Cited by 1,135Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Evidence for Addiction-like Behavior in the Rat

Deroche-Gamonet, Véronique, Belin, David, Piazza, Pier Vincenzo·2004·Science

Abstract

Although the voluntary intake of drugs of abuse is a behavior largely preserved throughout phylogeny, it is currently unclear whether pathological drug use (“addiction”) can be observed in species other than humans. Here, we report that behaviors that resemble three of the essential diagnostic criteria for addiction appear over time in rats trained to self-administer cocaine. As in humans, this addiction-like behavior is present only in a small proportion of subjects using cocaine and is highly predictive of relapse after withdrawal. These findings provide a new basis for developing a true understanding and treatment of addiction.

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Crossref · 10.1126/science.1099020

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29 of 29 references verified0 citation errors · 0 not checkable

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  • Paradigms have been developed to model compulsive drug-seeking despite negative consequences by pairing drug delivery with aversive stimuli.

    “More recently, paradigms have been developed to model compulsive drug-seeking despite negative consequences, which pair drug delivery with various aversive stimuli such as electric shock (Deroche-Gamonet et al 2004), bitter taste (Wolffgramm and Heyne 1995), or fear-conditioned cues (Vanderschuren and Everitt 2004).”

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Authors
Deroche-Gamonet, V., Belin, D., & Piazza, P. V.
Affiliations
  • INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux Institute for Neurosciences, University Victor Segalen–Bordeaux 2, Domaine de Carreire, Rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France.
  • Inserm (FR)
Corresponding author
Piazza, Pier Vincenzo
Venue
Science
Published
2004-08-13
Volume
305
Issue
5686
Pages
1014-1017
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2112323466
Cited by
1,135
References
29
Citations by year
2026: 23 · 2025: 36 · 2024: 34 · 2023: 42 · 2022: 52 · 2021: 63 · 2020: 65 · 2019: 60 · 2018: 58 · 2017: 60 · 2016: 60 · 2015: 51 · 2014: 73 · 2013: 78 · 2012: 65
FWCI
14.79
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
addiction-like behavior, cocaine self-administration, animal models of addiction, drug addiction, rats
MeSH terms
Animals, Cocaine, Cues, Electroshock, Humans, Male, Motivation, Motor Activity, Reward, Self Administration, Time Factors, Behavior, Addictive, Rats, Sprague-Dawley, Cocaine-Related Disorders, Models, Animal, Rats

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