cited by 92
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Metadata
- Authors
- Venniro, M., Russell, T. I., Zhang, M., & Shaham, Y.
- Affiliations
- National Institutes of Health (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 86
- Issue
- 11
- Pages
- 848-856
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC8383184
- OpenAlex
- W2947439413
- Cited by
- 127
- References
- 75
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 16 · 2023: 13 · 2022: 28 · 2021: 25 · 2020: 21 · 2019: 2
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse
- National Institutes of Health
- National Alliance for Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- heroin craving, incubation of craving, social reward, heroin self-administration, relapse, sex differences, drug addiction, social interaction
- MeSH terms
- Animals, Behavior, Animal, Choice Behavior, Heroin, Extinction, Psychological, Feeding Behavior, Female, Male, Methamphetamine, Reward, Self Administration, Social Behavior, Rats, Sprague-Dawley, Rats, Drug-Seeking Behavior, Craving
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