Deep brain stimulation for obsessive-compulsive disorder: why anatomy matters
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For VC/VS DBS, a complex combination of internal capsule fibers to the ventrolateral and medial prefrontal cortex is consistently associated with response in DBS for OCD.
“For VC/VS DBS, a complex combination of internal capsule fibers to the ventrolateral and medial prefrontal cortex is consistently associated to response in DBS for OCD [89]”
From Deep brain stimulation for depression. (2022) · cites this paper as [89]
Cites
Nuttin, B., Cosyns, P. R., Demeulemeester, H. G., Gybels, J., & Meyerson, B. A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02376-4 · Cited by 854 · see citing works
Denys, D., Mantione, M., Figee, M., van den Munckhof, P., Koerselman, F., Westenberg, H., Bosch, A., & Schuurman, R. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.122 · Cited by 763 · see citing works
Self-citationDeep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
Figee, M., Luigjes, J., Smolders, R., Valencia-Alfonso, C.-E., van Wingen, G., de Kwaasteniet, B., Mantione, M., Ooms, P., de Koning, P., Vulink, N., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3344 · Cited by 466 · see citing works
Self-citationRiva-Posse, P., Choi, K. S., Holtzheimer, P. E., Crowell, A. L., Garlow, S. J., Rajendra, J. K., McIntyre, C. C., Gross, R. E., & Mayberg, H. S. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.59 · Cited by 441 · see citing works
Self-citationA unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
Li, N., Baldermann, J. C., Kibleur, A., Treu, S., Akram, H., Elias, G. J. B., Boutet, A., Lozano, A. M., Al‐Fatly, B., Strange, B. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16734-3 · Cited by 317 · see citing works
Widge, A. S., Zorowitz, S., Basu, I., Paulk, A. C., Cash, S. S., Eskandar, E. N., Deckersbach, T., Miller, E. K., & Dougherty, D. D. (2019) · Nature Communications · doi:10.1038/s41467-019-09557-4 · Cited by 152 · see citing works
Four Deep Brain Stimulation Targets for Obsessive-Compulsive Disorder: Are They Different?
Haber, S. N., Yendiki, A., & Jbabdi, S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.031 · Cited by 134 · see citing works
Liebrand, L. C., Caan, M. W. A., Schuurman, P. R., van den Munckhof, P., Figee, M., Denys, D., & van Wingen, G. A. (2019) · Brain Stimulation · doi:10.1016/j.brs.2018.11.014 · Cited by 98 · see citing works
Self-citationDeep brain stimulation modulates directional limbic connectivity in obsessive-compulsive disorder
Fridgeirsson, E. A., Figee, M., Luigjes, J., van den Munckhof, P., Schuurman, P. R., van Wingen, G., & Denys, D. (2020) · Brain · doi:10.1093/brain/awaa100 · Cited by 51 · see citing works
Self-citationA Systematic Review of Deep Brain Stimulation Targets for Obsessive Compulsive Disorder
Raviv, N., Staudt, M. D., Rock, A., MacDonell, J., Slyer, J., & Pilitsis, J. G. (2020) · Neurosurgery · doi:10.1093/neuros/nyaa249 · Cited by 51 · see citing works
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Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works
Self-citationMapping electrophysiological connectivity of pulvinar in seizure propagation and neuromodulation
Yao, Y., Wang, X., Zhao, B., Hu, W., Wang, L., Shao, X., Guo, Z., Yang, B., Li, Z., Cai, D., et al. (2025) · Epilepsia · doi:10.1111/epi.18537 · Cited by 4 · see citing works
Lauro, P. M., Palmer, C. F., Nambiar, M. M., Muller, U., Qiu, L., Halpern, C. H., & Scangos, K. W. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1828620
Seilheimer, R. L., Vardalakis, N., Choi, W. B., Qiu, L., Campos, G., Nho, Y., Chen, H., Shuvaev, S., Noecker, A. M., Chang, A., et al. (2026) · medRxiv · doi:10.64898/2026.10.19.26365556
- Authors
- Figee, M., & Mayberg, H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Figee, Martijn
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 90
- Issue
- 10
- Pages
- 662-663
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W3206761409
- Cited by
- 4
- References
- 10
- Citations by year
- 2026: 2 · 2025: 1 · 2022: 1
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (1R01MH123542-01A1)
- National Institute of Neurological Disorders and Stroke (UH3NS103550)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, obsessive-compulsive disorder, treatment-resistant OCD, anterior limb of the internal capsule, ventral striatum, subthalamic nucleus, anterior cingulate cortex, limbic system, neuroanatomy
- MeSH terms
- Brain, Humans, Obsessive-Compulsive Disorder, Deep Brain Stimulation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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