The DOI matches its Crossref record.
Epitranscriptomic and Metabolomic Signatures Involved in Translational Mechanisms of Suicide and Depression
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Impaired cortical NSUN2 exerts bidirectional impacts on tRNA methylation and induces depression-like behavior in the mouse brain by altering the translational dynamics of Glycine-rich synaptic proteins.
“By altering the translational dynamics of Glycine (Gly)-rich synaptic proteins, the impaired cortical NSUN2, which is a tRNA methyltransferase, exerts bidirectional impacts on tRNA methylation and induces depression-like behavior in the mouse brain.371”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [371]
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
“371 Antidepressant treatments are associated with RNA modi fi cation Altered epigenetic modi fi cation of m 6 A mRNA may contribute to therapeutic responses in psychiatric disorders.”
BackgroundThe role of RNA-modifying proteins in renal cell carcinoma
Alhammadi, M. A., Bajbouj, K., Talaat, I. M., & Hamoudi, R. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06479-y · Cited by 9
“Epitranscrip-tomic modi fi cations were found to be involved in many diseases, including cancer [26], cardiovascular diseases [27], diabetes [28, 29], obesity [28, 30], and major depressive disorder [31].”
Selective detection of picolinic acid by molecularly imprinted polymer based electrochemical sensor
Zulkefli, N. A., Mehamod, F. S., Jani, A. M. M., Jusoh, N. H. S., & Suah, F. B. M. (2023) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/s43578-023-01136-0 · Cited by 1
“Studies have linked PIC to vascular cognitive impairment (VCI) [1], suicidal behavior [2], and its potential role during pregnancy [4].”
Background
Metadata
- Authors
- Blaze, J., Plaza-Jennings, A., Turecki, G., Haghighi, F., & Akbarian, S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- McGill University (CA)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 91
- Issue
- 9
- Pages
- S73-S74
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W4224982995
- Cited by
- 3
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- tRNA methylation, NSUN2, tRNA methyltransferase, translational regulation, major depressive disorder, suicide, postmortem brain, epitranscriptomics, depression
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