Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?
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μ-Opioid systems in the medial shell of the nucleus accumbens contribute to hedonic impact (“liking”) for sweetness, food, and drug rewards. But does the entire medial shell generate reward hedonic impact? Or is there a specific localized site for opioid enhancement of hedonic “liking” in the medial shell? And how does enhanced taste hedonic impact relate to opioid-stimulated increases in food intake? Here, we used a functional mapping procedure based on microinjection Fos plumes to localize opioid substrates in the medial shell of the nucleus accumbens that cause enhanced “liking” reactions to sweet pleasure and that stimulate food intake. We mapped changes in affective orofacial reactions of “liking”/“disliking” elicited by sucrose or quinine tastes after d-Ala 2-N-Me-Phe 4-Glycol 5-enkephalin (DAMGO) microinjections in rats and compared hedonic increases to food intake stimulated at the same sites. Our maps indicate that opioid-induced increases in sucrose hedonic impact are generated by a localized cubic millimeter site in a rostrodorsal region of the medial shell. In contrast, all regions of the medial shell generated DAMGO-induced robust increases in eating behavior and food intake. Thus, our results identify a locus for opioid amplification of hedonic impact and reveal a distinction between opioid mechanisms of food intake and hedonic impact. Opioid circuits for stimulating food intake are widely distributed, whereas hedonic “liking” circuits are more tightly localized in the rostromedial shell of the nucleus accumbens.
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Berridge and colleagues demonstrated narrowly circumscribed, μ-opioid receptor-mediated pleasure ("liking") hotspots in the nucleus accumbens shell and ventral pallidum.
“Using this method, Berridge and colleagues ([12](#B12), [122](#B122)) have demonstrated narrowly circumscribed, μ-opioid receptor-mediated pleasure (“liking”) hotspots in the nucleus accumbens shell and ventral pallidum.”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [122]
Pleasurable or rewarding experiences comprise an anticipatory 'wanting' component and an 'in-the-moment enjoyment' (liking) component.
“Current evidence suggests that, cognitively, pleasurable or rewarding experiences, in general, comprise a “looking forward to” anticipatory component, which is cognitively driven (i.e., “wanting”) (23, 24), and an “in-the-moment enjoyment” (i.e., “liking”) component (25, 26).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [26]
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Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats
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κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance
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“D2-like receptors are expressed on neurons that contain enkephalin, an endogenous ligand for -opioid receptors that mediate motivation and positive hedonics (Bozarth and Wise, 1981; Gerfen and Young, 1988; Pecina and Berridge, 2005).”
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- Authors
- Peciña, S., & Berridge, K. C.
- Affiliations
- University of Michigan (US)
- ORCID
- Berridge, Kent C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-12-14
- Volume
- 25
- Issue
- 50
- Pages
- 11777-11786
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6726018
- OpenAlex
- W2140830026
- Cited by
- 671
- References
- 56
- Citations by year
- 2026: 19 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 19 · 2021: 53 · 2020: 78 · 2019: 33 · 2018: 37 · 2017: 27 · 2016: 38 · 2015: 35 · 2014: 32 · 2013: 43 · 2012: 50
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH-63649, R01MH063649)
- National Institute on Drug Abuse (DA015188, R01DA015188)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- mu-opioid system, nucleus accumbens shell, hedonic liking, sweet taste, sucrose, DAMGO, dietary intake, Fos expression, reward
- MeSH terms
- Animals, Eating, Food Preferences, Male, Microinjections, Nucleus Accumbens, Reward, Sucrose, Sweetening Agents, Rats, Sprague-Dawley, Receptors, Opioid, mu, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Rats
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