Caffeine effects on resting-state electrodermal levels in AD/HD suggest an anomalous arousal mechanism
Abstract
The effect of a single oral dose of caffeine was examined in a randomised double-blind placebo-controlled repeated-measures cross-over study. Eighteen children with AD/HD, aged between 8 and 13 years, were individually age- and gender-matched with a control group. All children participated in two sessions, one week apart. Skin conductance level (SCL) from a 3 min eyes-closed epoch, commencing 30 min after ingestion of caffeine or placebo, was examined. Across conditions, mean SCL was lower in the AD/HD group than controls, confirming hypoarousal in AD/HD. Caffeine produced an increase in SCL, and this increase did not differ between the groups. However, arousal increases were dose-dependent in controls, but not in AD/HD. Rather, caffeine-induced arousal increases in the AD/HD group were positively related to their hyperactivity/impulsivity levels. This suggests an anomalous arousal mechanism in AD/HD functionally related to impairment in one symptom dimension.
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In Barry et al. (2012), the caffeine-induced increase in SCL was dependent on dose in controls but not in ADHD.
“while in controls this increase was dependent on the dose, in ADHD it was not”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Barry et al., 2012
Since Barry et al. (2012) was the only study investigating caffeine, a clear conclusion cannot be fully supported.
“Since this was the only study investigating caffeine, a clear conclusion cannot be fully supported.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Barry et al., 2012
The Barry et al. (2012) result suggests reduced sensitivity to the dose of caffeine in ADHD.
“suggesting reduced sensitivity to the dose of caffeine, which is a natural stimulant, in ADHD.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Barry et al., 2012
Barry et al. (2012) found that in controls and children/adolescents with ADHD, caffeine increased SCL at rest.
“One other study focused on analysing the effects of caffeine (Barry et al., 2012) and found that in controls and children/adolescents with ADHD, caffeine increased SCL at rest.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Barry et al., 2012
In Barry et al. (2012), although ADHD and TD showed similar increase of SCL during resting-state, after caffeine administration, in ADHD this increase was not dependent on the dose, while in TD it was.
“Although ADHD and TD showed similar increase of SCL during resting-state, after caffeine administration, in ADHD this increase was not dependent on the dose, while in TD it was.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Barry et al., 2012
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- Authors
- Barry, R. J., Clarke, A. R., McCarthy, R., Selikowitz, M., MacDonald, B., & Dupuy, F. E.
- Affiliations
- University of Wollongong (AU)
- Corresponding author
- Barry, Robert J.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 89
- Issue
- 3
- Pages
- 606-608
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2165405430
- Cited by
- 30
- References
- 20
- Citations by year
- 2024: 2 · 2023: 2 · 2021: 1 · 2020: 4 · 2019: 10 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Funders
- Australian Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- caffeine, attention deficit hyperactivity disorder, skin conductance level, electrodermal activity, hypoarousal, hyperactivity/impulsivity, children
- MeSH terms
- Adolescent, Central Nervous System Stimulants, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Caffeine, Child, Dose-Response Relationship, Drug, Double-Blind Method, Female, Galvanic Skin Response, Humans, Male, Reaction Time, Rest, Case-Control Studies, Cross-Over Studies
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