Evidence for Addiction-like Behavior in the Rat
Abstract
Although the voluntary intake of drugs of abuse is a behavior largely preserved throughout phylogeny, it is currently unclear whether pathological drug use (“addiction”) can be observed in species other than humans. Here, we report that behaviors that resemble three of the essential diagnostic criteria for addiction appear over time in rats trained to self-administer cocaine. As in humans, this addiction-like behavior is present only in a small proportion of subjects using cocaine and is highly predictive of relapse after withdrawal. These findings provide a new basis for developing a true understanding and treatment of addiction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Paradigms have been developed to model compulsive drug-seeking despite negative consequences by pairing drug delivery with aversive stimuli.
“More recently, paradigms have been developed to model compulsive drug-seeking despite negative consequences, which pair drug delivery with various aversive stimuli such as electric shock (Deroche-Gamonet et al 2004), bitter taste (Wolffgramm and Heyne 1995), or fear-conditioned cues (Vanderschuren and Everitt 2004).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Deroche-Gamonet et al 2004
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535 · see citing works
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Richardson, N. R., & Roberts, D. C. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00153-0 · Cited by 1,357 · see citing works
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355 · see citing works
Self-citationAnthony, J. C., Warner, L. A., & Kessler, R. C. (1994) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.2.3.244 · Cited by 1,341 · see citing works
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,315 · see citing works
Addiction and the brain: The neurobiology of compulsion and its persistence
Hyman, S. E., & Malenka, R. C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094560 · Cited by 1,297 · see citing works
Impulsive choice induced in rats by lesions of the nucleus accumbens core
Cardinal, R. N., Pennicott, D. R., Lakmali, C., Sugathapala, Robbins, T. W., & Everitt, B. J. (2001) · Science · doi:10.1126/science.1060818 · Cited by 923 · see citing works
Wise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881 · see citing works
Stress-induced relapse to heroin and cocaine seeking in rats: a review
Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 703 · see citing works
Psychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700 · see citing works
Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats
Weeks, J. R. (1962) · Science · doi:10.1126/science.138.3537.143 · Cited by 658 · see citing works
Behavioral Analysis of Drug Dependence
Goldberg, S. R., & Stolerman, I. P. (1986) · Medical Entomology and Zoology · Cited by 549 · see citing works
Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
Ito, R., Robbins, T. W., & Everitt, B. J. (2004) · Nature Neuroscience · doi:10.1038/nn1217 · Cited by 501 · see citing works
Self Administration of and Behavioral Dependence on Drugs
Schuster, C. R., & Thompson, T. I. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002411 · Cited by 492 · see citing works
Piazza, P. V., Deroche-Gamonent, V., Rougé‐Pont, F., & Moal, M. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04226.2000 · Cited by 353 · see citing works
Self-citationSelf-administration of d-amphetamine by rats
Pickens, R. W., & Harris, W. C. (1968) · Psychopharmacology · doi:10.1007/bf00401545 · Cited by 296 · see citing works
Spanagel, R., Montkowski, A., Allingham, K., Shoaib, M., Holsboer, F., & Landgraf, R. (1995) · Psychopharmacology · doi:10.1007/bf02246268 · Cited by 219 · see citing works
Individual differences in the reinforcing and subjective effects of amphetamine and diazepam
de Wit, H., UHLENHUTH, E. H., & Johanson, C. E. (1986) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(86)90068-2 · Cited by 212 · see citing works
Crowley, T. J., Mikulich, S. K., Macdonald, M. J., Young, S. E., & Zerbe, G. O. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00016-7 · Cited by 167 · see citing works
Early Reactions to Cannabis Predict Later Dependence
Fergusson, D. M., Horwood, L. J., Lynskey, M. T., & Madden, P. A. F. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.10.1033 · Cited by 166 · see citing works
Homberg, J. R., Akker, M. V. D., Raasø, H. S., Wardeh, G., Binnekade, R., Schoffelmeer, A. N. M., & Vries, T. J. D. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01976.x · Cited by 106 · see citing works
Morphine: Conditioned Increases in Self-Administration in Rhesus Monkeys
Goldberg, S. R., Woods, J. H., & Schuster, C. R. (1969) · Science · doi:10.1126/science.166.3910.1306 · Cited by 92 · see citing works
Pharmacogenomics of Alcohol Response and Addiction
Enoch, M. (2003) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200303040-00001 · Cited by 87 · see citing works
Abramson, C. I., Stone, S. M., Ortez, R. A., Luccardi, A., Vann, K. L., Hanig, K. D., & Rice, J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200008000-00004 · Cited by 84 · see citing works
Relapse Prevention: An Emerging Technology for Promoting Long-Term Drug Abstinence
DeJong, W. (1994) · International Journal of the Addictions · doi:10.3109/10826089409047904 · Cited by 79 · see citing works
Reinforcing effects of methamphetamine in planarians
Kusayama, T., & Watanabe, S. (2000) · Neuroreport · doi:10.1097/00001756-200008030-00033 · Cited by 66 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717 · see citing works
Hasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645 · see citing works
Impulsivity, compulsivity, and top-down cognitive control
Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.020 · Cited by 1,589 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457 · see citing works
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
Drug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225 · see citing works
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105 · see citing works
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013 · see citing works
High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
Belin, D., Mar, A. C., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2008) · Science · doi:10.1126/science.1158136 · Cited by 989 · see citing works
Self-citationAddiction: A Disease of Learning and Memory
Hyman, S. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1414 · Cited by 980 · see citing works
Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0089 · Cited by 974 · see citing works
Self-citationPlasticity of reward neurocircuitry and the ‘dark side’ of drug addiction
Koob, G. F., & Le Moal, M. (2005) · Nature Neuroscience · doi:10.1038/nn1105-1442 · Cited by 963 · see citing works
The role of impulsive behavior in drug abuse
Perry, J. L., & Carroll, M. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1173-0 · Cited by 805 · see citing works
Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748 · see citing works
Belin, D., & Everitt, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.019 · Cited by 697 · see citing works
Self-citationFrom the ventral to the dorsal striatum: devolving views of their roles in drug addiction
Everitt, B. J., & Robbins, T. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.010 · Cited by 675 · see citing works
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
Sanchis‐Segura, C., & Spanagel, R. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00012.x · Cited by 629 · see citing works
Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works
Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking
Chen, B. T., Yau, H.-J., Hatch, C., Kusumoto-Yoshida, I., Cho, S. L., Hopf, F. W., & Bonci, A. (2013) · Nature · doi:10.1038/nature12024 · Cited by 498 · see citing works
Fineberg, N. A., Chamberlain, S. R., Goudriaan, A. E., Stein, D. J., Vanderschuren, L. J. M. J., Gillan, C. M., Shekar, S., Gorwood, P. A. P. M., Voon, V., Morein-Zamir, S., et al. (2014) · CNS Spectrums · doi:10.1017/s1092852913000801 · Cited by 488 · see citing works
Epigenetic mechanisms in cognition
Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works
Addiction as a stress surfeit disorder
Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.024 · Cited by 483 · see citing works
Obesity and the brain: how convincing is the addiction model?
Ziauddeen, H., Farooqi, I. S., & Fletcher, P. C. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3212 · Cited by 462 · see citing works
Involvement of the dorsal striatum in cue-controlled cocaine seeking
Vanderschuren, L. J. M. J., Di Ciano, P., & Everitt, B. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0925-05.2005 · Cited by 393 · see citing works
Addiction is a Reward Deficit and Stress Surfeit Disorder
Koob, G. F. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00072 · Cited by 397 · see citing works
The integrative function of the basal ganglia in instrumental conditioning
Balleine, B. W., Liljeholm, M., & Ostlund, S. B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.034 · Cited by 356 · see citing works
Volitional social interaction prevents drug addiction in rat models
Venniro, M., Zhang, M., Caprioli, D., Hoots, J. K., Golden, S. A., Heins, C., Morales, M., Epstein, D. H., & Shaham, Y. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0246-6 · Cited by 342 · see citing works
Natural rewards, neuroplasticity, and non-drug addictions
Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339 · see citing works
Self‐administration of drugs in animals and humans as a model and an investigative tool
Panlilio, L. V., & Goldberg, S. R. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02011.x · Cited by 322 · see citing works
Everitt, B. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12644 · Cited by 318 · see citing works
Time to connect: bringing social context into addiction neuroscience
Heilig, M., Epstein, D. H., Nader, M. A., & Shaham, Y. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.67 · Cited by 298 · see citing works
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“…have been developed to model compulsive drug seeking despite negative consequences, which pair drug delivery with various aversive stimuli such as electric shock (Deroche-Gamonet et al. 2004), bitter taste (Wolffgramm and Heyne 1995), or fear-conditioned cues (Vanderschuren and Everitt 2004).”
Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300 · see citing works
Boileau, I., Dagher, A., Leyton, M., Gunn, R. N., Baker, G. B., Diksic, M., & Benkelfat, C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1386 · Cited by 305 · see citing works
Ferrario, C. R., Gorny, G., Crombag, H. S., Li, Y., Kolb, B., & Robinson, T. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.046 · Cited by 283 · see citing works
Hogarth, L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0600-8 · Cited by 281 · see citing works
The persistence of maladaptive memory: Addiction, drug memories and anti-relapse treatments
Milton, A. L., & Everitt, B. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.01.002 · Cited by 279 · see citing works
Chaudhri, N., Caggiula, A. R., Donny, E. C., Palmatier, M. I., Liu, X., & Sved, A. F. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0178-1 · Cited by 271 · see citing works
AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
Wolf, M. E., & Ferrario, C. R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.013 · Cited by 271 · see citing works
A molecular mechanism for choosing alcohol over an alternative reward
Augier, E., Barbier, E., Dulman, R. S., Licheri, V., Augier, G., Domi, E., Barchiesi, R., Farris, S., Nätt, D., Mayfield, R. D., et al. (2018) · Science · doi:10.1126/science.aao1157 · Cited by 241 · see citing works
Calculating utility: preclinical evidence for cost–benefit analysis by mesolimbic dopamine
Phillips, P. E. M., Walton, M. E., & Jhou, T. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0626-6 · Cited by 237 · see citing works
Hogarth, L., & Chase, H. W. (2011) · Journal of Experimental Psychology: Animal Behavior Processes · doi:10.1037/a0022913 · Cited by 225 · see citing works
A multistep general theory of transition to addiction
Piazza, P. V., & Deroche-Gamonet, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3224-4 · Cited by 227 · see citing works
Self-citationImproving translation of animal models of addiction and relapse by reverse translation
Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H., & Shaham, Y. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0378-z · Cited by 212 · see citing works
Multiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works
Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models
Schramm-Sapyta, N. L., Walker, Q. D., Caster, J. M., Levin, E. D., & Kuhn, C. M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1585-5 · Cited by 215 · see citing works
Hasin, D., Hatzenbuehler, M. L., Keyes, K., & Ogburn, E. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01584.x · Cited by 213 · see citing works
Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis
Burke, A. R., & Miczek, K. A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3369-1 · Cited by 207 · see citing works
Stochastic synaptic plasticity underlying compulsion in a model of addiction
Pascoli, V., Hiver, A., Van Zessen, R., Loureiro, M., Achargui, R., Harada, M., Flakowski, J., & Lüscher, C. (2018) · Nature · doi:10.1038/s41586-018-0789-4 · Cited by 185 · see citing works
Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse
Willuhn, I., Wanat, M. J., Clark, J. J., & Phillips, P. E. M. (2010) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2009_27 · Cited by 193 · see citing works
How fast and how often: The pharmacokinetics of drug use are decisive in addiction
Allain, F., Minogianis, E.-A., Roberts, D. C. S., & Samaha, A.-N. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.012 · Cited by 192 · see citing works
Symposium overview–food addiction: fact or fiction?
Corwin, R. L., & Grigson, P. S. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.097691 · Cited by 175 · see citing works
Development of pharmacotherapies for drug addiction: a Rosetta stone approach
Koob, G. F., Kenneth Lloyd, G., & Mason, B. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2828 · Cited by 154 · see citing works
On habits and addiction: an associative analysis of compulsive drug seeking
Ostlund, S. B., & Balleine, B. W. (2008) · Drug Discovery Today: Disease Models · doi:10.1016/j.ddmod.2009.07.004 · Cited by 147 · see citing works
Caprioli, D., Venniro, M., Zeric, T., Li, X., Adhikary, S., Madangopal, R., Marchant, N. J., Lucantonio, F., Schoenbaum, G., Bossert, J. M., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.018 · Cited by 145 · see citing works
Neuroimaging for drug addiction and related behaviors
Parvaz, M. A., Alia-Klein, N., Woicik, P. A., Volkow, N. D., & Goldstein, R. Z. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.055 · Cited by 151 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Carson, D. S., Cornish, J. L., Guastella, A. J., Hunt, G. E., & McGregor, I. S. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.018 · Cited by 146 · see citing works
Berrendero, F., Robledo, P., Trigo, J. M., Martín-García, E., & Maldonado, R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.006 · Cited by 140 · see citing works
Pathological overeating: emerging evidence for a compulsivity construct
Moore, C. F., Sabino, V., Koob, G. F., & Cottone, P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.269 · Cited by 126 · see citing works
Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats
Venniro, M., Russell, T. I., Zhang, M., & Shaham, Y. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.018 · Cited by 127 · see citing works
The HR/LR model: further evidence as an animal model of sensation seeking
Blanchard, M. M., Mendelsohn, D., & Stamp, J. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.009 · Cited by 121 · see citing works
Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction
Pierce, R. C., & Vanderschuren, L. J. M. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.007 · Cited by 115 · see citing works
Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking
Jonkman, S., Pelloux, Y., & Everitt, B. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0348-12.2012 · Cited by 107 · see citing works
Vazquez, V., Penit-Soria, J., Durand, C., Besson, M. J., Giros, B., & Daugé, V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4807-04.2005 · Cited by 101 · see citing works
Jadhav, K. S., Peterson, V. L., Halfon, O., Ahern, G., Fouhy, F., Stanton, C., Dinan, T. G., Cryan, J. F., & Boutrel, B. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.026 · Cited by 101 · see citing works
Dual action of ketamine confines addiction liability
Simmler, L. D., Li, Y., Hadjas, L. C., Hiver, A., van Zessen, R., & Lüscher, C. (2022) · Nature · doi:10.1038/s41586-022-04993-7 · Cited by 95 · see citing works
Porter, J. N., Olsen, A. S., Gurnsey, K., Dugan, B. P., Jedema, H. P., & Bradberry, C. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5426-10.2011 · Cited by 97 · see citing works
Harvey, R. C., Sen, S., Deaciuc, A., Dwoskin, L. P., & Kantak, K. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.223 · Cited by 86 · see citing works
Adriani, W., Deroche-Gamonet, V., Le Moal, M., Laviola, G., & Piazza, P. V. V. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0125-1 · Cited by 86 · see citing works
Self-citationBesson, M., Pelloux, Y., Dilleen, R., Theobald, D. E., Lyon, A., Belin-Rauscent, A., Robbins, T. W., Dalley, J. W., Everitt, B. J., & Belin, D. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.95 · Cited by 81 · see citing works
Dopamine Circuit Mechanisms of Addiction-Like Behaviors
Poisson, C. L., Engel, L., & Saunders, B. T. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.752420 · Cited by 75 · see citing works
Ferrario, C. R., & Robinson, T. E. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.08.005 · Cited by 65 · see citing works
Kallupi, M., Carrette, L. L. G., Kononoff, J., Solberg Woods, L. C., Palmer, A. A., Schweitzer, P., George, O., & de Guglielmo, G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915143117 · Cited by 64 · see citing works
Addiction, cognitive decline and therapy: Seeking ways to escape a vicious cycle
Perry, C. J., & Lawrence, A. J. (2017) · Genes, Brain and Behavior · doi:10.1111/gbb.12325 · Cited by 60 · see citing works
Jordi, E., Heiman, M., Marion-Poll, L., Guermonprez, P., Cheng, S. K., Nairn, A. C., Greengard, P., & Girault, J.-A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307116110 · Cited by 57 · see citing works
Incubation of depression: ECM assembly and parvalbumin interneurons after stress
Spijker, S., Koskinen, M.-K., & Riga, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.015 · Cited by 55 · see citing works
Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers
Casey, K. F., Benkelfat, C., Young, S. N., & Leyton, M. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.02.002 · Cited by 54 · see citing works
Laque, A., L. De Ness, G., Wagner, G. E., Nedelescu, H., Carroll, A., Watry, D., M. Kerr, T., Koya, E., Hope, B. T., Weiss, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11799-1 · Cited by 43 · see citing works
Wei, N.-L., Quan, Z.-F., Zhao, T., Yu, X.-D., Xie, Q., Zeng, J., Ma, F.-K., Wang, F., Tang, Q.-S., Wu, H., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s204818 · Cited by 46 · see citing works
Amphetamine reward in the monogamous prairie vole
Aragona, B. J., Detwiler, J. M., & Wang, Z. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.019 · Cited by 45 · see citing works
Enhanced methamphetamine self-administration in a neurodevelopmental rat model of schizophrenia
Brady, A. M., McCallum, S. E., Glick, S. D., & O’Donnell, P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1195-7 · Cited by 43 · see citing works
Kelamangalath, L., & Wagner, J. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.006 · Cited by 25 · see citing works
N. Kearns, D., A. Gomez-Serrano, M., & J. Tunstall, B. (2011) · Current Drug Abuse Reviewse · doi:10.2174/1874473711104040261 · Cited by 22 · see citing works
Cadoni, C., De Felice, M., Corongiu, S., Dessì, C., Espa, E., Melis, M., & Fenu, S. (2020) · Addiction Biology · doi:10.1111/adb.12803 · Cited by 10 · see citing works
- Authors
- Deroche-Gamonet, V., Belin, D., & Piazza, P. V.
- Affiliations
- INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux Institute for Neurosciences, University Victor Segalen–Bordeaux 2, Domaine de Carreire, Rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France.
- Inserm (FR)
- Corresponding author
- Piazza, Pier Vincenzo
- Venue
- Science
- Published
- 2004-08-13
- Volume
- 305
- Issue
- 5686
- Pages
- 1014-1017
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2112323466
- Cited by
- 1,135
- References
- 29
- Citations by year
- 2026: 23 · 2025: 36 · 2024: 34 · 2023: 42 · 2022: 52 · 2021: 63 · 2020: 65 · 2019: 60 · 2018: 58 · 2017: 60 · 2016: 60 · 2015: 51 · 2014: 73 · 2013: 78 · 2012: 65
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- addiction-like behavior, cocaine self-administration, animal models of addiction, drug addiction, rats
- MeSH terms
- Animals, Cocaine, Cues, Electroshock, Humans, Male, Motivation, Motor Activity, Reward, Self Administration, Time Factors, Behavior, Addictive, Rats, Sprague-Dawley, Cocaine-Related Disorders, Models, Animal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review