Cited by 48Microbial Metabolic Engineering and BioproductionProbiotics and Fermented FoodsBiofuel production and bioconversion

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Feeding strategies for enhanced lactobionic acid production from whey by Pseudomonas taetrolens

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Alonso, Saúl, Rendueles, Manuel, Díaz, Mario·2013·Bioresource Technology

DOI 10.1016/j.biortech.2013.01.145

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Abstract

High-level production of lactobionic acid from whey by Pseudomonas taetrolens under fed-batch fermentation was achieved in this study. Different feeding strategies were evaluated according to the physiological status and fermentation performance of P. taetrolens. A lactobionic acid titer of 164 g/L was obtained under co-feeding conditions affording specific and volumetric productivities of 1.4 g/g h and 2.05 g/L h, respectively. Flow cytometry assessment revealed that P. taetrolens cells exhibited a robust physiological status, which makes them particularly well-suited for employing concentrated nutrient solutions to further prolong the growth and production phases. Such detailed knowledge of the physiological status has been revealed to be a key issue to further support the development of high-yield lactobionic acid production processes under feeding strategies. The present study has demonstrated the feasibility of P. taetrolens to achieve high-level bio-production of lactobionic acid from whey through fed-batch cultivation, suggesting its major potential for industrial-scale implementation.

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ORGAN PRESERVATION
Southard, J. H., & Belzer, F. O. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.235 · Cited by 403
Application of flow cytometry to industrial microbial bioprocesses
Díaz, M., Herrero, M., García, L. A., & Quirós, C. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.07.013 · Cited by 307
Self-citation
Polyhydroxyalkanoate production from whey by Pseudomonas hydrogenovora
Koller, M., Bona, R., Chiellini, E., Fernandes, E. G., Horvat, P., Kutschera, C., Hesse, P. J., & Braunegg, G. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.09.049 · Cited by 222
Production of Poly(3-Hydroxybutyrate) by Fed-Batch Culture of Recombinant Escherichia coli with a Highly Concentrated Whey Solution
Ahn, W. S., Park, S. J., & Lee, S. Y. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.8.3624-3627.2000 · Cited by 195
Clinical and cosmeceutical uses of hydroxyacids
Green, B. A., Yu, R. J., & Scott, E. J. V. (2009) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2009.06.023 · Cited by 177
Galactosylated chitosan as a synthetic extracellular matrix for hepatocytes attachment
Park, I., Yang, J., Jeong, H., Bom, H., Harada, I., Akaike, T., Kim, S., & Cho, C. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00108-x · Cited by 162
Enhanced PHB production and scale up studies using cheese whey in fed batch culture of Methylobacterium sp. ZP24
Nath, A., Dixit, M., Bandiya, A., Chavda, S., & Desai, A. J. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.10.017 · Cited by 154
Surface modification of magnetite nanoparticles using lactobionic acid and their interaction with hepatocytes
Selim, K. M. K., Ha, Y.-S., Kim, S.-J., Chang, Y., Kim, T., Lee, G. H., & Kang, I. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.014 · Cited by 154
Origin and analysis of microbial population heterogeneity in bioprocesses
Müller, S., Harms, H., & Bley, T. (2010) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.01.002 · Cited by 141
The Application of Multi-Parameter Flow Cytometry to Monitor Individual Microbial Cell Physiological State
Hewitt, C. J., & Nebe‐von‐Caron, G. (2004) · Advances in biochemical engineering, biotechnology · doi:10.1007/b93997 · Cited by 141

Show all 34 references

The biotechnological potential of whey
Ryan, M. P., & Walsh, G. (2016) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-016-9402-1 · Cited by 212
Bio-production of lactobionic acid: Current status, applications and future prospects
Alonso, S., Rendueles, M., & Dı́az, M. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.04.010 · Cited by 144
Self-citation
Microbial production of specialty organic acids from renewable and waste materials
Alonso, S., Rendueles, M., & Dı́az, M. (2014) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2014.904269 · Cited by 127
Self-citation
Whey-derived valuable products obtained by microbial fermentation
Pescuma, M., de Valdez, G. F., & Mozzi, F. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6766-z · Cited by 125
Cultivation modes for microbial oil production using oleaginous yeasts – A review
Karamerou, E. E., & Webb, C. (2019) · Biochemical Engineering Journal · doi:10.1016/j.bej.2019.107322 · Cited by 96
Efficient production of l-lactic acid using co-feeding strategy based on cane molasses/glucose carbon sources
Xu, K., & Xu, P. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.11.057 · Cited by 83
Acidic Organic Compounds in Beverage, Food, and Feed Production
Quitmann, H., Fan, R., & Czermak, P. (2013) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2013_262 · Cited by 81
Synthesis of Lactose-Derived Nutraceuticals from Dairy Waste Whey—a Review
Nath, A., Verasztó, B., Basak, S., Koris, A., Kovács, Z., & Vatai, G. (2016) · Food and Bioprocess Technology · doi:10.1007/s11947-015-1572-2 · Cited by 71
Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review
Krzyżostan, M., Wawrzyńczak, A., & Nowak, I. (2024) · Sustainability · doi:10.3390/su16072757 · Cited by 47
“In the non-edible parts of fruits (peels or twigs), the content of bioactive compounds, such as polyphenols, is often higher than in the edible parts (pulp) [65,73].”
Biotechnological Production of Organic Acids from Renewable Resources
Pleißner, D., Dietz, D., van Duuren, J. B. J. H., Wittmann, C., Yang, X., Lin, C. S. K., & Venus, J. (2017) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2016_73 · Cited by 49
The current status and future perspectives of lactobionic acid production : a review
Sarenkova, I., & Ciproviča, I. (2018) · Research for Rural Development/Research for Rural Development (Online) · doi:10.22616/rrd.24.2018.037 · Cited by 42
Simultaneous production of lactobionic and gluconic acid in cheese whey/glucose co-fermentation by Pseudomonas taetrolens
Alonso, S., Rendueles, M., & Dı́az, M. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.07.092 · Cited by 41
Self-citation
Challenges and prospects of yeast-based microbial oil production within a biorefinery concept
Gallego-García, M., Susmozas, A., Negro, M. J., & Moreno, A. D. (2023) · Microbial Cell Factories · doi:10.1186/s12934-023-02254-4 · Cited by 36
Enhancement of Lactobionic Acid Productivity by Homologous Expression of Quinoprotein Glucose Dehydrogenase in Pseudomonas taetrolens
Oh, Y., Jang, Y.-A., Lee, S. S., Kim, J., Hong, S. H., Han, J. J., & Eom, G. T. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04246 · Cited by 34
High-level production and high-yield recovery of lactobionic acid by the control of pH and temperature in fermentation of Pseudomonas taetrolens
Kim, J.-H., Jang, Y.-A., Seong, S.-B., Jang, S. A., Hong, S. H., Song, J. K., & Eom, G. T. (2020) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-020-02290-z · Cited by 32
Reprogramming Escherichia coli Metabolism for Bioplastics Synthesis from Waste Cooking Oil
Li, Y., Cheng, Z., Zhao, C., Gao, C., Song, W., Liu, L., & Chen, X. (2021) · ACS Synthetic Biology · doi:10.1021/acssynbio.1c00155 · Cited by 28
Cellobiose dehydrogenase-based biomedical applications
Nyanhongo, G. S., Thallinger, B., & Guebitz, G. M. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.02.023 · Cited by 27
Some instrumental methods applied in food chemistry to characterise lactulose and lactobionic acid
Bisinella, R. Z. B., Ribeiro, J. C. B., de Oliveira, C. S., Colman, T. A. D., Schnitzler, E., & Masson, M. L. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.10.018 · Cited by 25
Efficient production of sugar-derived aldonic acids by Pseudomonas fragi TCCC11892
Mao, S., Liu, Y., Hou, Y., Ma, X., Yang, J., Han, H., Wu, J., Jia, L., Qin, H., & Lu, F. (2018) · RSC Advances · doi:10.1039/c8ra07556e · Cited by 22
An integrated bio-process for production of functional biomolecules utilizing raw and by-products from dairy and sugarcane industries
Lata, K., Sharma, M., Patel, S., Sangwan, R., & Singh, S. P. (2018) · Bioprocess and biosystems engineering (Print) · doi:10.1007/s00449-018-1941-0 · Cited by 18
Tunable decoupled overproduction of lactobionic acid in Pseudomonas taetrolens through temperature-control strategies
Alonso, S., Rendueles, M., & Díaz, M. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.04.034 · Cited by 21
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Oh, Y., Jang, Y.-A., Hong, S. H., & Eom, G. T. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04094 · Cited by 20
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Mobayed, F. H., Nunes, J. C., Gennari, A., de Andrade, B. C., Ferreira, M. L. V., Pauli, P., Renard, G., Chies, J. M., Volpato, G., & de Souza, C. F. V. (2020) · Biotechnology Letters · doi:10.1007/s10529-020-03028-3 · Cited by 12
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Lin, S., Li, C.-Y., & Chung, Y. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12582 · Cited by 11
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You, S., Wang, X., Qi, W. D., Su, R., & He, Z. (2017) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13464 · Cited by 9
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Nagaraj, V., Upadhyay, N., Nath, B. S., & Singh, A. K. (2018) · InTech eBooks · doi:10.5772/intechopen.76312 · Cited by 9
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Khallouk, K., Solhy, A., Khalfaouy, R. E., Kherbeche, A., & Barakat, A. (2022) · Catalysis Letters · doi:10.1007/s10562-022-04151-8 · Cited by 5
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Otter, D. E., Wu, S., & Jayasinghe, D. N. D. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-92585-7_5 · Cited by 4
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Khurana, S., Kankarwal, P., Saini, J., Panghal, P., Panghal, A., & Chhikara, N. (2023) · Springer eBooks · doi:10.1007/978-981-99-5459-9_7 · Cited by 4
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Additional file 1 of Valorization of cheese whey to lactobionic acid by a novel strain Pseudomonas fragi and identification of enzyme involved in lactose oxidation
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Authors: Alonso, S., Rendueles, M., & Díaz, M.
Affiliations: Universidad de Oviedo (ES)
ORCID: Alonso, Saúl
Rendueles, Manuel
Venue: Bioresource Technology
Publisher: Elsevier BV
Published: 2013-04
Volume: 134
Pages: 134-142
ISSN: 0960-8524 (ISSN-L)
DOI: 10.1016/j.biortech.2013.01.145
OpenAlex: W2051962386
Cited by: 48
References: 34
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 3
FWCI: 1.64
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Bioresource Technology (publishedVersion)
PubMed (publishedVersion)
Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
Funders: Ministerio de Economía y Competitividad
Ministerio de Ciencia e Innovación
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Keywords: lactobionic acid, whey, Pseudomonas taetrolens, fed-batch fermentation, feeding strategies, co-feeding, fermentation physiology, flow cytometry, biotransformation, industrial fermentation
MeSH terms: Biotechnology, Dairy Products, Disaccharides, Hydrogen-Ion Concentration, Pseudomonas, Time Factors, Biomass, Bioreactors, Batch Cell Culture Techniques

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Feeding strategies for enhanced lactobionic acid production from whey by Pseudomonas taetrolens

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