CoChat
Sign Up
Cited by 195Biosensors and Analytical DetectionElectrochemical sensors and biosensorsSalivary Gland Disorders and Functions

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Hand-held monitor of sympathetic nervous system using salivary amylase activity and its validation by driver fatigue assessment

Yamaguchi, Masaki, Deguchi, Mitsuo, Wakasugi, Junichi, Ono, Shin, Takai, Noriyasu, Higashi, Tomoyuki, Mizuno, Yasufumi·2006·Biosensors and Bioelectronics
DOI 10.1016/j.bios.2005.03.014
Open this paper in CoChat — free account

Abstract

In order to realize a hand-held monitor of the sympathetic nervous system, we fabricated a completely automated analytical system for salivary amylase activity using a dry-chemistry system. This was made possible by the fabrication of a disposable test-strip equipped with built-in collecting and reagent papers and an automatic saliva transfer device. In order to cancel out the effects of variations in environmental temperature and pH of saliva, temperature- and pH-adjusted equations were experimentally determined, and each theoretical value was input into the memory of the hand-held monitor. Within a range of salivary amylase activity between 10 and 140 kU/l, the calibration curve for the hand-held monitor showed a coefficient with R(2)=0.97. Accordingly, it was demonstrated that the hand-held monitor enabled a user to automatically measure the salivary amylase activity with high accuracy with only 30 microl sample of saliva within a minute from collection to completion of the measurement. In order to make individual variations of salivary amylase activity negligible during driver fatigue assessment, a normalized equation was proposed. The normalized salivary amylase activity correlated with the mental and physical fatigue states. Thus, this study demonstrated that an excellent hand-held monitor with an algorithm for normalization of individuals' differences in salivary amylase activity, which could be easily and quickly used for evaluating the activity of the sympathetic nervous system at any time. Furthermore, it is suggested that the salivary amylase activity might be used as a better index for psychological research.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bios.2005.03.014

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 29 references

Research works printed but not linked: 2

  1. NC-IUBMB, 1992. Enzyme Nomenclature. Academic Press Inc., San Diego.
  2. Yamaguchi, 2001, Correlation of stress and salivary amylase activity, Jpn J. Med. Electron. Biol. Eng., 39, 234

Cited by

Sorted by citations

Items 101–194 of 194

Related

See all

Metadata

Authors
Yamaguchi, M., Deguchi, M., Wakasugi, J., Ono, S., Takai, N., Higashi, T., & Mizuno, Y.
Affiliations
  • University of Toyama (JP)
  • Osaka Dental University (JP)
  • Yamaha Motor Co., Ltd. (Japan) (JP)
Corresponding author
Yamaguchi, Masaki
ORCID
Yamaguchi, Masaki
Venue
Biosensors and Bioelectronics
Publisher
Elsevier BV
Published
2006-01
Volume
21
Issue
7
Pages
1007-1014
ISSN
0956-5663 (ISSN-L)
DOI
10.1016/j.bios.2005.03.014
OpenAlex
W2052099325
Cited by
195
References
29
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 17 · 2016: 11 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 18
FWCI
5.20
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biosensors and Bioelectronics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Nipro
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
  • Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
  • Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Keywords
salivary amylase activity, sympathetic nervous system, driver fatigue, disposable test strip, saliva collection devices, mental fatigue, physical fatigue
MeSH terms
Adult, Amylases, Automobile Driving, Enzyme Activation, Equipment Design, Fatigue, Female, Humans, Middle Aged, Miniaturization, Photometry, Reagent Kits, Diagnostic, Saliva, Sensitivity and Specificity, Specimen Handling, Sympathetic Nervous System, Reproducibility of Results, Biosensing Techniques, Biomarkers, Equipment Failure Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review